Academic Journal
Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis.
| العنوان: | Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis. |
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| المؤلفون: | Sasaki, Tomoki, Nagashima, Hiroyuki, Okuma, Atsushi, Yamauchi, Takeshi, Yamasaki, Kenshi, Aiba, Setsuya, So, Takanori, Ishii, Naoto, Owada, Yuji, MaruYama, Takashi, Kobayashi, Shuhei |
| المصدر: | Digestive Diseases & Sciences; Apr2022, Vol. 67 Issue 4, p1252-1259, 8p |
| مصطلحات موضوعية: | FUNCTIONAL analysis, HOMEOSTASIS, INTESTINES, TOLL-like receptors, INFLAMMATORY bowel diseases |
| مستخلص: | Background: The Toll-like receptor signaling pathway contributes to the regulation of intestinal homeostasis through interactions with commensal bacteria. Although the transcriptional regulator IκB-ζ can be induced by Toll-like receptor signaling, its role in intestinal homeostasis is still unclear. Aims: To investigate the role of IκB-ζ in gut homeostasis. Methods: DSS-administration induced colitis in control and IκB-ζ-deficient mice. The level of immunoglobulins in feces was detected by ELISA. The immunological population in lamina propria (LP) was analyzed by FACS. Results: IκB-ζ-deficient mice showed severe inflammatory diseases with DSS administration in the gut. The level of IgM in the feces after DSS administration was less in IκB-ζ-deficient mice compared to control mice. Upon administration of DSS, IκB-ζ-deficient mice showed exaggerated intestinal inflammation (more IFN-g-producing CD4+ T cells in LP), and antibiotic treatment canceled this inflammatory phenotype. Conclusion: IκB-ζ plays a crucial role in maintaining homeostasis in the gut. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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