Academic Journal
Inhibition of prostate cancer cell growth in vivo with short hairpin RNA targeting SATB1.
| العنوان: | Inhibition of prostate cancer cell growth in vivo with short hairpin RNA targeting SATB1. |
|---|---|
| المؤلفون: | Qiang Wang, Shi‑cheng Hu, Chun‑sheng Yang, Jia‑cun Chen, Jun‑nian Zheng, Xiao‑qing Sun, Jun‑qi Wang |
| المصدر: | Oncology Letters; Dec2017, Vol. 14 Issue 6, p6592-6596, 5p, 1 Black and White Photograph, 2 Charts, 3 Graphs |
| مصطلحات موضوعية: | CANCER cell growth, RNA interference insecticides, CARRIER proteins, BIOLOGICAL dressings, GENE therapy, THERAPEUTICS |
| مستخلص: | Despite previous advances, the treatment options for prostate cancer remain limited. For the purposes of gene knockdown, the utility of RNA interference has been demonstrated and is considered to have therapeutic potential. In the present study, a short hairpin RNA (shRNA) was used to assess the effect of special AT‑rich sequence binding protein (SATB1) downregulation on the growth and metastatic potential of prostate cancer in xenograft nude mice. A plasmid carrying shRNA targeting SATB1, pSilencer‑SATB1‑shRNA, was successfully engineered. Using this plasmid, significant downregulation of SATB1 mRNA and protein expression in the DU145 prostate cancer cells was observed. pSilencer‑SATB1‑shRNA was demonstrated to be markedly efficacious against prostate cancer xenografts in nude mice. These results may lead to a novel method of improving gene therapy efficacy against prostate cancer via regulating the function of SATB1. [ABSTRACT FROM AUTHOR] |
| Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edb Complementary Index 126247580 873 6 Academic Journal academicJournal 873.179931640625 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edb&AN=126247580&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edb&genre=article&issn=17921074&ISBN=&volume=14&issue=6&date=20171201&spage=6592&pages=6592-6596&title=Oncology Letters&atitle=Inhibition%20of%20prostate%20cancer%20cell%20growth%20in%20vivo%20with%20short%20hairpin%20RNA%20targeting%20SATB1.&id=DOI:10.3892/ol.2017.7006 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Inhibition of prostate cancer cell growth in vivo with short hairpin RNA targeting SATB1.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Qiang+Wang%22">Qiang Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Shi‑cheng+Hu%22">Shi‑cheng Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Chun‑sheng+Yang%22">Chun‑sheng Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Jia‑cun+Chen%22">Jia‑cun Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Jun‑nian+Zheng%22">Jun‑nian Zheng</searchLink><br /><searchLink fieldCode="AR" term="%22Xiao‑qing+Sun%22">Xiao‑qing Sun</searchLink><br /><searchLink fieldCode="AR" term="%22Jun‑qi+Wang%22">Jun‑qi Wang</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Oncology Letters; Dec2017, Vol. 14 Issue 6, p6592-6596, 5p, 1 Black and White Photograph, 2 Charts, 3 Graphs ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22CANCER+cell+growth%22">CANCER cell growth</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+interference+insecticides%22">RNA interference insecticides</searchLink><br /><searchLink fieldCode="DE" term="%22CARRIER+proteins%22">CARRIER proteins</searchLink><br /><searchLink fieldCode="DE" term="%22BIOLOGICAL+dressings%22">BIOLOGICAL dressings</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+therapy%22">GENE therapy</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink> ) Array ( [Name] => Abstract [Label] => Abstract [Group] => Ab [Data] => Despite previous advances, the treatment options for prostate cancer remain limited. For the purposes of gene knockdown, the utility of RNA interference has been demonstrated and is considered to have therapeutic potential. In the present study, a short hairpin RNA (shRNA) was used to assess the effect of special AT‑rich sequence binding protein (SATB1) downregulation on the growth and metastatic potential of prostate cancer in xenograft nude mice. A plasmid carrying shRNA targeting SATB1, pSilencer‑SATB1‑shRNA, was successfully engineered. Using this plasmid, significant downregulation of SATB1 mRNA and protein expression in the DU145 prostate cancer cells was observed. pSilencer‑SATB1‑shRNA was demonstrated to be markedly efficacious against prostate cancer xenografts in nude mice. These results may lead to a novel method of improving gene therapy efficacy against prostate cancer via regulating the function of SATB1. [ABSTRACT FROM AUTHOR] ) Array ( [Name] => Abstract [Label] => [Group] => Ab [Data] => <i>Copyright of Oncology Letters is the property of Spandidos Publications UK Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.3892/ol.2017.7006
)
)
[Languages] => Array
(
[0] => Array
(
[Code] => eng
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 5
[StartPage] => 6592
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => CANCER cell growth
[Type] => general
)
[1] => Array
(
[SubjectFull] => RNA interference insecticides
[Type] => general
)
[2] => Array
(
[SubjectFull] => CARRIER proteins
[Type] => general
)
[3] => Array
(
[SubjectFull] => BIOLOGICAL dressings
[Type] => general
)
[4] => Array
(
[SubjectFull] => GENE therapy
[Type] => general
)
[5] => Array
(
[SubjectFull] => THERAPEUTICS
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Inhibition of prostate cancer cell growth in vivo with short hairpin RNA targeting SATB1.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Qiang Wang
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Shi‑cheng Hu
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Chun‑sheng Yang
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jia‑cun Chen
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jun‑nian Zheng
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xiao‑qing Sun
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jun‑qi Wang
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 12
[Text] => Dec2017
[Type] => published
[Y] => 2017
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 17921074
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 14
)
[1] => Array
(
[Type] => issue
[Value] => 6
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Oncology Letters
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |