Academic Journal
Influence of the combination flunixin and marbofloxacin after its intramuscular administration on the pharmacokinetics of marbofloxacin in buffaloes (Preliminary study).
| العنوان: | Influence of the combination flunixin and marbofloxacin after its intramuscular administration on the pharmacokinetics of marbofloxacin in buffaloes (Preliminary study). |
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| المؤلفون: | Baroni, E. E., Rodríguez, C., M. D.San Andrés, Moroni, C., Rubio, S., de Lucas, J. J., San Andrés, M. I. |
| المصدر: | Revista Veterinaria; 2010, Vol. 21 Issue 1, p317-319, 3p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: | INTRAMUSCULAR injections, PHARMACOKINETICS, WATER buffalo, SERUM, BLOOD plasma, JUGULAR vein, HIGH performance liquid chromatography, CHEMICAL kinetics, DRUG metabolism, DRUG dosage |
| مستخلص: | The pharmacokinetics of marbofloxacin was investigated in buffaloes given this drug alone o r in combination with flunixin. The study was carried out in eight (Two group 4 + 4) bu ffaloes (7-15 days old). Marbofloxacin was administered i.m. at a dosage of 2 mg.kg-1 alone o r in conjunction with flunixin (2.5 mg.kg-1, i.m.). For these reasons, pharmacokinetic properties of MB in buffalo calves were determined in serum after intramuscular administration both alone and in combination with flunixin. Blood samples were drawn from the jugular vein at predetermined time intervals after drug injection. Serum was separated and analyzed by reverse-phase high performance liquid chromatography. Plasma levels of marbofloxacin were subjected to model independent analysis, statistical moments were used to compute the non compartmental with the help of PCnonlinâ V 4.0. The peak plasma concentration Cmax , terminal half-life (t1/2l), area under the plasma concentration-time curve (AUC), and mean residence time (MRT) were: Cmax 1.35 ±0.18 vs 0.82±0.0 8; t1/2l 6.60±0.87 vs 9,31 ±1,94 h, AUC 10.71±3.14 vs 10. 04 ±1.18 ìg.h.mL, MRT 7.19 ± 0.75 h vs 8.47±0.90 hours for MB alone and M B + Flunixin, respectively. The kinetic behavior of marbofloxacin in buffaloes was influenced by the co - administration with flunixin, the affected parameters were Cmax and MRT. These modifications could have therapeutic implications from a viewpoint of dose optimization. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Supplemental Index |
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