Periodical
Polylysine-Induced Rapid Ca2+Release from Cardiac Sarcoplasmic Reticulum
| العنوان: | Polylysine-Induced Rapid Ca2+Release from Cardiac Sarcoplasmic Reticulum |
|---|---|
| المؤلفون: | Yano, Masafumi, Yamamoto, Takeshi, Kohno, Michihiro, Hisaoka, Takayuki, Ono, Kaoru, Tanigawa, Taketo, Ueyama, Takeshi, Ohkusa, Tomoko, Matsuzaki, Masunori |
| المصدر: | Journal of Cardiovascular Pharmacology; July 1998, Vol. 32 Issue: 1 p96-100, 5p |
| مستخلص: | The rapid kinetics of polylysine-induced Ca2+release from cardiac sarcoplasmic reticulum (SR) was assessed in combination with its effect on ryanodine binding. SR vesicles were isolated from canine cardiac SR. The time course of SR Ca2+release was continuously monitored by a stopped-flow apparatus, and [3H]ryanodine binding was done by using the filtration method. The initial rate of polylysine-induced Ca2+release from cardiac SR revealed different concentration dependence from those observed in skeletal SR. The initial rate peaked at 0.11 μM,followed by a decrease at higher concentrations in skeletal SR, whereas it increased to 3.7 μMin cardiac SR. The [3H]ryanodine binding was also stimulated by polylysine with an identical parallelism with Ca2+release in terms of polylysine concentration dependence. Thus we demonstrated that the cardiac SR Ca2+release channel is sensitive to activation by polylysine and that there is a difference in the concentration dependence of polylysine-induced activation of cardiac and skeletal SR Ca2+release channels. |
| قاعدة البيانات: | Supplemental Index |
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