Periodical
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy
| العنوان: | The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy |
|---|---|
| المؤلفون: | Bornes, Laura, van Winden, Lennart J., Geurts, Veerle C. M., de Bruijn, Beaunelle, Azarang, Leyla, Lanfermeijer, Mirthe, Caruso, Marika, Proost, Natalie, Boeije, Manon, Lohuis, Jeroen O., Belthier, Guillaume, Noguera Delgado, Eulàlia, de Gruil, Nadia, Kroep, Judith R., van de Ven, Marieke, Menezes, Renee, Wesseling, Jelle, Kok, Marleen, Linn, Sabine, Broeks, Annegien, van Rossum, Huub H., Scheele, Colinda L. G. J., van Rheenen, Jacco |
| المصدر: | Nature; January 2025, Vol. 637 Issue: 8044 p195-204, 10p |
| مستخلص: | The response of breast cancer to neoadjuvant chemotherapy (NAC) varies substantially, even when tumours belong to the same molecular or histological subtype1. Here we identify the oestrous cycle as an important contributor to this heterogeneity. In three mouse models of breast cancer, we show reduced responses to NAC when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. Similar findings were observed in retrospective premenopausal cohorts of human patients. Mechanistically, the dioestrus stage exhibits systemic and localized changes, including (1) an increased number of cells undergoing epithelial-to-mesenchymal transition linked to chemoresistance2, 3–4and (2) decreased tumour vessel diameter, suggesting potential constraints to drug sensitivity and delivery. In addition, an elevated presence of macrophages, previously associated with chemoresistance induction5, characterizes the dioestrus phase. Whereas NAC disrupts the oestrous cycle, this elevated macrophage prevalence persists and depletion of macrophages mitigates the reduced therapy response observed when initiating treatment during dioestrus. Our data collectively demonstrate the oestrous cycle as a crucial infradian rhythm determining chemosensitivity, warranting future clinical studies to exploit optimal treatment initiation timing for enhanced chemotherapy outcomes. |
| قاعدة البيانات: | Supplemental Index |
| ResultId |
1 |
|---|---|
| Header |
edo Supplemental Index ejs68199110 1067 6 Periodical serialPeriodical 1067.11987304688 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edo&AN=ejs68199110&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
|
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Bornes%2C+Laura%22">Bornes, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22van+Winden%2C+Lennart+J%2E%22">van Winden, Lennart J.</searchLink><br /><searchLink fieldCode="AR" term="%22Geurts%2C+Veerle+C%2E+M%2E%22">Geurts, Veerle C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Bruijn%2C+Beaunelle%22">de Bruijn, Beaunelle</searchLink><br /><searchLink fieldCode="AR" term="%22Azarang%2C+Leyla%22">Azarang, Leyla</searchLink><br /><searchLink fieldCode="AR" term="%22Lanfermeijer%2C+Mirthe%22">Lanfermeijer, Mirthe</searchLink><br /><searchLink fieldCode="AR" term="%22Caruso%2C+Marika%22">Caruso, Marika</searchLink><br /><searchLink fieldCode="AR" term="%22Proost%2C+Natalie%22">Proost, Natalie</searchLink><br /><searchLink fieldCode="AR" term="%22Boeije%2C+Manon%22">Boeije, Manon</searchLink><br /><searchLink fieldCode="AR" term="%22Lohuis%2C+Jeroen+O%2E%22">Lohuis, Jeroen O.</searchLink><br /><searchLink fieldCode="AR" term="%22Belthier%2C+Guillaume%22">Belthier, Guillaume</searchLink><br /><searchLink fieldCode="AR" term="%22Noguera+Delgado%2C+Eulàlia%22">Noguera Delgado, Eulàlia</searchLink><br /><searchLink fieldCode="AR" term="%22de+Gruil%2C+Nadia%22">de Gruil, Nadia</searchLink><br /><searchLink fieldCode="AR" term="%22Kroep%2C+Judith+R%2E%22">Kroep, Judith R.</searchLink><br /><searchLink fieldCode="AR" term="%22van+de+Ven%2C+Marieke%22">van de Ven, Marieke</searchLink><br /><searchLink fieldCode="AR" term="%22Menezes%2C+Renee%22">Menezes, Renee</searchLink><br /><searchLink fieldCode="AR" term="%22Wesseling%2C+Jelle%22">Wesseling, Jelle</searchLink><br /><searchLink fieldCode="AR" term="%22Kok%2C+Marleen%22">Kok, Marleen</searchLink><br /><searchLink fieldCode="AR" term="%22Linn%2C+Sabine%22">Linn, Sabine</searchLink><br /><searchLink fieldCode="AR" term="%22Broeks%2C+Annegien%22">Broeks, Annegien</searchLink><br /><searchLink fieldCode="AR" term="%22van+Rossum%2C+Huub+H%2E%22">van Rossum, Huub H.</searchLink><br /><searchLink fieldCode="AR" term="%22Scheele%2C+Colinda+L%2E+G%2E+J%2E%22">Scheele, Colinda L. G. J.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Rheenen%2C+Jacco%22">van Rheenen, Jacco</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Nature; January 2025, Vol. 637 Issue: 8044 p195-204, 10p ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => The response of breast cancer to neoadjuvant chemotherapy (NAC) varies substantially, even when tumours belong to the same molecular or histological subtype1. Here we identify the oestrous cycle as an important contributor to this heterogeneity. In three mouse models of breast cancer, we show reduced responses to NAC when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. Similar findings were observed in retrospective premenopausal cohorts of human patients. Mechanistically, the dioestrus stage exhibits systemic and localized changes, including (1) an increased number of cells undergoing epithelial-to-mesenchymal transition linked to chemoresistance2, 3–4and (2) decreased tumour vessel diameter, suggesting potential constraints to drug sensitivity and delivery. In addition, an elevated presence of macrophages, previously associated with chemoresistance induction5, characterizes the dioestrus phase. Whereas NAC disrupts the oestrous cycle, this elevated macrophage prevalence persists and depletion of macrophages mitigates the reduced therapy response observed when initiating treatment during dioestrus. Our data collectively demonstrate the oestrous cycle as a crucial infradian rhythm determining chemosensitivity, warranting future clinical studies to exploit optimal treatment initiation timing for enhanced chemotherapy outcomes. ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1038/s41586-024-08276-1
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 10
[StartPage] => 195
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bornes, Laura
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van Winden, Lennart J.
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Geurts, Veerle C. M.
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => de Bruijn, Beaunelle
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Azarang, Leyla
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lanfermeijer, Mirthe
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Caruso, Marika
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Proost, Natalie
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Boeije, Manon
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lohuis, Jeroen O.
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Belthier, Guillaume
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Noguera Delgado, Eulàlia
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => de Gruil, Nadia
)
)
)
[13] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kroep, Judith R.
)
)
)
[14] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van de Ven, Marieke
)
)
)
[15] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Menezes, Renee
)
)
)
[16] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wesseling, Jelle
)
)
)
[17] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kok, Marleen
)
)
)
[18] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Linn, Sabine
)
)
)
[19] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Broeks, Annegien
)
)
)
[20] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van Rossum, Huub H.
)
)
)
[21] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Scheele, Colinda L. G. J.
)
)
)
[22] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => van Rheenen, Jacco
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 02
[M] => 01
[Text] => January 2025
[Type] => published
[Y] => 2025
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 00280836
)
[1] => Array
(
[Type] => issn-print
[Value] => 14764687
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 637
)
[1] => Array
(
[Type] => issue
[Value] => 8044
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Nature
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |