المؤلفون: Biewenga, Lieuwe, Thangavelu, Saravanan, Kunzendorf, Andreas, Van Der Meer, Jan-ytzen, Pijning, Tjaard, Tepper, Pieter, Van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-mark W.h., Poelarends, Gerrit J.

المصدر: Biewenga , L , Thangavelu , S , Kunzendorf , A , Van Der Meer , J , Pijning , T , Tepper , P , Van Merkerk , R , Charnock , S J , Thunnissen , A W H & Poelarends , G J 2019 , ' Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions ' , ACS Catalysis , vol. 9 , pp. 1503-1513 . https://doi.org/10.1021/acscatal.8b04299

مصطلحات موضوعية: Systems biocatalysis, cascades, "Michaelase", gamma-aminobutyric acids, gamma-nitrobutyric acids, enzyme engineering, pharmaceuticals, 4-OXALOCROTONATE TAUTOMERASE, MUTABILITY LANDSCAPES, ADDITION-REACTIONS, CATALYSIS, ACETALDEHYDE, REDUCTION, ALDEHYDES

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/dd72f9b5-d001-4ba8-acb8-993313a48391
https://research.rug.nl/en/publications/dd72f9b5-d001-4ba8-acb8-993313a48391
https://doi.org/10.1021/acscatal.8b04299
https://pure.rug.nl/ws/files/101328770/acscatal.8b04299_2_.pdf

المؤلفون: Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, van der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.

المصدر: ACS catalysis 9(2), 1503 - 1513 (2019). doi:10.1021/acscatal.8b04299

مصطلحات موضوعية: info:eu-repo/classification/ddc/540

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:30740262; info:eu-repo/semantics/altIdentifier/wos/WOS:000458707000074; info:eu-repo/semantics/altIdentifier/issn/2155-5435; https://bib-pubdb1.desy.de/record/421306; https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2019-01946%22

الاتاحة: https://bib-pubdb1.desy.de/record/421306
https://bib-pubdb1.desy.de/search?p=id:%22PUBDB-2019-01946%22

المؤلفون: Gardini, Cristina, Boccardi, Giovanni, Guerrini, Marco, Kellenbach, Edwin, Lunenburg, Maarten, van der Meer, Jan-Ytzen, Naggi, Annamaria, Urso, Elena

المصدر: Thrombosis and Haemostasis ; volume 123, issue 09, page 856-866 ; ISSN 0340-6245 2567-689X

الاتاحة: http://dx.doi.org/10.1055/s-0043-1768225
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-1768225.pdf

المؤلفون: Gardini, Cristina, Boccardi, Giovanni, Guerrini, Marco, Kellenbach, Edwin, Lunenburg, Maarten, van der Meer, Jan-Ytzen, Naggi, Annamaria, Urso, Elena

المصدر: Thrombosis & Haemostasis; Sep2023, Vol. 123 Issue 9, p856-866, 11p

المؤلفون: Rahimi, Mehran, Geertsema, Edzard M, Miao, Yufeng, van der Meer, Jan-Ytzen, Bosch, van den, Thea, de Haan, Pim, Zandvoort, Ellen, Poelarends, Gerrit J

المصدر: Rahimi , M , Geertsema , E M , Miao , Y , van der Meer , J-Y , Bosch, van den , T , de Haan , P , Zandvoort , E & Poelarends , G J 2017 , ' Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase ' , Organic & Biomolecular Chemistry . https://doi.org/10.1039/c7ob00302a

مصطلحات موضوعية: Journal Article

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/44499923-1cc0-4bca-a320-b00b25053e87

الاتاحة: https://hdl.handle.net/11370/44499923-1cc0-4bca-a320-b00b25053e87
https://research.rug.nl/en/publications/44499923-1cc0-4bca-a320-b00b25053e87
https://doi.org/10.1039/c7ob00302a
https://pure.rug.nl/ws/files/40657866/C7OB00302A.pdf

المؤلفون: Rahimi, Mehran, van der Meer, Jan-Ytzen, Geertsema, Edzard M, Poelarends, Gerrit J

المصدر: Rahimi , M , van der Meer , J-Y , Geertsema , E M & Poelarends , G J 2017 , ' Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes ' , ChemBioChem , pp. 1435-1441 . https://doi.org/10.1002/cbic.201700121

مصطلحات موضوعية: Journal Article

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/134f9d89-c6de-4860-b03a-f6441d0ceaba

الاتاحة: https://hdl.handle.net/11370/134f9d89-c6de-4860-b03a-f6441d0ceaba
https://research.rug.nl/en/publications/134f9d89-c6de-4860-b03a-f6441d0ceaba
https://doi.org/10.1002/cbic.201700121
https://pure.rug.nl/ws/files/50328134/Rahimi_et_al_2017_ChemBioChem.pdf

