Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07
| العنوان: | Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07 |
|---|---|
| المؤلفون: | Bouke G. Hepkema, Shigeyuki Yokoyama, Seisuke Kusano, Laura Bungener, Hiroko Miyadera, Katsushi Tokunaga |
| المصدر: | Tissue Antigens. 86:413-418 |
| بيانات النشر: | Wiley, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | musculoskeletal diseases, Genetics, education.field_of_study, endocrine system diseases, Immunology, Haplotype, Population, nutritional and metabolic diseases, General Medicine, Human leukocyte antigen, Biology, Biochemistry, Null allele, Molecular biology, Phenotype, immune system diseases, Complementary DNA, HLA-DQ, Immunology and Allergy, Allele, skin and connective tissue diseases, education |
| الوصف: | Human leukocyte antigens (HLA)-DQA1*01:07 was identified as an HLA-DQ blank specificity that segregated with the serological HLA-A2, -B7, -DR14, -DR52 haplotype, which carried DQB1*05:03. The blank specificity of DQA1*01:07-DQB1*05:03 may be because of lack of reactivity of available typing sera, or disruption of proper assembly of DQ heterodimer. The cDNA sequence of DQA1*01:07 is nearly identical to DQA1*01:04 except for a variant at position 304, which results in the replacement of an arginine with a cysteine at 79α. To determine whether the DQA1*01:07 product can be expressed on cell-surface, we co-expressed DQA1*01:07 with various DQB1*05 or *06 alleles in fibroblast cells. Cell-surface expression of DQ was detectable when DQA1*01:07 was co-expressed with DQB1*06:04 but undetectable with other DQB1*05 and DQB1*06 alleles, including DQB1*05:03, to which DQA1*01:07 was encoded in cis. These data suggest that DQA1*01:07 may act as a phenotypically null allele in the DQA1*01:07-DQB1*05:03 haplotype, while it can be expressed at a low level in the presences of certain DQB1*06 alleles, such as DQB1*06:04, in trans. Based on the null or low expression of DQA1*01:07 as shown in the previous and present studies, DQA1*01:07 has recently been renamed to DQA1*01:07Q, indicating its questionable expression. |
| تدمد: | 0001-2815 |
| DOI: | 10.1111/tan.12686 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::00d5d7028828ebf7ccea88e99790870f https://doi.org/10.1111/tan.12686 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi...........00d5d7028828ebf7ccea88e99790870f |
| قاعدة البيانات: | OpenAIRE |
| ResultId |
1 |
|---|---|
| Header |
edsair OpenAIRE edsair.doi...........00d5d7028828ebf7ccea88e99790870f 814 3 unknown 814.281555175781 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsair&AN=edsair.doi...........00d5d7028828ebf7ccea88e99790870f&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://explore.openaire.eu/search/publication?articleId=doi_________::00d5d7028828ebf7ccea88e99790870f# [Name] => EDS - OpenAIRE [Category] => fullText [Text] => View record in OpenAIRE [MouseOverText] => View record in OpenAIRE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Bouke+G%2E+Hepkema%22">Bouke G. Hepkema</searchLink><br /><searchLink fieldCode="AR" term="%22Shigeyuki+Yokoyama%22">Shigeyuki Yokoyama</searchLink><br /><searchLink fieldCode="AR" term="%22Seisuke+Kusano%22">Seisuke Kusano</searchLink><br /><searchLink fieldCode="AR" term="%22Laura+Bungener%22">Laura Bungener</searchLink><br /><searchLink fieldCode="AR" term="%22Hiroko+Miyadera%22">Hiroko Miyadera</searchLink><br /><searchLink fieldCode="AR" term="%22Katsushi+Tokunaga%22">Katsushi Tokunaga</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>Tissue Antigens</i>. 86:413-418 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Wiley, 2015. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2015 ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22musculoskeletal+diseases%22">musculoskeletal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22education%2Efield%5Fof%5Fstudy%22">education.field_of_study</searchLink><br /><searchLink fieldCode="DE" term="%22endocrine+system+diseases%22">endocrine system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Haplotype%22">Haplotype</searchLink><br /><searchLink fieldCode="DE" term="%22Population%22">Population</searchLink><br /><searchLink fieldCode="DE" term="%22nutritional+and+metabolic+diseases%22">nutritional and metabolic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22General+Medicine%22">General Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Human+leukocyte+antigen%22">Human leukocyte antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Null+allele%22">Null allele</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+biology%22">Molecular biology</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotype%22">Phenotype</searchLink><br /><searchLink fieldCode="DE" term="%22immune+system+diseases%22">immune system diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Complementary+DNA%22">Complementary DNA</searchLink><br /><searchLink fieldCode="DE" term="%22HLA-DQ%22">HLA-DQ</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology+and+Allergy%22">Immunology and Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22Allele%22">Allele</searchLink><br /><searchLink fieldCode="DE" term="%22skin+and+connective+tissue+diseases%22">skin and connective tissue diseases</searchLink><br /><searchLink fieldCode="DE" term="%22education%22">education</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Human leukocyte antigens (HLA)-DQA1*01:07 was identified as an HLA-DQ blank specificity that segregated with the serological HLA-A2, -B7, -DR14, -DR52 haplotype, which carried DQB1*05:03. The blank specificity of DQA1*01:07-DQB1*05:03 may be because of lack of reactivity of available typing sera, or disruption of proper assembly of DQ heterodimer. The cDNA sequence of DQA1*01:07 is nearly identical to DQA1*01:04 except for a variant at position 304, which results in the replacement of an arginine with a cysteine at 79α. To determine whether the DQA1*01:07 product can be expressed on cell-surface, we co-expressed DQA1*01:07 with various DQB1*05 or *06 alleles in fibroblast cells. Cell-surface expression of DQ was detectable when DQA1*01:07 was co-expressed with DQB1*06:04 but undetectable with other DQB1*05 and DQB1*06 alleles, including DQB1*05:03, to which DQA1*01:07 was encoded in cis. These data suggest that DQA1*01:07 may act as a phenotypically null allele in the DQA1*01:07-DQB1*05:03 haplotype, while it can be expressed at a low level in the presences of certain DQB1*06 alleles, such as DQB1*06:04, in trans. Based on the null or low expression of DQA1*01:07 as shown in the previous and present studies, DQA1*01:07 has recently been renamed to DQA1*01:07Q, indicating its questionable expression. ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 0001-2815 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1111/tan.12686 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://explore.openaire.eu/search/publication?articleId=doi_________::00d5d7028828ebf7ccea88e99790870f" linkWindow="_blank">https://explore.openaire.eu/search/publication?articleId=doi_________::00d5d7028828ebf7ccea88e99790870f</link><br /><link linkTarget="URL" linkTerm="https://doi.org/10.1111/tan.12686" linkWindow="_blank">https://doi.org/10.1111/tan.12686</link> ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => CLOSED ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsair.doi...........00d5d7028828ebf7ccea88e99790870f ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1111/tan.12686
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => Undetermined
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 413
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => musculoskeletal diseases
[Type] => general
)
[1] => Array
(
[SubjectFull] => Genetics
[Type] => general
)
[2] => Array
(
[SubjectFull] => education.field_of_study
[Type] => general
)
[3] => Array
(
[SubjectFull] => endocrine system diseases
[Type] => general
)
[4] => Array
(
[SubjectFull] => Immunology
[Type] => general
)
[5] => Array
(
[SubjectFull] => Haplotype
[Type] => general
)
[6] => Array
(
[SubjectFull] => Population
[Type] => general
)
[7] => Array
(
[SubjectFull] => nutritional and metabolic diseases
[Type] => general
)
[8] => Array
(
[SubjectFull] => General Medicine
[Type] => general
)
[9] => Array
(
[SubjectFull] => Human leukocyte antigen
[Type] => general
)
[10] => Array
(
[SubjectFull] => Biology
[Type] => general
)
[11] => Array
(
[SubjectFull] => Biochemistry
[Type] => general
)
[12] => Array
(
[SubjectFull] => Null allele
[Type] => general
)
[13] => Array
(
[SubjectFull] => Molecular biology
[Type] => general
)
[14] => Array
(
[SubjectFull] => Phenotype
[Type] => general
)
[15] => Array
(
[SubjectFull] => immune system diseases
[Type] => general
)
[16] => Array
(
[SubjectFull] => Complementary DNA
[Type] => general
)
[17] => Array
(
[SubjectFull] => HLA-DQ
[Type] => general
)
[18] => Array
(
[SubjectFull] => Immunology and Allergy
[Type] => general
)
[19] => Array
(
[SubjectFull] => Allele
[Type] => general
)
[20] => Array
(
[SubjectFull] => skin and connective tissue diseases
[Type] => general
)
[21] => Array
(
[SubjectFull] => education
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Questionable expression of unstable DQ heterodimer containing HLA-DQA1*01:07
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bouke G. Hepkema
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Shigeyuki Yokoyama
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Seisuke Kusano
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Laura Bungener
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Hiroko Miyadera
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Katsushi Tokunaga
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 09
[M] => 11
[Type] => published
[Y] => 2015
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00012815
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsair
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 86
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Tissue Antigens
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |