Academic Journal
Synthesis and anti-HIV-1 activity of new conjugates of 18 β- and 18 α-glycyrrhizic acids with aspartic acid esters.
| العنوان: | Synthesis and anti-HIV-1 activity of new conjugates of 18 β- and 18 α-glycyrrhizic acids with aspartic acid esters. |
|---|---|
| المؤلفون: | Baltina, L., Chistoedova, E., Kondratenko, R., Plyasunova, O. |
| المصدر: | Chemistry of Natural Compounds; May2012, Vol. 48 Issue 2, p262-266, 5p |
| مصطلحات موضوعية: | ASPARTIC acid, BIOSYNTHESIS, ANTIBODY-enzyme conjugates, HIV, DICYCLOHEXYLCARBODIIMIDE, BACTERIAL antigens, CELL culture |
| مستخلص: | New conjugates of 18 β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found that the conjugate of 18 β-GA with Asp(OMe)(OMe) ( 4) at a concentration of 250 μg/mL inhibited effectively RT of HIV-1 and the accumulation of virus antigen p24 in MT-4 cell culture (95-97 %) and protected cells from the cytopathogenic action of the virus. [ABSTRACT FROM AUTHOR] |
| Copyright of Chemistry of Natural Compounds is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
كن أول من يترك تعليقا!