نتائج البحث - "wild type mice"

المساهمون: Del Percio, Claudio, Drinkenburg, Wilhelmu, Lopez, Susanna, Pascarelli, Maria Teresa, Lizio, Roberta, Noce, Giuseppe, Ferri, Raffaele, Bastlund, Jesper Frank, Laursen, Bettina, Christensen, Ditte Zerlang, Pedersen, Jan T, Forloni, Gianluigi, Frasca, Angelisa, Noè, Francesco M, Fabene, Paolo Francesco, Bertini, Giuseppe, Colavito, Valeria, Bentivoglio, Marina, Kelley, Jonathan, Dix, Sophie, Infarinato, Francesco, Soricelli, Andrea, Stocchi, Fabrizio, Richardson, Jill C, Babiloni, Claudio

مصطلحات موضوعية: Active and passive state in wakefulne, Alzheimer’s disease, TASTPM mice, electroencephalography, wild type mice

Relation: info:eu-repo/semantics/altIdentifier/pmid/32955458; info:eu-repo/semantics/altIdentifier/wos/WOS:000582727600020; volume:78; issue:1; firstpage:291-308; journal:JOURNAL OF ALZHEIMER'S DISEASE; http://hdl.handle.net/11573/1497186; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85095116584

الاتاحة: http://hdl.handle.net/11573/1497186
https://doi.org/10.3233/JAD-190351

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13

Academic Journal

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

المؤلفون: Hirata-Fukae, Chiho, Sidahmed, Elkhansa Hassan, Gooskens, Thomas P, Aisen, Paul S, DEWACHTER, Ilse, Devijver, Herman, Van Leuven, Fred, Matsuoka, Yasuji

المصدر: Article

مصطلحات موضوعية: Alzheimer’s disease, Amyloid beta, Beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1), Non-transgenic (wild-type) mice

وصف الملف: application/pdf

Relation: Neuroscience letters, 435 (3) , p. 186 -189; http://hdl.handle.net/1942/30283; 189; 186; 435; 000255527300003

الاتاحة: http://hdl.handle.net/1942/30283
https://doi.org/10.1016/j.neulet.2008.02.032

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14

Academic Journal

Congenital Zika Virus Infection in Immunocompetent Mice Causes Postnatal Growth Impediment and Neurobehavioral Deficits

المؤلفون: Amber M. Paul, Dhiraj Acharya, Biswas Neupane, E. Ashely Thompson, Gabriel Gonzalez-Fernandez, Katherine M. Copeland, Me’Lanae Garrett, Haibei Liu, Mariper E. Lopez, Matthew de Cruz, Alex Flynt, Jun Liao, Yan-Lin Guo, Federico Gonzalez-Fernandez, Parminder J. S. Vig, Fengwei Bai

المصدر: Frontiers in Microbiology, Vol 9 (2018)

مصطلحات موضوعية: Zika, postnatal development, wild-type mice, neuron, behavior, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fmicb.2018.02028/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/5310bdc7f42d485ca368702ff73d98e0

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15

Academic Journal

TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

المؤلفون: Liu, Gang, Haw, Tatt Jhong, Starkey, Malcolm R, Philp, Ashleigh M, Pavlidis, Stelios, Nalkurthi, Christina, Nair, Prema M, Gomez, Henry M, Hanish, Irwan, Hsu, Alan Cy, Hortle, Elinor, Pickles, Sophie, Rojas-Quintero, Joselyn, Estepar, Raul San Jose, Marshall, Jacqueline E, Kim, Richard Y, Collison, Adam M, Mattes, Joerg, Idrees, Sobia, Faiz, Alen, Hansbro, Nicole G, Fukui, Ryutaro, Murakami, Yusuke, Cheng, Hong Sheng, Tan, Nguan Soon, Chotirmall, Sanjay H, Horvat, Jay C, Foster, Paul S, Oliver, Brian Gg, Polverino, Francesca, Ieni, Antonio, Monaco, Francesco, Caramori, Gaetano, Sohal, Sukhwinder S, Bracke, Ken R, Wark, Peter A, Adcock, Ian M, Miyake, Kensuke, Sin, Don D, Hansbro, Philip M

المساهمون: Liu, Gang, Haw, Tatt Jhong, Starkey, Malcolm R, Philp, Ashleigh M, Pavlidis, Stelio, Nalkurthi, Christina, Nair, Prema M, Gomez, Henry M, Hanish, Irwan, Hsu, Alan Cy, Hortle, Elinor, Pickles, Sophie, Rojas-Quintero, Joselyn, Estepar, Raul San Jose, Marshall, Jacqueline E, Kim, Richard Y, Collison, Adam M, Mattes, Joerg, Idrees, Sobia, Faiz, Alen, Hansbro, Nicole G, Fukui, Ryutaro, Murakami, Yusuke, Cheng, Hong Sheng, Tan, Nguan Soon, Chotirmall, Sanjay H, Horvat, Jay C, Foster, Paul S, Oliver, Brian Gg, Polverino, Francesca, Ieni, Antonio, Monaco, Francesco, Caramori, Gaetano, Sohal, Sukhwinder S, Bracke, Ken R, Wark, Peter A, Adcock, Ian M, Miyake, Kensuke, Sin, Don D, Hansbro, Philip M

مصطلحات موضوعية: Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in TLR7-deficient mice, while inhalation of imiquimod, a TLR7-agonist, induces emphysema without CS exposure. This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses CS-induced emphysema, experimental COPD and accumulation of pulmonary mast cells in mice. Lastly, TLR7 mRNA is increased in pre-existing datasets from patients with COPD, while TLR7+ mast cells are increased in COPD lungs and associated with severity of COPD. Our results thus support roles for TLR7 in mediating emphysema and COPD through mast cell activity, and may implicate TLR7 as a potential therapeutic target

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001104729800026; volume:14; issue:1; firstpage:7349; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/11381/2964952; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85176384352

الاتاحة: https://hdl.handle.net/11381/2964952
https://doi.org/10.1038/s41467-023-42913-z

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16

Combination of cassette-dosing and microsampling for reduced animal usage for antibody pharmacokinetics in cynomolgus monkeys, wild-type mice, and human FcRn transgenic mice

المؤلفون: Kazuhisa Ozeki, Miho Nagayasu

المصدر: Pharmaceutical Research. 38:583-592

مصطلحات موضوعية: Animal Use Alternatives, Male, Genetically modified mouse, Transgene, Drug Evaluation, Preclinical, Pharmaceutical Science, Mice, Transgenic, Receptors, Fc, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Animals, Humans, Pharmacology (medical), Dosing, Cetuximab, biology, business.industry, Histocompatibility Antigens Class I, Organic Chemistry, Antibodies, Monoclonal, Wild type mice, 021001 nanoscience & nanotechnology, Infliximab, Macaca fascicularis, Models, Animal, biology.protein, Feasibility Studies, Molecular Medicine, Antibody, 0210 nano-technology, business, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a31d6e46a2d9377c2800475755fa202
https://doi.org/10.1007/s11095-021-03028-6

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17

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome ActivationSummary

المؤلفون: Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Th, T-helper cell, STAT3, signal transducer and activator of transcription 3, Inflammasomes, medicine.medical_treatment, medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, AOM, azoxymethane, GTPase, guanosine triphosphatase, TNF-α, tumor necrosis factor α, WT-T, tumors of wild-type mice, Original Research, IBD, inflammatory bowel disease, Dextran Sulfate, Gastroenterology, Colitis, mRNA, messenger RNA, SM, submucosal, MMP, matrix metalloproteinase, Real-time polymerase chain reaction, WB, Western blot, qPCR, quantitative polymerase chain reaction, RalGAP, Ral guanosine triphosphatase–activating protein, 030211 gastroenterology & hepatology, ASC, apoptosis associated speck-like protein containing a CARD, animal structures, WT-N, normal colon tissues of wild-type mice, CAC, colitis-associated cancer, Intraperitoneal injection, Guanosine, NF-κB, nuclear factor-κB, Down-Regulation, 03 medical and health sciences, Downregulation and upregulation, DSS, dextran sulfate sodium, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Humans, lcsh:RC799-869, KD, knockdown, KO-N, normal colon tissues of RalGAPα2 knockout mice, KO, knockout, Hepatology, Azoxymethane, KO-T, tumors of RalGAPα2 knockout mice, Molecular biology, WT, wild-type, IL, interleukin, Ral, 030104 developmental biology, chemistry, Apoptosis, siRNA, small interfering RNA, Colitis-Associated Cancer, Triphosphatase, lcsh:Diseases of the digestive system. Gastroenterology, NLRP3 Inflammasome, Carcinogenesis, Ral-GTPase Activating Protein (RalGAP)