Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders
| العنوان: | Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders |
|---|---|
| المؤلفون: | Manijeh Khalili, Mostafa Bazi, Iraj Shahramian, Mojtaba Delaramnasab, Alireza Dechal, Masoud Jahantigh, Alireza Sargazi, Ali Bazi |
| المصدر: | Gene, Cell and Tissue. 7 |
| بيانات النشر: | Briefland, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Hepatitis, medicine.medical_specialty, Cirrhosis, medicine.diagnostic_test, business.industry, Liver fibrosis, medicine.disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, 030220 oncology & carcinogenesis, Internal medicine, Biopsy, medicine, Etiology, 030211 gastroenterology & hepatology, Stage (cooking), Hepatic fibrosis, business |
| الوصف: | Background: The applicability of non-invasive markers for predicting hepatic fibrosis in the pediatric population with chronic liver abnormalities is unclear. Objectives: We investigated the applicability of common non-invasive liver fibrosis parameters for detecting liver fibrosis in children with chronic hepatitis. Methods: This was a double-center study in Amir-Almomenin Hospital of Zabol and Namazi Hospital of Shiraz (2015 - 2017). Liver fibrosis was confirmed by biopsy examination. AST to platelet ratio (APRI), AST to ALT ratio (AAR), and Fibrosis-4 (FIB-4) were evaluated. Results: Out of 47 patients, 23 (48.9%) were females, and 24 (51.1%) were males. The mean age was 9.8 ± 11.3 months. APRI and FIB-4 correlated with fibrosis stages (r = 0.1 and r = 0.2, respectively). APRI showed an AUC of 0.541 for detecting non-advanced fibrosis (stages 0, 1, and 2). AAR and FIB-4 represented AUCs of 0.622 and 0.592 for advanced fibrosis and cirrhosis, respectively. The highest sensitivity of APRI (70%) was obtained at the cut-off point of 0.81 for cirrhosis. The highest specificities for APRI were observed at 0.66 (68%) and 1.37 (68%) for fibrotic stages 0 and 2, respectively. At the thresholds of 0.71 and 0.59, AAR rendered 78% sensitivity and 90% specificity for advanced fibrosis (stages 3 and 4) and no fibrosis (stage = 0), respectively. FIB-4 showed the highest sensitivity and specificity (70% and 60%) at the cut-off point of 0.21 for detecting cirrhosis. Conclusions: APRI, FIB-4, and AAR can be regarded as useful markers in predicting fibrotic transformation in children with various etiologies of chronic hepatitis. |
| تدمد: | 2345-6841 2345-6833 |
| DOI: | 10.5812/gct.101443 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7bc6f200f6212b285dd3f6da7ed071c0 https://doi.org/10.5812/gct.101443 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi...........7bc6f200f6212b285dd3f6da7ed071c0 |
| قاعدة البيانات: | OpenAIRE |
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