APOPTOSIS INDUCTION IN THE PHAGOCYTIC CELLS BY MYCOBACTERIUM TUBERCULOSISWITH DIFFERENT VIRULENCE
| العنوان: | APOPTOSIS INDUCTION IN THE PHAGOCYTIC CELLS BY MYCOBACTERIUM TUBERCULOSISWITH DIFFERENT VIRULENCE |
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| المؤلفون: | Zubriychuk OM, Ilyinskaya IF |
| المصدر: | Anali Mečnikìvsʹkogo Institutu, Vol 2, Pp 45-50 (2013) |
| بيانات النشر: | Mechnikov Institute of Microbiology and immunology, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | virulence, BCG vaccination, lcsh:R5-920, neutrophils, apoptosis, peritoneal macrophages, Mycobacterium tuberculosis, experimental tuberculosis, monocytes, lcsh:Medicine (General), vitality |
| الوصف: | The purpose of this study was to investigate the characteristics of phagocytic cells apoptosis induced in vitro and in vivo by Mycobacterium tuberculosis with different virulence. For this aim the main feachers of apoptosis of peritoneal macrophages, neutrophyles, monocytes, induced in vitro by living and dead MBT H37Rv and BCG in intact animals, healthy subjects and patients with tuberculosis were expected, as well as features of apoptosis of neutrophils and peritoneal macrophages of animals infected with MBT H37Rv and BCG. It was found that the virulent Mycobacterium tuberculosis have a powerful apoptogenic effect on phagocytic cells, and the loss of pathogen viability and virulence causes its weakening. It was demonstrated that the induction of apoptosis by Mycobacterium tuberculosis is realised both directly and indirectly, probably through their influence on the production of cell interaction mediators. It was detected that in order to limit excessive loss of phagocytes due to apoptosis, virulent mycobacteria use mechanisms that prevent infection of these cells. |
| اللغة: | English |
| تدمد: | 1993-4327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doajarticles::3507ff4db1e2c070a4e073c2ee04bf90 http://archive.nbuv.gov.ua/e-journals/AMI/2013_2/13iifoii.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doajarticles..3507ff4db1e2c070a4e073c2ee04bf90 |
| قاعدة البيانات: | OpenAIRE |
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