التفاصيل البيبلوغرافية
| العنوان: |
A Novel Synthetic Strategy of 1,4-Benzodiazepine-5-one Derivatives Via Nickel Pyrophosphate (Ni2P2O7) Catalysis. |
| المؤلفون: |
ZIMOU, Omar1 (AUTHOR), EL HALLAOUI, Achraf1 (AUTHOR) achraf.el.hallaoui@uit.ac.ma, MALEK, Badr1 (AUTHOR), GAILANE, Rachida1 (AUTHOR), BOUKHRIS, Said1 (AUTHOR), SOUIZI, Abdelaziz1 (AUTHOR) |
| المصدر: |
Catalysis Letters. Aug2024, Vol. 154 Issue 8, p4535-4545. 11p. |
| مصطلحات موضوعية: |
*HETEROGENEOUS catalysts, *X-ray photoelectron spectroscopy, *ORGANIC chemistry, *NICKEL catalysts, *INFRARED spectroscopy |
| مستخلص: |
This study aims to develop a straightforward, green and effective catalytic method for synthesizing 1,4-benzodiazepine-5-one derivatives, which possess remarkable biological activities. The approach involves anthranilamide reacting with cyano-ester epoxide in free-solvent conditions, using Ni2P2O7 as a new heterogeneous catalyst. This support was introduced and used as a novel heterogeneous catalyst in organic chemistry for the first time which was prepared via the coprecipitation method, involving the modification of Triple super phosphate (TSP) with nickel nitrate (Ni(NO3)2). The characterization of Ni2P2O7 was realized by various spectroscopic techniques such as X-ray diffraction (DRX), infrared spectroscopy (FT-IR), brunauer–emmett–teller (BET), X-ray photoelectron spectroscopy (XPS), Hg-porosimetry and scanning electron microscopy (SEM) coupled with (EDAX). By optimizing reaction conditions, including the solvent and the amount of the catalyst, we achieved excellent yields of up to 95% for 1,4-benzodiazepine-5-one derivatives in a considerably shorter reaction time and green reaction conditions using this innovative synthetic approach which represents a significant improvement over the previous method. Furthermore, the catalytic support shows a long durability by reusing it for at least five cycles without any degradation of its activity. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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