Academic Journal
Rethinking isolated cleft lip and palate as a syndrome.
العنوان: | Rethinking isolated cleft lip and palate as a syndrome. |
---|---|
المؤلفون: | Koruyucu, Mine, Kasimoğlu, Yelda, Seymen, Figen, Bayram, Merve, Patir, Asli, Ergöz, Nihan, Tuna, Elif B., Gencay, Koray, Deeley, Kathleen, Bussaneli, Diego, Modesto, Adriana, Vieira, Alexandre R. |
المصدر: | Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Apr2018, Vol. 125 Issue 4, p307-312, 6p |
مستخلص: | |
Copyright of Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Supplemental Index |
ResultId |
1 |
---|---|
Header |
edo Supplemental Index 128518042 885 6 Academic Journal academicJournal 885.252990722656 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edo&AN=128518042&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
|
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Rethinking isolated cleft lip and palate as a syndrome.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Koruyucu%2C+Mine%22">Koruyucu, Mine</searchLink><br /><searchLink fieldCode="AR" term="%22Kasimoğlu%2C+Yelda%22">Kasimoğlu, Yelda</searchLink><br /><searchLink fieldCode="AR" term="%22Seymen%2C+Figen%22">Seymen, Figen</searchLink><br /><searchLink fieldCode="AR" term="%22Bayram%2C+Merve%22">Bayram, Merve</searchLink><br /><searchLink fieldCode="AR" term="%22Patir%2C+Asli%22">Patir, Asli</searchLink><br /><searchLink fieldCode="AR" term="%22Ergöz%2C+Nihan%22">Ergöz, Nihan</searchLink><br /><searchLink fieldCode="AR" term="%22Tuna%2C+Elif+B%2E%22">Tuna, Elif B.</searchLink><br /><searchLink fieldCode="AR" term="%22Gencay%2C+Koray%22">Gencay, Koray</searchLink><br /><searchLink fieldCode="AR" term="%22Deeley%2C+Kathleen%22">Deeley, Kathleen</searchLink><br /><searchLink fieldCode="AR" term="%22Bussaneli%2C+Diego%22">Bussaneli, Diego</searchLink><br /><searchLink fieldCode="AR" term="%22Modesto%2C+Adriana%22">Modesto, Adriana</searchLink><br /><searchLink fieldCode="AR" term="%22Vieira%2C+Alexandre+R%2E%22">Vieira, Alexandre R.</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Apr2018, Vol. 125 Issue 4, p307-312, 6p ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => <bold>Objective: </bold>The goal of the present work was to use dental conditions that have been independently associated with cleft lip and palate (CL/P) as a tool to identify a broader collection of individuals to be used for gene identification that lead to clefts.<bold>Study Design: </bold>We studied 1573 DNA samples combining individuals that were born with CL/P or had tooth agenesis, supernumerary teeth, molar incisor hypomineralization, or dental caries with the goal to identify genetic associations. We tested 2 single-nucleotide polymorphisms that were located in the vicinity of regions suggested to contribute to supernumerary teeth. Overrepresentation of alleles were determined for combinations of individuals as well as for each individual phenotypic group with an α of .05.<bold>Results: </bold>We determined that the allele C of rs622260 was overrepresented in all individuals studied compared with a group of unrelated individuals who did not present any of the conditions described earlier. When subgroups were tested, associations were found for individuals with hypomineralization.<bold>Conclusions: </bold>Although we did not test this hypothesis directly in the present study, based on associations reported previously, we believe that CL/P is actually a syndrome of alterations of the dentition, and considering it that way may allow for the identification of genotype-phenotype correlations that may be useful for clinical care. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1016/j.oooo.2018.01.007
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 6
[StartPage] => 307
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Rethinking isolated cleft lip and palate as a syndrome.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Koruyucu, Mine
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kasimoğlu, Yelda
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Seymen, Figen
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bayram, Merve
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Patir, Asli
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ergöz, Nihan
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Tuna, Elif B.
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gencay, Koray
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Deeley, Kathleen
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Bussaneli, Diego
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Modesto, Adriana
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vieira, Alexandre R.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 04
[Text] => Apr2018
[Type] => published
[Y] => 2018
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 22124403
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 125
)
[1] => Array
(
[Type] => issue
[Value] => 4
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |