التفاصيل البيبلوغرافية
| العنوان: |
重症急性胰腺炎患者血清CXCL10、CXCR4 表达水平与TLR4/NF-KB/ NLRP3 信号通路及并发肺损伤的关系研究. |
| Alternate Title: |
Study on the Relationship between Serum CXCL10, CXCR4 Expression Levels and TLR4/NF-κB/NLRP3 Signaling Pathway and Lung Injury in Patients with Severe Acute Pancreatitis. |
| المؤلفون: |
申斌1 shenbin19871006@163.com, 陈镇2 chenzhen100876@126.com, 谢觉3, 严峻1, 潘沐勇1 |
| المصدر: |
Progress in Modern Biomedicine. Dec2024, Vol. 24 Issue 23, p4568-4570. 3p. |
| مصطلحات موضوعية: |
*CXCR4 receptors, *MONONUCLEAR leukocytes, *MESSENGER RNA, *TOLL-like receptors, *NLRP3 protein |
| Abstract (English): |
Objective: To investigate the relationship between the expression levels of serum CXC chemokine ligand 10 (CXCL10) and CXC chemokine receptor 4 (CXCR4) and Toll-like receptor 4 (TLR4)/nuclear factor-кВ (NF-кВ)/NOD-like receptor hot protein domain-related protein 3 (NLRP3) signaling pathway and concurrent lung injury in patients with severe acute pancreatitis (SAP). Methods: 157 patients with SAP were divided into damage group (57 cases) and undamaged group (100 cases) according to whether were complicated with lung injury, serum CXCL10, CXCR4 levels, TLR4, NF-κB, and NLRP3 messenger ribonucleic acid (mRNA) expression in peripheral blood mononuclear cells were detected and compared in two groups. The correlation between serum CXCL10, CXCR4 levels and TLR4, NF-κB, NLRP3 mRNA expression in peripheral blood mononuclear cells of SAP patients were analyzed by Pearson method. The influencing factors of SAP patients complicated with lung injury were analyzed by multivariate Logistic regression analysis. Results: The levels of serum CXCL10 and CXCR4 and the expression of TLR4 mRNA, NF-KB mRNA and NLRP3 mRNA in peripheral blood mononuclear cells in damage group were higher than those in undamaged group (P<0.05). The levels of serum CXCL10 and CXCR4 in SAP patients were positively correlated with the expression of TLR4 mRNA, NF-KB mRNA and NLRP3 mRNA in peripheral blood mononuclear cells (P<0.05). Elevated bedside severity index of acute pancreatitis (BISAP) score, hypoproteinemia, and elevated serum CXCL10 and CXCR4 levels were risk factors for lung injury in SAP patients (P<0.05). Conclusion: The levels of serum CXCL10 and CXCR4 in SAP patients are increased, which are closely related to the activation of TLR4/NF-KB/NLRP3 signaling pathway and complicated with lung injury. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
探讨重症急性胰腺炎 (SAP)患者血清CXC趋化因子配体10 (CXCL10), CXC趋化因子受体4 (CXCR4)表达水平与 Toll 样受体4 (TLR4)/核因子KB (NF-kB)/NOD样受体热蛋白结构域相关蛋白3 (NLRP3)信号通路及并发肺损伤的关系。方法: 选取157例 SAP患者, 根据SAP患者是否并发肺损伤将其分为损伤组 (57例)和非损伤组 (100例), 检测并对比两组血清 CXCL10 CXCR4水平, 外周血单个核细胞TLR4, NF-KB, NLRP3信使核糖核酸 (mRNA)表达。Pearson法分析SAP患者血清 CXCL10, CXCR4水平与外周血单个核细胞TLR4 NF-KB, NLRP3mRNA表达的相关性。多因素 Logistic回归分析SAP患者并发 肺损伤的影响因素。结果:损伤组血清CXCL10, CXCR4水平及外周血单个核细胞 TLR4 mRNA NF-KB mRNA, NLRP3 mRNA表 达均高于非损伤组 (P<0.05)。SAP患者血清CXCL10, CXCR4水平与外周血单个核细胞TLR4 mRNA NF-KB mRNA NLRP3 mRNA表达呈正相关 (P<0.05)。急性胰腺炎床旁严重度指数 (BISAP)评分升高, 低蛋白血症, 血清CXCL10, CXCR4水平升高是 SAP患者并发肺损伤的危险因素 (P<0.05)。结论:SAP患者血清CXCL10, CXCR4水平升高, 与TLR4/NF-kB/NLRP3信号通路激 活及并发肺损伤密切相关。 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |