المؤلفون: Mohamed, Abdulfataah A.A., Walland, Peter, Stevens, Jasper, van Londen, Marco, Heerspink, Hiddo J.L., Gansevoort, Ron T., van de Merbel, Nico C.

المصدر: Mohamed , A A A , Walland , P , Stevens , J , van Londen , M , Heerspink , H J L , Gansevoort , R T & van de Merbel , N C 2024 , ' A validated LC-MS/MS method for the simultaneous quantification of iothalamate and hippuran in serum and urine for non-radioactive kidney function assessment ' , Journal of Chromatography B , vol. 1247 , 124329 . https://doi.org/10.1016/j.jchromb.2024.124329

مصطلحات موضوعية: IOTHALAMATE, Hippuran, exogenous filtration marker, non-radioactive, kidney function, mGFR, ERPF, LC-MS/MS, validation of a method

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/bbc05c3d-379f-4abe-aaab-5b343ba4bad7
https://research.rug.nl/en/publications/bbc05c3d-379f-4abe-aaab-5b343ba4bad7
https://doi.org/10.1016/j.jchromb.2024.124329
https://pure.rug.nl/ws/files/1153084001/Mohamed_et_al_LCMSMS_iothalamate_and_hippuran_serum_urine_JChromB_2024.pdf

المؤلفون: Sleumer, Bas, van Faassen, Martijn, Vos, Michel J., den Besten, Gijs, Kema, Ido P., van de Merbel, Nico C.

المصدر: Sleumer , B , van Faassen , M , Vos , M J , den Besten , G , Kema , I P & van de Merbel , N C 2024 , ' Simultaneous quantification of the 22-kDa isoforms of human growth hormone 1 and 2 in human plasma by multiplexed immunocapture and LC-MS/MS ' , Clinica chimica acta , vol. 554 , 117736 . https://doi.org/10.1016/j.cca.2023.117736

مصطلحات موضوعية: Biomarker, Human growth hormone 1, Human growth hormone 2, Immunocapture, Isoform, Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/adf608cc-de1f-4ce2-a11c-c56fc001e8da
https://research.rug.nl/en/publications/adf608cc-de1f-4ce2-a11c-c56fc001e8da
https://doi.org/10.1016/j.cca.2023.117736
https://pure.rug.nl/ws/files/931112944/Simultaneous_quantification_of_the_22-kDa_isoforms_of_human_growth_hormone_1_and_2_in_human_plasma_by_multiplexed_immunocapture_and_LC-MS_MS_.pdf
http://www.scopus.com/inward/record.url?scp=85182455202&partnerID=8YFLogxK

المؤلفون: Sleumer, Bas, Kema, Ido P, van de Merbel, Nico C

المصدر: Sleumer , B , Kema , I P & van de Merbel , N C 2023 , ' Quantitative bioanalysis of proteins by digestion and LC-MS/MS : the use of multiple signature peptides ' , Bioanalysis , vol. 15 , no. 19 , pp. 1203-1216 . https://doi.org/10.4155/bio-2023-0129

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/fe868a36-dd90-4c00-84ec-6378d93533fb
https://research.rug.nl/en/publications/fe868a36-dd90-4c00-84ec-6378d93533fb
https://doi.org/10.4155/bio-2023-0129
https://pure.rug.nl/ws/files/846939543/sleumer-et-al-2023-quantitative-bioanalysis-of-proteins-by-digestion-and-lc-ms-ms-the-use-of-multiple-signature-peptides.pdf

المؤلفون: Sleumer, Bas, Zwerwer, Jordan, Van Faassen, Martijn, Vos, Michel J., Bischoff, Rainer, Kema, Ido P., Van De Merbel, Nico C.

المصدر: Sleumer , B , Zwerwer , J , Van Faassen , M , Vos , M J , Bischoff , R , Kema , I P & Van De Merbel , N C 2023 , ' An antibody-free LC-MS/MS method for the quantification of sex hormone binding globulin in human serum and plasma ' , Clinical chemistry and laboratory medicine , vol. 61 , no. 7 , pp. 1266–1274 . https://doi.org/10.1515/cclm-2022-1225

مصطلحات موضوعية: albumin depletion, biomarker, human sex hormone binding globulin (SHBG), liquid chromatography-Tandem mass spectrometry (LC-MS/MS)

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/563e0b36-3623-4eb3-9992-636cdf946c8a
https://research.rug.nl/en/publications/563e0b36-3623-4eb3-9992-636cdf946c8a
https://doi.org/10.1515/cclm-2022-1225
https://pure.rug.nl/ws/files/672412797/10.1515_cclm_2022_1225_1_.pdf

المؤلفون: Olaleye, Oladapo, Spanov, Baubek, Bults, Peter, Voort, Anna van der, Govorukhina, Natalia, Sonke, Gabe S, Horvatovich, Peter, van de Merbel, Nico C, Bischoff, Rainer

المصدر: Olaleye , O , Spanov , B , Bults , P , Voort , A V D , Govorukhina , N , Sonke , G S , Horvatovich , P , van de Merbel , N C & Bischoff , R 2023 , ' Biotransformation of Trastuzumab and Pertuzumab in Breast Cancer Patients assessed by Affinity Enrichment and Ion Exchange Chromatography ' , Drug Metabolism and Disposition , vol. 50 , no. 12 , pp. 249-256 . https://doi.org/10.1124/dmd.122.001094

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/de84de11-0a42-40fd-b01c-be0b04d60f7e
https://research.rug.nl/en/publications/de84de11-0a42-40fd-b01c-be0b04d60f7e
https://doi.org/10.1124/dmd.122.001094
https://pure.rug.nl/ws/files/589833664/249.full.pdf

المؤلفون: Spanov, Baubek, Baartmans, Bas, Olaleye, Oladapo, Nicolardi, Simone, Govorukhina, Natalia, Wuhrer, Manfred, van de Merbel, Nico C, Bischoff, Rainer

المصدر: Spanov , B , Baartmans , B , Olaleye , O , Nicolardi , S , Govorukhina , N , Wuhrer , M , van de Merbel , N C & Bischoff , R 2023 , ' Revealing charge heterogeneity of stressed trastuzumab at the subunit level ' , Analytical and Bioanalytical Chemistry , vol. 415 , no. 8 , pp. 1505-1513 . https://doi.org/10.1007/s00216-023-04547-4

مصطلحات موضوعية: Trastuzumab, Antibodies, Monoclonal/chemistry, Chromatography, Liquid, Papain, Tandem Mass Spectrometry

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/85dd931a-0029-4c18-b779-53e78afd3229
https://research.rug.nl/en/publications/85dd931a-0029-4c18-b779-53e78afd3229
https://doi.org/10.1007/s00216-023-04547-4
https://pure.rug.nl/ws/files/847077777/s00216-023-04547-4.pdf

المؤلفون: Spanov, Baubek, Olaleye, Oladapo, Mesurado, Tomés, Govorukhina, Natalia, Jungbauer, Alois, van de Merbel, Nico C, Lingg, Nico, Bischoff, Rainer

المصدر: Spanov , B , Olaleye , O , Mesurado , T , Govorukhina , N , Jungbauer , A , van de Merbel , N C , Lingg , N & Bischoff , R 2023 , ' Pertuzumab Charge Variant Analysis and Complementarity-Determining Region Stability Assessment to Deamidation ' , Analytical Chemistry , vol. 95 , no. 8 , pp. 3951-3958 . https://doi.org/10.1021/acs.analchem.2c03275

مصطلحات موضوعية: Humans, Female, Complementarity Determining Regions, Pyrrolidonecarboxylic Acid, Antibodies, Monoclonal, Humanized, Trastuzumab, Breast Neoplasms/drug therapy, Receptor, ErbB-2

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/917bd59f-6212-4862-8164-99d93b69bf48
https://research.rug.nl/en/publications/917bd59f-6212-4862-8164-99d93b69bf48
https://doi.org/10.1021/acs.analchem.2c03275
https://pure.rug.nl/ws/files/847089729/spanov-et-al-2023-pertuzumab-charge-variant-analysis-and-complementarity-determining-region-stability-assessment-to.pdf

المؤلفون: Olaleye, Oladapo, Graf, Christian, Spanov, Baubek, Govorukhina, Natalia, Groves, Matthew R, van de Merbel, Nico C, Bischoff, Rainer

المصدر: Olaleye , O , Graf , C , Spanov , B , Govorukhina , N , Groves , M R , van de Merbel , N C & Bischoff , R 2023 , ' Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry ' , Journal of the American Society for Mass Spectrometry , vol. 34 , no. 4 , pp. 775-783 . https://doi.org/10.1021/jasms.3c00069

مصطلحات موضوعية: Trastuzumab, Hydrogen Deuterium Exchange-Mass Spectrometry, Deuterium, Deuterium Exchange Measurement/methods, Molecular Docking Simulation, Mass Spectrometry/methods, Binding Sites, Hydrogen/chemistry

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/3142988c-9476-4d57-9652-b3eaf678943d
https://research.rug.nl/en/publications/3142988c-9476-4d57-9652-b3eaf678943d
https://doi.org/10.1021/jasms.3c00069
https://pure.rug.nl/ws/files/718970906/jasms.3c00069.pdf

المؤلفون: Spanov, Baubek, Aboagye, Victoria, Olaleye, Oladapo, Govorukhina, Natalia, van de Merbel, Nico C., Bischoff, Rainer

Relation: https://zenodo.org/communities/eu; https://doi.org/10.3389/fchem.2021.794247; oai:zenodo.org:6778576

الاتاحة: https://doi.org/10.3389/fchem.2021.794247

المؤلفون: Sleumer, Bas, van Faassen, Martijn, Vos, Michel J., Bischoff, Rainer, Kema, Ido P., van de Merbel, Nico C.

المصدر: Sleumer , B , van Faassen , M , Vos , M J , Bischoff , R , Kema , I P & van de Merbel , N C 2022 , ' Selective quantification of the 22-kDa isoform of human growth hormone 1 in serum and plasma by immunocapture and LC-MS/MS ' , Analytical and Bioanalytical Chemistry , vol. 414 , pp. 6187-6200 . https://doi.org/10.1007/s00216-022-04188-z

مصطلحات موضوعية: Human growth hormone, Liquid chromatography-tandem mass spectrometry (LC-MS/MS), Biomarker, Immunocapture, Isoform, MASS-SPECTROMETRY, INTERFERENCE, PROTEIN, GH

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/9869fe9f-d329-43c5-b928-72d592b76627
https://research.rug.nl/en/publications/9869fe9f-d329-43c5-b928-72d592b76627
https://doi.org/10.1007/s00216-022-04188-z
https://pure.rug.nl/ws/files/230620679/Selective_quantification_of_the_22_kDa_isoform_of_human_growth_hormone_1_in_serum_and_plasma_by_immunocapture_and_LC_MS_MS.pdf

المؤلفون: Bults, Peter, van der Voort, Anna, Meijer, Coby, Sonke, Gabe S, Bischoff, Rainer, van de Merbel, Nico C

المصدر: Bults , P , van der Voort , A , Meijer , C , Sonke , G S , Bischoff , R & van de Merbel , N C 2022 , ' Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab ' , Analytical and Bioanalytical Chemistry , vol. 414 , no. 4 , pp. 1513–1524 . https://doi.org/10.1007/s00216-021-03756-z

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/1aaf2c69-eb2a-4811-aa06-60e5166e2b63
https://research.rug.nl/en/publications/1aaf2c69-eb2a-4811-aa06-60e5166e2b63
https://doi.org/10.1007/s00216-021-03756-z
https://pure.rug.nl/ws/files/199779590/Bults2022_Article_AnalyticalAndPharmacologicalCo.pdf

المؤلفون: Van De Merbel, Nico C., Olaleye, Oladapo, Spanov, Baubek, Bischoff, Rainer

المصدر: Van De Merbel , N C , Olaleye , O , Spanov , B & Bischoff , R 2022 , ' Large molecule bioanalysis by LC-MS : Beyond simply quantifying ' , Bioanalysis , vol. 14 , no. 7 , pp. 397-400 . https://doi.org/10.4155/bio-2022-0032

مصطلحات موضوعية: Biomarkers, Biopharmaceuticals, Biotransformation, Heterogeneity, LC-MS, Proteins

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/8f284704-9e4d-45fc-811f-5e3569e3069a
https://research.rug.nl/en/publications/8f284704-9e4d-45fc-811f-5e3569e3069a
https://doi.org/10.4155/bio-2022-0032
https://pure.rug.nl/ws/files/258187317/bio_2022_0032.pdf
http://www.scopus.com/inward/record.url?scp=85127402304&partnerID=8YFLogxK

المؤلفون: Schalk, Frank B., Guerrieri, Davide, Poetzl, Johann, van de Merbel, Nico C.

المصدر: Bioanalysis ; page 1-12 ; ISSN 1757-6180 1757-6199

الاتاحة: https://doi.org/10.1080/17576180.2024.2441058
https://www.tandfonline.com/doi/pdf/10.1080/17576180.2024.2441058

المؤلفون: Walravens, Joeri, Sleumer, Bas, Vos, Michel J., Snaterse, Gido, Narinx, Nick, Antonio, Leen, Reyns, Tim, Fiers, Tom, Kema, Ido P., Kaufman, Jean, van de Merbel, Nico C., Lapauw, Bruno

المصدر: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ; ISSN: 0021-972X ; ISSN: 1945-7197

مصطلحات موضوعية: Medicine and Health Sciences, testosterone, SHBG, polymorphisms, LC-MS/MS, healthy men, free testosterone, HORMONE-BINDING GLOBULIN, ANDROGEN, PROTEINS

