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AB1041 PREVALENCE OF JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUBGROUPS AND JIA-ASSOCIATED UVEITIS AMONG JIA PATIENTS ADMITTED TO REFERRAL PEDIATRIC RHEUMATOLOGY CLINICS IN TURKEY: A RETROSPECTIVE STUDY, JUPITER

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العنوان: AB1041 PREVALENCE OF JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUBGROUPS AND JIA-ASSOCIATED UVEITIS AMONG JIA PATIENTS ADMITTED TO REFERRAL PEDIATRIC RHEUMATOLOGY CLINICS IN TURKEY: A RETROSPECTIVE STUDY, JUPITER
المؤلفون: Seza Ozen, Erbil Unsal, Fatma Zehra Kilic, Betül Sözeri, Ozgur Kasapcopur, Hafize Emine Sönmez, Yelda Bilginer, Ceyhun Acari, Hatice Adiguzel Dundar, Erdal Sag, Kenan Barut, Selcan Demir, Amra Adrovic, Sezgin Sahin
المصدر: Abstracts Accepted for Publication.
بيانات النشر: BMJ Publishing Group Ltd and European League Against Rheumatism, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Oligoarthritis, Childhood arthritis, business.industry, Arthritis, Retrospective cohort study, medicine.disease, Psoriatic arthritis, Cohort, medicine, Polyarthritis, Medical history, business
الوصف: Background Juvenile Idiopathic Arthritis (JIA) is a chronic childhood arthritis with onset before age of 16 and has a significant degree of morbidity that negatively affects quality of life. Uveitis, which is defined as the inflammation of the iris, ciliary body and choroid, is the most common cause of morbidity of JIA. This study was planned to collect data from a Turkish cohort to provide the initial national prevalence data of patients with JIA. Objectives The objective of this study was to determine the frequency of JIA subtypes in Turkey. We also aimed to assess the frequency and characteristics of eye involvement in JIA. Methods This national, non-interventional, multicenter, observational study was conducted in a retrospective manner in four study centers which were main referral pediatric rheumatology clinics across Turkey. Data on patient demography, medical history, JIA disease characteristics, laboratory data, cases of JIA-associated uveitis, JIA treatment history and data on other comorbidities were collected from a cohort of 500 patients. Results Oligoarthritis (n=194, 38.8%) was the most common JIA disease characteristic in this study cohort. The frequency of the subgroups was as follows: Enthesitis-Related Arthritis (ERA) in 23.2% (n=116), polyarthritis in 15.6% (n=78), systemic arthritis in 12.2% (n=61), psoriatic arthritis in 5.2% (n=26), idiopathic arthritis in 2.8% (n=14) and polyarthritis (RF+) in 2.2% (n=11) of patients were identified. The most frequently prescribed treatment for JIA was methotrexate (n=384, 76.8%). A total of 85 comorbidities were reported, and the most frequently reported comorbidity was Familial Mediterranean Fever (FMF) (n=63, 12.6%). The number of patients with JIA-associated uveitis diagnosis was 34 (6.8%), and the mean duration of uveitis was 3.2 (±2.3) years. The mean duration between the initial JIA diagnosis and diagnosis of uveitis was 1.8 (±1.9) years. Among 34 patients with uveitis, 45 eye involvements were identified; left eye, right eye and both eyes were affected in 5, 8 and 16 patients, respectively. Five patients (14.7%) had uveitis-related complications that required surgical intervention. Conclusion The main difference from the European Caucasian population is the lower frequency of oligoarticular JIA and higher frequency of ERA in Turkish JIA patients. Uveitis was also somewhat lower than expected. Geographic and ethnic factors, that may affect these differences, need further investigation. References [1] Barut K, Adrovic A, Sahin S and KasapCopur o. Juvenile Idiopathic Arthritis. Balkan Med J. 2017;34:90-101. [2] Demirkaya E, Ozen S, Bilginer Y, et al. The distribution of juvenile idiopathic arthritis in the eastern Mediterranean: results from the registry of the Turkish Paediatric Rheumatology Association. Clin Exp Rheumatol. 2011;29:111-6 Acknowledgement This JUPITER study is a collaborative study. Disclosure of Interests Sezgin Sahin: None declared, Ceyhun Acari: None declared, Hafize Emine Sonmez: None declared, Fatma Zehra Kilic: None declared, Erdal Sag: None declared, Hatice Adiguzel Dundar: None declared, Amra Adrovic: None declared, Selcan Demir: None declared, Kenan Barut: None declared, Yelda Bilginer: None declared, Betul Sozeri: None declared, Erbil Unsal Grant/research support from: Novartis, AbbVie, Roche, KoCak Pharma, Speakers bureau: Novartis, AbbVie, Roche, KoCak Pharma, Seza ozen Consultant for: Seza Ozen is receiving consultancy fees from Novartis, Speakers bureau: Roche, Ozgur Kasapcopur: None declared
DOI: 10.1136/annrheumdis-2019-eular.3138
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::999622662b7a46cf0a287f09ef5d9966
https://doi.org/10.1136/annrheumdis-2019-eular.3138
Rights: OPEN
رقم الانضمام: edsair.doi...........999622662b7a46cf0a287f09ef5d9966
قاعدة البيانات: OpenAIRE
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