Academic Journal
An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15.
| العنوان: | An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15. |
|---|---|
| المؤلفون: | Chen, Cizhi1,2 (AUTHOR), Kang, Jiao3 (AUTHOR), Wang, Siyi3 (AUTHOR), Chen, Siyu3 (AUTHOR), Guo, Hong2 (AUTHOR), Chen, Mei1 (AUTHOR) 396762073@qq.com |
| المصدر: | Microchimica Acta. Mar2023, Vol. 190 Issue 3, p1-11. 11p. |
| مصطلحات موضوعية: | *HUMAN growth, *MICROTUBULES, *POLYANILINES, *ZINC, *GROWTH differentiation factors, *GOLD nanoparticles |
| مستخلص: | The incidence rate of cardiovascular diseases (CVDs) remains high, and their mortality rate is significantly higher than that of other diseases. Growth differentiation factor-15 (GDF-15) is a recently developed biomarker for the early diagnosis and prognostic evaluation of CVDs because its concentration in serum increases substantially after a cardiovascular injury or an inflammatory reaction. In this study, a sandwich-type immunosensor was constructed for the sensitive detection of GDF-15. Specifically, peony-like zinc gallinate (ZnGa2O4) prepared using a hydrothermal method, which exhibits excellent electrocatalytic performance, was coupled with Au nanoparticles (NPs) to obtain golden-peony-like ZnGa2O4/Au NPs. They preserved the immune activity of GDF-15 antibody molecules and further enhanced the conductivity, thereby realizing additional signal amplification. Hollow polyaniline (PANI) microtubules decorated with Pd NPs were used as the sensing platform (PANI/Pd NPs). The hollow microtubules provided abundant active sites and considerably improved the electron-transfer rate. Under optimal conditions, a linear range and remarkably low detection limit of 100 fg mL−1–10 ng mL−1 and 42.23 fg mL−1, respectively, were achieved. These experimental results indicate that the strategy reported herein can be adopted as a novel approach for the convenient and rapid detection of GDF-15. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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