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/01J08WB5M6V81HPQJM38P48H2B; http://doi.org/10.1210/clinem/dgae280; https://biblio.ugent.be/publication/01J08WB5M6V81HPQJM38P48H2B/file/01J08WFEMYCNHKD56DX5PVMYN5

الاتاحة: https://biblio.ugent.be/publication/01J08WB5M6V81HPQJM38P48H2B
http://hdl.handle.net/1854/LU-01J08WB5M6V81HPQJM38P48H2B
https://doi.org/10.1210/clinem/dgae280
https://biblio.ugent.be/publication/01J08WB5M6V81HPQJM38P48H2B/file/01J08WFEMYCNHKD56DX5PVMYN5

المؤلفون: Olaleye, Oladapo, Govorukhina, Natalia, van de Merbel, Nico C., Bischoff, Rainer

Relation: https://zenodo.org/communities/eu; https://doi.org/10.3390/biom11121791; oai:zenodo.org:6778634

الاتاحة: https://doi.org/10.3390/biom11121791

المؤلفون: Olaleye, Oladapo, Spanov, Baubek, Ford, Robert, Govorukhina, Natalia, van de Merbel, Nico C., Bischoff, Rainer

Relation: https://zenodo.org/communities/eu; https://doi.org/10.1021/acs.analchem.1c02807; oai:zenodo.org:6778460

الاتاحة: https://doi.org/10.1021/acs.analchem.1c02807

المؤلفون: Spanov, Baubek, Govorukhina, Natalia, van de Merbel, Nico C., Bischoff, Rainer

Relation: https://zenodo.org/communities/eu; https://doi.org/10.1016/j.jcoa.2021.100025; oai:zenodo.org:6778614

الاتاحة: https://doi.org/10.1016/j.jcoa.2021.100025

المؤلفون: Bults, Peter, Spanov, Baubek, Olaleye, Oladapo, van de Merbel, Nico C., Bischoff, Rainer

Relation: https://zenodo.org/communities/eu; https://doi.org/10.1016/j.jchromb.2019.01.032; oai:zenodo.org:6777841

الاتاحة: https://doi.org/10.1016/j.jchromb.2019.01.032

المؤلفون: Klont, Frank, Pouwels, Simon D, Bults, Peter, van de Merbel, Nico C, Ten Hacken, Nick H T, Horvatovich, Péter, Bischoff, Rainer

المصدر: Klont , F , Pouwels , S D , Bults , P , van de Merbel , N C , Ten Hacken , N H T , Horvatovich , P & Bischoff , R 2019 , ' Quantification of surfactant protein D (SPD) in human serum by liquid chromatography-mass spectrometry (LC-MS) ' , Talanta , vol. 202 , pp. 507-513 . https://doi.org/10.1016/j.talanta.2019.05.028

مصطلحات موضوعية: Biomarker, COPD, Immunoaffinity enrichment, LC-MS, Methionine oxidation, Quantification, TARGETED PROTEOMICS, PEPTIDES, OPPORTUNITIES

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/677ac90e-ab4d-442e-897b-49b95ebe2d32
https://research.rug.nl/en/publications/677ac90e-ab4d-442e-897b-49b95ebe2d32
https://doi.org/10.1016/j.talanta.2019.05.028
https://pure.rug.nl/ws/files/84868117/1_s2.0_S0039914019305120_main.pdf

المؤلفون: van de Merbel, Nico C.

المصدر: van de Merbel , N C 2019 , ' Protein quantification by LC-MS : A decade of progress through the pages of Bioanalysis ' , Bioanalysis , vol. 11 , no. 7 , pp. 629-644 . https://doi.org/10.4155/bio-2019-0032

مصطلحات موضوعية: biomarkers, biopharmaceuticals, biotransformation, digestion, HRMS, immunocapture, isoforms, LC-MS, proteins, PEPTIDE IMMUNOAFFINITY ENRICHMENT, LARGE THERAPEUTIC PROTEINS, MS/MS QUANTIFICATION, LIGAND-BINDING, MONOCLONAL-ANTIBODY, BIOLOGICAL SAMPLES, QUANTITATIVE-DETERMINATION, ABSOLUTE QUANTITATION, ENZYMATIC DIGESTION, TRYPSIN DIGESTION

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/a8cfea52-25ee-434b-9830-1256a6169171
https://research.rug.nl/en/publications/a8cfea52-25ee-434b-9830-1256a6169171
https://doi.org/10.4155/bio-2019-0032
https://pure.rug.nl/ws/files/103511021/bio_2019_0032.pdf