Academic Journal
Formulation and Sustained-Release of Verapamil Hydrochloride Tablets.
| العنوان: | Formulation and Sustained-Release of Verapamil Hydrochloride Tablets. |
|---|---|
| المؤلفون: | Mahmoud, Zaid Hamid1 Zaidhameed_91@yahoo.com, Mahdi, Ahmed B.2, Alnassar, Yasir S.3, AL-Salman, H. N. K.4 |
| المصدر: | Chemist. Feb2023, Vol. 94 Issue 1, p76-88. 13p. |
| مصطلحات موضوعية: | *VERAPAMIL, *TABLETING, *P-glycoprotein, *SODIUM bicarbonate |
| مستخلص: | Verapamil hydrochloride effervescent tablets are the principal focus of this investigation. Material & Methods: Verapamil hydrochloride floating tablets were made using the direct compression method. HPMC-K15M, karaya gum, sodium bicarbonate, and diluents were homogenized for ten minutes before adding magnesium stearate to each tablet formulation. Each tablet had a total weight of 300 mg. HPMC was utilized in the range of 20- 40 mg, and karaya gum was used in the 40-90 mg range. We used a mortar and pestle for kneading the powder combination for another 5 minutes. A Rimek rotating tablet machine was used to compress the mixture into tablet form. The formulations were tested using a variety of criteria following their production. Results & Discussion: The tablet formulation friability range was between 0.3 ± 0.0064 and 0.59 ± 0.0077%. The manufactured tablet formulation's weight fluctuation is within USP guidelines. The range of thickness was discovered to be 4.1 ± 0.48 to 4.2 ± 0.76 mm. The assay for drug content range was between 96.52 ± 0.35 and 102.13 ± 0.53%. For B1, B5, B6, B9, and B10 at 12 hours, more than 75% of the medication was released. B1 showed a maximum of 30% drug release in the first hour and a steady release for up to 12 hours. One possible explanation for B8's low drug release is the creation of a thick gel barrier on top of the tablet. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: | Academic Search Index |
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