Academic Journal
DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1.
| العنوان: | DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1. |
|---|---|
| المؤلفون: | Leung, Justin W.1 (AUTHOR) leungj@uthscsa.edu, Miller, Kyle M.1,2 (AUTHOR) kyle.miller@austin.utexas.edu |
| المصدر: | Trends in Pharmacological Sciences. Nov2024, Vol. 45 Issue 11, p955-957. 3p. |
| مصطلحات موضوعية: | *HOMOLOGOUS recombination, *DNA repair, *DOUBLE-strand DNA breaks, *BRCA genes, *CANCER radiotherapy |
| مستخلص: | Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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