Academic Journal
Effects of Long-Term Pamidronate Treatment on Bone Density and Fracture Rate in 65 Osteogenesis Imperfecta Patients.
| العنوان: | Effects of Long-Term Pamidronate Treatment on Bone Density and Fracture Rate in 65 Osteogenesis Imperfecta Patients. |
|---|---|
| المؤلفون: | Yazan, Hakan, Güneş, Nilay, Akpınar, Evren, Yıldırım, Timur, Özyalvaç, Osman Nuri, Akkaya, Dilek Uludağ, Tuysuz, Beyhan |
| المصدر: | Turkish Archives of Pediatrics; Sep2021, Vol. 56 Issue 5, p474-478, 5p |
| مصطلحات موضوعية: | BONE fracture prevention, DIPHOSPHONATES, OSTEOGENESIS imperfecta, TIME, TREATMENT effectiveness, PRE-tests & post-tests, SYMPTOMS, DESCRIPTIVE statistics, DENSITOMETRY, BONE density, PAIN management, EVALUATION |
| مصطلحات جغرافية: | TURKEY |
| مستخلص: | Objective: Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease characterized by recurrent fractures, blue sclera, and hearing loss. Bisphosphonate treatment has been reported to decrease the annual number of fractures and improve the quality of life in patients with OI. The aim of this study is to evaluate the effect of bisphosphonate treatment in the Turkish OI cohort. Methods: Sixty-five patients with OI, who were treated with pamidronate, were included in this study. The mean treatment duration was 47.1 ± 40 months (range:12-168 months). Bone mineral densitometry (BMD) and the mean number of annual fractures were compared before and after the treatment within groups, and the difference after treatment compared between the OI types. Results: After pamidronate treatment, a significant decrease in the mean annual fracture, along with an increase in BMD Z-score was detected in all patients. Treatment duration did not affect BMD Z-score. However, there was a significant decrease in the mean annual number of fractures after 5 years of treatment (P = .048). After treatment, the decrease in the number of fractures was significant in OI type 3, and the increase in BMD Z-score was significant in OI type 4 when compared with OI type 1. Besides, pamidronate treatment relieved pain, and also corrected the platyspondyly radiologically in all OI groups. Conclusion: We demonstrated that pamidronate treatment improves the quality of life by reducing the number of fractures, relieving pain, and also protecting from deformities in all patients with OI. [ABSTRACT FROM AUTHOR] |
| Copyright of Turkish Archives of Pediatrics is the property of Aves Yayincilik Ltd. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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