نتائج البحث - "virulence factors KatG"

1

Academic Journal

Gene ontology enrichment analysis of differentially expressed genes (A) and proteins (B) from Mtb H37Rv.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Gene_ontology_enrichment_analysis_of_differentially_expressed_genes_A_and_proteins_B_from_i_Mtb_i_H37Rv_/14597965

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s005

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2

Academic Journal

Validation of rabbit polyclonal antibodies raised against Mtb ribosomal proteins S18-1 and S18-2.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Validation_of_rabbit_polyclonal_antibodies_raised_against_i_Mtb_i_ribosomal_proteins_S18-1_and_S18-2_/14597953

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s001

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3

Academic Journal

Growth and morphology of Mtb H37Rv and mc 2 6206 in ZLM and ZRM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Growth_and_morphology_of_i_Mtb_i_H37Rv_and_mc_sup_2_sup_6206_in_ZLM_and_ZRM_/14597956

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s002

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4

Academic Journal

Loss of peak fluorescence from redox cofactor F 420 under Zn 2+ -limiting conditions and the association of F 420 loss with Zn 2+ -limited phenotypes.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Loss_of_peak_fluorescence_from_redox_cofactor_F_sub_420_sub_under_Zn_sup_2_sup_-limiting_conditions_and_the_association_of_F_sub_420_sub_loss_with_Zn_sup_2_sup_-limited_phenotypes_/14597971

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s007

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5

Academic Journal

Pie charts showing KEGG pathways of DE genes in ZLM vs. ZRM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Pie_charts_showing_KEGG_pathways_of_DE_genes_in_ZLM_vs_ZRM_/14597968

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s006

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6

Academic Journal

Multi-dimensional scaling (MDS) plots for Mtb H37Rv transcriptomics (A) and proteomics (B).

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Multi-dimensional_scaling_MDS_plots_for_i_Mtb_i_H37Rv_transcriptomics_A_and_proteomics_B_/14597959

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s003

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7

Academic Journal

Heatmap of tRNA molecules detected in RNAseq of Mtb H37Rv.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Heatmap_of_tRNA_molecules_detected_in_RNAseq_of_i_Mtb_i_H37Rv_/14597962

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s004

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8

Academic Journal

Clumping of cells in ZLM observed with scanning electron microscopy (SEM).

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Clumping_of_cells_in_ZLM_observed_with_scanning_electron_microscopy_SEM_/14597980

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s009

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9

Academic Journal

Detection of KatG protein in lysates from Mtb mc 2 6206 in ZRM and ZLM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Detection_of_KatG_protein_in_lysates_from_i_Mtb_i_mc_sup_2_sup_6206_in_ZRM_and_ZLM_/14597986

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s011

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10

Academic Journal

Genes belonging to KEGG metabolic pathways that are upregulated (red) or downregulated (blue) in ZLM vs. ZRM and superimposed onto a global metabolic network.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Genes_belonging_to_KEGG_metabolic_pathways_that_are_upregulated_red_or_downregulated_blue_in_ZLM_vs_ZRM_and_superimposed_onto_a_global_metabolic_network_/14597974

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s008

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11

Academic Journal

Survival of Mtb mc 2 6206 after growth in ZRM (black) or ZLM (grey) and subsequent exposure to the indicated antibiotics.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Survival_of_i_Mtb_i_mc_sup_2_sup_6206_after_growth_in_ZRM_black_or_ZLM_grey_and_subsequent_exposure_to_the_indicated_antibiotics_/14597992

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s012

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12

Academic Journal

Controls for flow cytometry killing experiment showing gating strategy for bacteria based on forward vs. side scatter and bacteria stained with the live cell stain Calcein-AM (C-AM) and the dead cell stain SYTOX.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Controls_for_flow_cytometry_killing_experiment_showing_gating_strategy_for_bacteria_based_on_forward_vs_side_scatter_and_bacteria_stained_with_the_live_cell_stain_Calcein-AM_C-AM_and_the_dead_cell_stain_SYTOX_/14597983

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s010

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13

Academic Journal

Bacterial burden and histopathology scores from the livers and spleens of mice after 30 days of infection with Mtb H37Rv pre-grown in ZRM or ZLM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Bacterial_burden_and_histopathology_scores_from_the_livers_and_spleens_of_mice_after_30_days_of_infection_with_i_Mtb_i_H37Rv_pre-grown_in_ZRM_or_ZLM_/14598001

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s015

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14

Academic Journal

Schematic of mouse infection experiment with Mtb H37Rv pre-grown in ZRM or ZLM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Schematic_of_mouse_infection_experiment_with_i_Mtb_i_H37Rv_pre-grown_in_ZRM_or_ZLM_/14597995

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s013

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15

Academic Journal

Histopathology scores from the lungs (A), livers (B), and spleens (C) of mice after 15 days of infection with Mtb H37Rv pre-grown in ZRM or ZLM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Histopathology_scores_from_the_lungs_A_livers_B_and_spleens_C_of_mice_after_15_days_of_infection_with_i_Mtb_i_H37Rv_pre-grown_in_ZRM_or_ZLM_/14597998

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s014

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16

Academic Journal

Materials and Methods.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/journal_contribution/Materials_and_Methods_/14598037

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s027

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17

Differentially expressed proteins in ZLM vs. ZRM.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/dataset/Differentially_expressed_proteins_in_ZLM_vs_ZRM_/14598016

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s020

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18

Concentration of CP in sputum samples from TB patients.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/dataset/Concentration_of_CP_in_sputum_samples_from_TB_patients_/14598004

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s016

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19

Assignment of DE genes upregulated in ZLM to KEGG pathways.

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/dataset/Assignment_of_DE_genes_upregulated_in_ZLM_to_KEGG_pathways_/14598019

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.s021

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20

Image

Zn 2+ -limited Mtb exhibit increased resistance to oxidative stress in vitro and cause higher bacterial burden and pathology in vivo .

المؤلفون: Allexa Dow (5130722), Preeti Sule (88095), Timothy J. O’Donnell (7298786), Andrew Burger (10802932), Joshua T. Mattila (9923270), Brandi Antonio (10802935), Kevin Vergara (10802938), Endrei Marcantonio (10802941), L. Garry Adams (10802944), Nicholas James (53967), Philip G. Williams (307047), Jeffrey D. Cirillo (8113991), Sladjana Prisic (112343)

Relation: https://figshare.com/articles/figure/Zn_sup_2_sup_-limited_i_Mtb_i_exhibit_increased_resistance_to_oxidative_stress_i_in_vitro_i_and_cause_higher_bacterial_burden_and_pathology_i_in_vivo_i_/14598052

الاتاحة: https://doi.org/10.1371/journal.ppat.1009570.g005

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