المؤلفون: van der Meer, Jan-Ytzen, Poddar, Harshwardhan, Baas, Bert-Jan, Miao, Yufeng, Rahimi, Mehran, Kunzendorf, Andreas, van Merkerk, Ronald, Tepper, Pieter G, Geertsema, Edzard M, Thunnissen, Andy-Mark W H, Quax, Wim J, Poelarends, Gerrit J

المصدر: van der Meer , J-Y , Poddar , H , Baas , B-J , Miao , Y , Rahimi , M , Kunzendorf , A , van Merkerk , R , Tepper , P G , Geertsema , E M , Thunnissen , A-M W H , Quax , W J & Poelarends , G J 2016 , ' Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases ' , Nature Communications , vol. 7 , 10911 . https://doi.org/10.1038/ncomms10911

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/c9bf7fbd-ec90-499c-ad7c-3b21701f14f9
https://research.rug.nl/en/publications/c9bf7fbd-ec90-499c-ad7c-3b21701f14f9
https://doi.org/10.1038/ncomms10911
https://pure.rug.nl/ws/files/48413058/ncomms10911.pdf

المؤلفون: van der Meer, Jan-Ytzen, Biewenga, Lieuwe, Poelarends, Gerrit J

المصدر: van der Meer , J-Y , Biewenga , L & Poelarends , G J 2016 , ' The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering ' , ChemBioChem , vol. 17 , no. 19 , pp. 1792-1799 . https://doi.org/10.1002/cbic.201600382

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/8f96a8d2-12f4-4d8c-bce6-7baf9a54f3e0
https://research.rug.nl/en/publications/8f96a8d2-12f4-4d8c-bce6-7baf9a54f3e0
https://doi.org/10.1002/cbic.201600382
https://pure.rug.nl/ws/files/36055105/Meer_et_al_2016_ChemBioChem.pdf

المؤلفون: Rahimi, Mehran, van der Meer, Jan-Ytzen, Geertsema, Edzard M, Poddar, Harshwardhan, Baas, Bert-Jan, Poelarends, Gerrit J

المصدر: Rahimi , M , van der Meer , J-Y , Geertsema , E M , Poddar , H , Baas , B-J & Poelarends , G J 2016 , ' Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations ' , ChemBioChem , vol. 17 , no. 13 , pp. 1225-1228 . https://doi.org/10.1002/cbic.201600149

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/7761884a-961d-476e-bbdb-2485fbfa87c3

الاتاحة: https://hdl.handle.net/11370/7761884a-961d-476e-bbdb-2485fbfa87c3
https://research.rug.nl/en/publications/7761884a-961d-476e-bbdb-2485fbfa87c3
https://doi.org/10.1002/cbic.201600149
https://pure.rug.nl/ws/files/79156693/Mutations_Closer_to_the_Active_Site_Improve_the_Promiscuous_Aldolase_Activity.pdf

المؤلفون: Ourailidou, Marilena, van der Meer, Jan-Ytzen, Baas, Bert-Jan, Jeronimus-Stratingh, Catherine, Gottumukkala, Aditya L., Poelarends, Gerrit J., Minnaard, Adriaan J., Dekker, Frans

المصدر: Ourailidou , M , van der Meer , J-Y , Baas , B-J , Jeronimus-Stratingh , C , Gottumukkala , A L , Poelarends , G J , Minnaard , A J & Dekker , F 2014 , ' Aqueous Oxidative Heck Reaction as a Protein-Labeling Strategy ' , ChemBioChem , vol. 15 , no. 2 , pp. 209-212 . https://doi.org/10.1002/cbic.201300714

مصطلحات موضوعية: cross-coupling, Heck reaction, homogeneous catalysis, palladium, protein modifications, CLICK CHEMISTRY, CHEMICAL REPORTERS, OLEFINS, TOOL

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/c44d4426-a7e5-4cb8-b02a-3cca3702f535

الاتاحة: https://hdl.handle.net/11370/c44d4426-a7e5-4cb8-b02a-3cca3702f535
https://research.rug.nl/en/publications/c44d4426-a7e5-4cb8-b02a-3cca3702f535
https://doi.org/10.1002/cbic.201300714
https://pure.rug.nl/ws/files/13092625/209_ftp.pdf
http://www.interscience.wiley.com/

المؤلفون: van der Meer, Jan Ytzen, van der Meer, Jan Ytzen

المصدر: van der Meer , J Y 2016 , ' Mutability-landscape guided enzyme engineering : Improving the promiscuous C-C bond-forming activities of 4-oxalocrotonate tautomerase ' , Doctor of Philosophy , University of Groningen , [Groningen] .

