Detection of early cardiac effects through strain rate imaging in patients undergoing breast cancer treatment with trastuzumab
| العنوان: | Detection of early cardiac effects through strain rate imaging in patients undergoing breast cancer treatment with trastuzumab |
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| المؤلفون: | C. Gennatas, G. Koutroulis, V. Michalaki, Spyridon Gennatas |
| المصدر: | Journal of Clinical Oncology. 29:e11093-e11093 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Oncology, Cardiac function curve, Cancer Research, medicine.medical_specialty, Cardiotoxicity, Ejection fraction, business.industry, Early detection, medicine.disease, Breast cancer, Trastuzumab, Strain rate imaging, Internal medicine, Cardiology, Medicine, In patient, skin and connective tissue diseases, business, medicine.drug |
| الوصف: | e11093 Background:Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial dysfunction. Changes in cardiac function induced by this therapy, however, are subtle and difficult to quantitate by conventional imaging methods. Doppler myocardial imaging-based velocity, strain, and strain rate measurements have been shown to sensitively quantify abnormalities in cardiac function in other settings. The aim of this study was to determine if sensitive indices of left ventricular (LV) dysfunction, specifically strain rate imaging, would be useful for addressing the early detection of trastuzumab mediated cardiotoxicity. Methods:In a pilot study, we examined 12 women (age 59.8 +/- 3.6 years) with breast cancer receiving 18 cycles of trastuzumab. Conventional and Doppler myocardial imaging echocardiography were obtained at baseline and every 3 months of ... |
| تدمد: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2011.29.15_suppl.e11093 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::d888925a87944acfc989488a19f15c21 https://doi.org/10.1200/jco.2011.29.15_suppl.e11093 |
| رقم الانضمام: | edsair.doi...........d888925a87944acfc989488a19f15c21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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| DOI: | 10.1200/jco.2011.29.15_suppl.e11093 |