Lactiplantibacillus plantarum ZJ316–fermented milk ameliorates dextran sulfate sodium–induced chronic colitis by improving the inflammatory response and regulating intestinal microbiota.

التفاصيل البيبلوغرافية
العنوان:	Lactiplantibacillus plantarum ZJ316–fermented milk ameliorates dextran sulfate sodium–induced chronic colitis by improving the inflammatory response and regulating intestinal microbiota.
المؤلفون:	Gu, Qing¹ (AUTHOR), Chen, Ziqi¹ (AUTHOR), Liu, Nana¹ (AUTHOR), Xia, Chenlan¹ (AUTHOR), Zhou, Qingqing¹ (AUTHOR), Li, Ping¹ (AUTHOR) ping-biology@outlook.com
المصدر:	Journal of Dairy Science. Nov2023, Vol. 106 Issue 11, p7352-7366. 15p.
مصطلحات موضوعية:	FERMENTED milk, DEXTRAN sulfate, GUT microbiome, INFLAMMATORY bowel diseases, COLITIS, SHORT-chain fatty acids, MILK microbiology
مستخلص:	The pathogenesis of inflammatory bowel disease may be related to local inflammatory damage and disturbances in intestinal microecology. Probiotic therapy is a safe and effective therapeutic approach. Considering that fermented milk is accepted and enjoyed by many people as a daily dietary intervention strategy, its potential to alleviate dextran sulfate sodium (DSS)–induced chronic colitis in mice needs to be explored. In this study, we evaluated the therapeutic effects of Lactiplantibacillus plantarum ZJ316–fermented milk by establishing a mouse model of DSS-induced chronic colitis. The results showed that the disease severity and colonic lesions of inflammatory bowel disease were effectively alleviated by ingestion of fermented milk. At the same time, the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) effectively decreased, and the expression of antiinflammatory cytokines (IL-10) increased. Results based on 16S rRNA gene sequencing indicated that the structure and diversity of intestinal microorganisms changed markedly by intake of L. plantarum ZJ316–fermented milk, and fermented milk reduced the abundance of harmful bacteria (Helicobacter) while promoting the growth of beneficial bacteria (Faecalibacterium , Lactiplantibacillus , and Bifidobacterium). Additionally, the levels of short-chain fatty acids (acetic acid, propionic acid, butyric acid, pentanoic acid, and isobutyric acid) were also increased. In conclusion, the intake of L. plantarum ZJ316–fermented milk can alleviate chronic colitis by suppressing the inflammatory response and regulating intestinal microbiota. [ABSTRACT FROM AUTHOR]
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