مصطلحات الفهرس: doctoralThesis

URL: http://hdl.handle.net/11370/2cb8da6b-e928-4957-a881-141da4f48766

المؤلفون: Rahimi, Mehran, van der Meer, Jan‐Ytzen, Geertsema, Edzard M., Poddar, Harshwardhan, Baas, Bert‐Jan, Poelarends, Gerrit J.

المصدر: ChemBioChem ; volume 17, issue 13, page 1290-1290 ; ISSN 1439-4227 1439-7633

الاتاحة: https://doi.org/10.1002/cbic.201600321
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbic.201600321
https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201600321

المؤلفون: van der Meer, Jan Ytzen

المساهمون: Poelarends, Gerrit, Quax, W. J., Chemical and Pharmaceutical Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=narcis______::bf922301d6fb92e37714fd9fbd7b4db0
https://research.rug.nl/en/publications/2cb8da6b-e928-4957-a881-141da4f48766

المؤلفون: Hummel, H, van der Meer, Jan Ytzen, de Vries, J., Otter, R

المصدر: Hummel , H , van der Meer , J Y , de Vries , J & Otter , R 2009 , Integrale oncologische zorgpaden. Opzet en toepassing . Koninklijke Van Gorcum , Assen .

الاتاحة: http://hdl.handle.net/11370/a5025791-9181-40f4-88bd-1bfe8727aec7
https://research.rug.nl/en/publications/integrale-oncologische-zorgpaden-opzet-en-toepassing(a5025791-9181-40f4-88bd-1bfe8727aec7).html

المؤلفون: van der Meer, Jan-Ytzen, Hirsch, Anna K. H.

المصدر: van der Meer , J-Y & Hirsch , A K H 2012 , ' The isoprenoid-precursor dependence of Plasmodium spp ' , Natural product reports , vol. 29 , no. 7 , pp. 721-728 . https://doi.org/10.1039/c2np20013a

مصطلحات موضوعية: NON-MEVALONATE PATHWAY, INTRAERYTHROCYTIC STAGES, PROTEIN FARNESYLTRANSFERASE, PARASITE DEVELOPMENT, ELECTRON-TRANSPORT, MALARIA PARASITES, FALCIPARUM, BIOSYNTHESIS, ANTIMALARIAL, FOSMIDOMYCIN

الاتاحة: https://hdl.handle.net/11370/ddb0c918-0a4a-485b-8652-8896e67a5bab
https://research.rug.nl/en/publications/ddb0c918-0a4a-485b-8652-8896e67a5bab
https://doi.org/10.1039/c2np20013a

المؤلفون: van Hoeve, J.C., Otter, R, Hummel, H.J, van der Meer, Jan Ytzen, de Vries, J.

المساهمون: Operations Management & Operations Research

المصدر: Kwaliteit in Zorg, tijdschrift over kwaliteit en veiligheid in de zorg, 20(12), 9-14

URL الوصول: https://explore.openaire.eu/search/publication?articleId=narcis______::e413d078fb5d67eaf84242e0055950c2
https://research.rug.nl/en/publications/60f2a500-9a50-445c-915a-a74245ca32e5

المؤلفون: van der Meer, Jan-Ytzen¹ jvandermeer@nl.aspenpharma.com, Kellenbach, Edwin¹ ekellenbach@nl.aspenpharma.com, van den Bos, Leendert J.¹ lvandenbos@nl.aspenpharma.com

المصدر: Molecules. Jun2017, Vol. 22 Issue 6, p1025. 13p. 5 Diagrams, 2 Charts, 1 Graph.

مصطلحات موضوعية: *HEPARIN, *ANTICOAGULANTS, *BIOTECHNOLOGY, *PHARMACEUTICAL industry, *TISSUES

المؤلفون: van der Meer, Jan‐Ytzen, Biewenga, Lieuwe, Poelarends, Gerrit J.

المصدر: ChemBioChem; 10/4/2016, Vol. 17 Issue 19, p1792-1799, 8p

المؤلفون: Ourailidou, Maria Eleni, van der Meer, Jan‐Ytzen, Baas, Bert‐Jan, Jeronimus‐Stratingh, Margot, Gottumukkala, Aditya L., Poelarends, Gerrit J., Minnaard, Adriaan J., Dekker, Frank J.

المصدر: ChemBioChem; Jan2014, Vol. 15 Issue 2, p209-212, 4p

المؤلفون: Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, Van Der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., Van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.

مصطلحات موضوعية: 3. Good health

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cbf41c046b8381d228609bf323600068