Objective: To investigate whether glucagon like peptide-1 (GLP-1) can reduce the cholesterol in foam cells derived from macrophages by affecting the expression of CD36 and acyl- CoA1 (ACAT1) The content. Methods: Macrophages were obtained from mice, and after corresponding treatment, they were divided into 4 groups: blank control group, experimental group, GLP-1 agitation group, GLP-1 inhibition group, and the expression of CD36, ACAT1 mRNA and protein in cells of each group was detected. Expression and levels of total cholesterol (TC), free cholesterol (FC) and cholesterol ester (CE). Results: Compared with the blank control group, the content of TC, FC, CE and the expression of CD36, ACAT1 mRNA and protein in the experimental group were significantly increased (P