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Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population.

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العنوان: Alu insertion polymorphisms and susceptibility to metabolic syndrome in a Moroccan population.
المؤلفون: Farhane, Hamid1 (AUTHOR), Motrane, Majida1 (AUTHOR), Soufaine, Karchali1 (AUTHOR), Anaibar, Fatima-Ezzahra1 (AUTHOR), Motrane, Aïcha2 (AUTHOR), Abeid, Said Nassor1 (AUTHOR), Hilali, Abderraouf3 (AUTHOR), Harich, Nourdin1 (AUTHOR) harichanthropo@gmail.com
المصدر: Egyptian Journal of Medical Human Genetics. 1/14/2025, Vol. 26 Issue 1, p1-11. 11p.
مصطلحات موضوعية: *GENETIC polymorphisms, *MOROCCANS, *POLYMERASE chain reaction, *METABOLIC syndrome, *ENVIRONMENTAL risk
Abstract (English): Background: Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health condition and increases the difficulty of its diagnosis and treatment. Objective: Our study aimed to explore the association between four Alu insertion polymorphisms and the risk of MetS as well as its components in the Doukkala population of Morocco. Methods: A case–control study was conducted on 175 cases of MetS and 252 controls. Four Alu insertion polymorphisms (Alu-ACE, Alu-TPA25, Alu-PV92, and Alu-APOA1) were genotyped using Polymerase Chain Reaction followed by direct electrophoresis of its products. Results: Our results showed that the Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms are significantly associated with MetS, the patients are characterized by higher frequencies of genotype II (OR = 6.96, 95% CI [4.12–11.75], p < 0.0001) and *Ins allele for Alu-PV92, and DD genotype (OR = 3.32, 95% CI [1.57–7.00], p = 0.001) and *Del allele for Alu-APOA1 compared to controls. Additionally, a significant association was revealed with MetS in men carrying the *Ins allele and the Alu-TPA25 II genotype (OR = 2.11, 95% CI [1.00–4.44], p = 0.0487). Furthermore, our study concluded that the Alu polymorphisms analyzed were linked to several MetS components, such as hyperglycemia, obesity, hypertension, hyperglycemia, and abnormal lipid levels. Conclusion: The Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms were associated with an elevated MetS risk and its components in both women and men from the Doukkala population, while the Alu-TPA25 Ins/Del polymorphism are associated only in men with only some components. These findings hold considerable public health implications, indicating that Alu polymorphisms could serve as biomarkers for identifying individuals at risk of developing MetS. [ABSTRACT FROM AUTHOR]
Abstract (Arabic): تتناول المقالة العلاقة بين أربعة تعدد أشكال إدخال ألو (Alu) وخطر متلازمة الأيض (MetS) في سكان دكالة بالمغرب. أظهرت دراسة حالة وشاهد شملت 175 مريضًا بمتلازمة الأيض و252 شاهدًا ارتباطات هامة بين تعدد أشكال ألو-PV92 و ألو-APOA1 مع زيادة خطر متلازمة الأيض، خاصةً لدى النساء. وجدت الدراسة أن الأفراد الذين يحملون النمط الجيني II لتعدد أشكال ألو-PV92 والنمط الجيني DD لتعدد أشكال ألو-APOA1 أظهروا ترددات أعلى بين مرضى متلازمة الأيض مقارنةً بالشواهد، مما يشير إلى أن هذه التعددات الشكلية يمكن أن تكون بمثابة مؤشرات حيوية محتملة لتحديد الأفراد المعرضين لخطر تطوير متلازمة الأيض. تؤكد النتائج على أهمية العوامل الوراثية في مسببات متلازمة الأيض ومكوناتها، والتي تشمل السمنة وارتفاع ضغط الدم واضطرابات الدهون. [Extracted from the article]
قاعدة البيانات: Academic Search Index
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Array ( [Name] => Abstract [Label] => Abstract (English) [Group] => Ab [Data] => Background: Metabolic syndrome (MetS) is a multifaceted disorder that significantly elevates the cardiovascular disease risk. The diversity of the combination of its main components, conditioned by genetics and environmental risk factors, contributes to the complexity of this health condition and increases the difficulty of its diagnosis and treatment. Objective: Our study aimed to explore the association between four Alu insertion polymorphisms and the risk of MetS as well as its components in the Doukkala population of Morocco. Methods: A case–control study was conducted on 175 cases of MetS and 252 controls. Four Alu insertion polymorphisms (Alu-ACE, Alu-TPA25, Alu-PV92, and Alu-APOA1) were genotyped using Polymerase Chain Reaction followed by direct electrophoresis of its products. Results: Our results showed that the Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms are significantly associated with MetS, the patients are characterized by higher frequencies of genotype II (OR = 6.96, 95% CI [4.12–11.75], p &lt; 0.0001) and *Ins allele for Alu-PV92, and DD genotype (OR = 3.32, 95% CI [1.57–7.00], p = 0.001) and *Del allele for Alu-APOA1 compared to controls. Additionally, a significant association was revealed with MetS in men carrying the *Ins allele and the Alu-TPA25 II genotype (OR = 2.11, 95% CI [1.00–4.44], p = 0.0487). Furthermore, our study concluded that the Alu polymorphisms analyzed were linked to several MetS components, such as hyperglycemia, obesity, hypertension, hyperglycemia, and abnormal lipid levels. Conclusion: The Alu-PV92 and Alu-APOA1 Ins/Del polymorphisms were associated with an elevated MetS risk and its components in both women and men from the Doukkala population, while the Alu-TPA25 Ins/Del polymorphism are associated only in men with only some components. These findings hold considerable public health implications, indicating that Alu polymorphisms could serve as biomarkers for identifying individuals at risk of developing MetS. [ABSTRACT FROM AUTHOR] )
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