Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement.

التفاصيل البيبلوغرافية
العنوان:	Tetrachloromethane Induced Acute Liver Injury in Mice: Biochemical and Histopathological Study of the Hepatoprotective Effect of Hep-X Standardized Botanical Dietary Supplement.
المؤلفون:	Karayildirim, Cinel Koksal, Guner, Adem, Yigitturk, Gurkan, Ince, Iskender, Yasar, Mustafa, Yavasoglu, Nefise Ulku Karabay, Yavasoglu, Altug
المصدر:	Pharmaceutical Chemistry Journal; Mar2023, Vol. 56 Issue 12, p1639-1649, 11p
مصطلحات موضوعية:	LIVER injuries, OXIDANT status, CARBON tetrachloride, TURMERIC, MICE, MILK thistle
مستخلص:	This work was aimed at investigating the hepatoprotective effect of Hep-X, a polyherbal formulation containing Silybum marianum L. (Milk thistle), Rosmarinus officinalis L. (Rosemary), Curcuma longa L. (Turmeric) and Fumaria officinalis L. (Fumitory) as standardized botanical dietary supplement, on mice with CCl4-induced acute liver injury. The total phenolic and flavonoid contents of Hep-X were determined as 0.125 and 0.528 mg/mL, respectively. The quercetin content was determined as 50 µg/mL using HPLC analysis. The total antioxidant capacity showed correlation between the Hep-X concentration and percentage inhibition of free radicals. Hep-X was administered orally at 25, 50 and 100 mg/kg b.w./day against CCl4-induced hepatotoxicity in mice. The hepatic damage was measured using blood biochemical parameters. Animals upon Hep-X treatment exhibited better drug effIcacy in certain blood parameters than silymarin-treated mice. Also, Hep-X administration significantly ameliorated the liver damage by suppressing iNOS expression and apoptosis as well as by recovery of the histological structure. The obtained results suggest that Hep-X is able to significantly alleviate the hepatotoxicity induced by CCl4 in mice, which can be due to antioxidant properties of the polyherbal formulation. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات:	Complementary Index

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