Periodical
Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design
| العنوان: | Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design |
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| المؤلفون: | Choong, I. C., Lew, W., Lee, D., Pham, P., Burdett, M. T., Lam, J. W., Wiesmann, C., Luong, T. N., Fahr, B., DeLano, W. L., McDowell, R. S., Allen, D. A., Erlanson, D. A., Gordon, E. M., O'Brien, T. |
| المصدر: | Journal of Medicinal Chemistry; November 2002, Vol. 45 Issue: 23 p5005-5022, 18p |
| مستخلص: | The design, synthesis, and in vitro activities of a series of potent and selective small-molecule inhibitors of caspase-3 are described. From extended tethering, a salicylic acid fragment was identified as having binding affinity for the S |
| قاعدة البيانات: | Supplemental Index |
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edo Supplemental Index ejs3894454 817 6 Periodical serialPeriodical 816.503601074219 |
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