التفاصيل البيبلوغرافية
| العنوان: |
Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case. |
| المؤلفون: |
Lenartowicz, Karina A., Monie, Dileep D., Amrami, Kimberly K., Klein, Christopher J., Giannini, Caterina, Spinner, Robert J. |
| المصدر: |
Acta Neurochirurgica; Apr2023, Vol. 165 Issue 4, p935-945, 11p |
| مصطلحات موضوعية: |
PERIPHERAL nerve tumors, NEUROFIBROMATOSIS 2, SCHWANNOMAS, GENETIC profile, NEUROFIBROMATOSIS 1, TUMORS, NEUROFIBROMA |
| مستخلص: |
Purpose: Hybrid peripheral nerve sheath tumors (HPNST) are a newly recognized class of peripheral nerve sheath tumor, composed of at least two areas characteristic of perineurioma, schwannoma, or neurofibroma. The literature consists only of case reports and small series; therefore, we present an illustrative case and an analysis of all reported cases of HPNST with a perineurioma component in the literature. Methods: A systematic search of the literature was performed to identify all reported cases of hybrid perineurioma-schwannoma or perineurioma-neurofibroma in the world's literature. Individual cases were analyzed for demographics, clinical features, imaging, and outcomes. Results: A total of 159 cases were identified across 41 studies. Hybrid tumors tended to present in mid-adulthood (median 38.5 years), predominantly affected females (57%, 89/156), as a painless (63%, 63/100) mass, or swelling. Ten patients (10/74, 14%) had a history of neurofibromatosis 1, and 2 patients a history of neurofibromatosis 2 (2/74, 3%). The majority (78%, 122/157) of cases occurred superficially, most commonly in the lower extremity (25%, 39/157). Perineurioma-schwannoma was the most reported (86%, 137/159) pathologic diagnosis, with 3 cases presenting with malignant features. Two cases reocurred after resection. Conclusion: HPNST tend to occur in mid-adulthood and present as slowly progressive, painless, superficial masses, with a heterogeneous appearance on imaging. These entities pose a unique diagnostic challenge and likely remain under-recognized in the literature and current clinical practice. They pose low risk of recurrence or malignant transformation, and future work regarding the association with neurofibromatosis and genetic profiles is needed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |