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Hepatoprotective Effects of Selenium-Enriched Probiotics Supplementation on Heat-Stressed Wistar Rat Through Anti-Inflammatory and Antioxidant Effects

التفاصيل البيبلوغرافية
العنوان: Hepatoprotective Effects of Selenium-Enriched Probiotics Supplementation on Heat-Stressed Wistar Rat Through Anti-Inflammatory and Antioxidant Effects
المؤلفون: Maazullah Nasim, Kehe Huang, Rawan Ahmad Farid, Hu Li, Ilyas Ali, Xingxiang Chen, Rahmani Mohammad Malyar, Sayed Attaul Haq Banuree, Emal Naseri, Dandan Liu, Kevin J. Waldron, Khushdil Maroof
المصدر: Biological Trace Element Research.
بيانات النشر: Springer Science and Business Media LLC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: GPX1, medicine.medical_specialty, Antioxidant, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, SOD1, Inflammation, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Biochemistry, Anti-inflammatory, Inorganic Chemistry, 03 medical and health sciences, Internal medicine, medicine, 0105 earth and related environmental sciences, 0303 health sciences, Chemistry, 030302 biochemistry & molecular biology, Biochemistry (medical), General Medicine, Hsp70, Endocrinology, Apoptosis, medicine.symptom, Oxidative stress
الوصف: The purpose of this study was to elucidate the effects of selenium-enriched probiotics on the liver of heat-stressed Wistar rats. Ten-week-old male rats were assigned to four groups: control (Con); high temperature (HT); high temperature plus probiotics (HT + P: 1011 CFU/mL Lactobacillus acidophilus and 109 CFU/mL Saccharomyces cerevisiae); or high temperature plus selenium-enriched probiotics (HT + SeP: 0.3 mg/kg Se, 1011 CFU/mL L. acidophilus and 109 CFU/mL S. cerevisiae). The HT, HT + P, and HT + SeP groups were maintained at higher ambient temperature (40–42 °C), while the control group was kept at room temperature (25 °C). After 42 days of thermal exposure, blood and liver tissues were collected and analyzed for morphological and molecular markers of liver physiology. The body weight of rats in the HT group decreased but liver weight and live index were increased. Histological examination showed dilation of liver sinusoids and congestion of interstitial veins in HT group. Moreover, the histomorphology of the liver in HT + P and HT + SeP groups was restored, and the serum AST, ALT, ALP, LDH, and hepatic MDA level decreased significantly, but the serum total protein level and the liver SOD, T-AOC, and GSH-PX activities were increased significantly relative to the HT group. In addition, the mRNA level of Gpx1, SOD1, Nrf2, and Bcl-2 was significantly increased, while the expression level of Bax, IL-6, TNF-α, COX-2, NF-κB, α-SMA, TGFβ1, Collagen I, HSP70, and HSP90 was significantly decreased in liver tissues after SeP supplementation. We concluded that SeP can protect Wistar rats from oxidative stress, inflammation, apoptosis, and liver fibrosis induced by heat stress.
تدمد: 1559-0720
0163-4984
DOI: 10.1007/s12011-020-02475-3
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::996344f88ebae1a4f06679f1a69e9156
https://doi.org/10.1007/s12011-020-02475-3
Rights: OPEN
رقم الانضمام: edsair.doi...........996344f88ebae1a4f06679f1a69e9156
قاعدة البيانات: OpenAIRE
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