Effects of Japanese herbal medicine ?Sho-saiko-to? on in vitro production of tumor necrosis factor-alpha on peripheral blood mononuclear cells
| العنوان: | Effects of Japanese herbal medicine ?Sho-saiko-to? on in vitro production of tumor necrosis factor-alpha on peripheral blood mononuclear cells |
|---|---|
| المؤلفون: | Masayoshi Yamashiki, Qiao-Xi Zheng, Yoshitane Kosaka, Takeshi Nakano, Akira Nishimura, Tetsuro Sato, Hiroyuki Suzuki, Stephen P. James, Minoru Nomoto, Jan-Michael A. Klapproth |
| المصدر: | Drug Development Research. 31:170-174 |
| بيانات النشر: | Wiley, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Drug, Sho-saiko-to, business.industry, media_common.quotation_subject, Monocyte, medicine.medical_treatment, Pharmacognosy, medicine.disease, Peripheral blood mononuclear cell, medicine.anatomical_structure, Cytokine, Drug Discovery, Immunology, medicine, Tumor necrosis factor alpha, Liver cancer, business, media_common |
| الوصف: | “Xiao-Chai-Hu-Tang” is a herbal medicine that has been used for the treatment of pyretic diseases in China for several thousand years. In Japan, this medicine was modified into “Sho-saiko-to,” a prescription drug with standard quality and volume of ingredients. It is widely used as a biological response modifier in the treatment of chronic viral liver diseases. Several researchers have reported improvement of general physical conditions and the drug's usefulness in preventing liver cancer development. In this in vitro study, peripheral blood mononuclear cells (PBMC) were obtained from 12 healthy volunteers, and Sho-saiko-to (TJ-9) was added to the cultures of the PBMC. Dose-dependent increases in the levels of tumor necrosis factor-α (TNF-α) were observed in the cultures. Similar but smaller increases in the TNF-α levels were also observed when other Japanese herbal medicines, Dai-saiko-to (TJ-8) or Saiko-keishi-to (TJ-10), were added to the cultures. These results demonstrated that the increases of TNF-α levels are specifically due to Sho-saiko-to and other drugs with similar ingredients. TNF-α is believed to have anti-tumor effects and also to have an important role as IL-1 in the defense mechanism of the body. Therefore, the induction of TNF-α could also be useful in clinical treatment, and this effect could be one of the mechanisms by which Sho-saiko-to demonstrates efficacy in the treatment of patients with chronic viral liver diseases. © 1994 Wiley-Liss, Inc. |
| تدمد: | 1098-2299 0272-4391 |
| DOI: | 10.1002/ddr.430310304 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::92031144e1b430ff50f073d7ae6352d8 https://doi.org/10.1002/ddr.430310304 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........92031144e1b430ff50f073d7ae6352d8 |
| قاعدة البيانات: | OpenAIRE |
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