Academic Journal
Electrochemical Behavior of Finasteride on Glassy Carbon Electrode Using Differential Pulse Voltammetric Technique.
| العنوان: | Electrochemical Behavior of Finasteride on Glassy Carbon Electrode Using Differential Pulse Voltammetric Technique. |
|---|---|
| المؤلفون: | Hasan, Mohammed Q., Al-Taee, Amer T., Al-Imam, Mohammed M. A. |
| المصدر: | Analytical & Bioanalytical Electrochemistry; Aug2024, Vol. 16 Issue 8, p752-763, 12p |
| مصطلحات موضوعية: | STANDARD hydrogen electrode, FINASTERIDE, SILVER chloride, BUFFER solutions, POTASSIUM chloride, PLATINUM electrodes, CARBON electrodes |
| مستخلص: | The direct and indirect electrochemical behavior of finasteride was studied using a differential pulse technique coupled with a three-electrode detection system consisting of 2 mm diameter glassy carbon as a working electrode, 2 mm diameter platinum wire as an auxiliary electrode, and silver/silver chloride saturated potassium chloride as reference electrode (Ag/AgCl sat KCl). The finasteride gives a weak reduction peak at -0.68 V. The calibration curve of finasteride was constructed using Briton-Robinson buffer solution (pH = 3), the plot of reduction peak current and concentration gives a linear relationship within the concentration range of 0.999×10-5-19.607×10-5 M, with a correlation coefficient of 0.9903. To increase the sensitivity of the method, an indirect determination of finasteride through its interaction with cupric ion was investigated in acetate buffer solution (pH=2) and followed the decrease in reduction peak current of cupric ion as a result of adding sequence addition of finasteride solution. The calibration curve for finasteride was also constructed for its interaction with cupric ions by measuring the decrease of cupric reduction peak current with the sequence additions of finasteride. The calibration curve was linear within the concentration range of 4.997×10-6-476.191×10-6 M, with a correlation coefficient of 0.9930. The binding constant (K) and the Thermodynamic parameters (ΔG, ΔH, and ΔS) for Cu2+-finasteride interaction were calculated. The suggested method was successfully applied for the determination of finasteride in tablets. [ABSTRACT FROM AUTHOR] |
| Copyright of Analytical & Bioanalytical Electrochemistry is the property of University of Tehran and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
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