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1Academic Journal
المؤلفون: de Graaf, IAM, de Kanter, R, de Jager, MH, Camacho, R, Langenkamp, E, van de Kerkhof, EG, Groothuis, GMM
المصدر: de Graaf , IAM , de Kanter , R , de Jager , MH , Camacho , R , Langenkamp , E , van de Kerkhof , EG & Groothuis , GMM 2006 , ' Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction ' , Drug Metabolism and Disposition , vol. 34 , no. 4 , pp. 591-599 . https://doi.org/10.1124/dmd.105.006726
مصطلحات موضوعية: DRUG METABOLIC-CLEARANCE, HUMAN LIVER SLICES, ISOLATED HEPATOCYTES, HEPATIC MICROSOMES, ENZYME-ACTIVITIES, PRIMARY CULTURES, SMALL-INTESTINE, BASIC DRUGS, PHASE-I, CYTOCHROME-P450
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/2d285aa6-84a6-4fe9-a9a7-97b1569fc08a
https://research.rug.nl/en/publications/2d285aa6-84a6-4fe9-a9a7-97b1569fc08a
https://doi.org/10.1124/dmd.105.006726
https://pure.rug.nl/ws/files/193112380/Empirical_validation_of_a_rat_in_vitro_organ_slice_model_as_a_tool_for_in_vivo.pdf -
2Academic Journal
المؤلفون: van de Kerkhof, EG, de Graaf, IAM, de Jager, MH, Meijer, DKF, Groothuis, GMM
المصدر: van de Kerkhof , EG , de Graaf , IAM , de Jager , MH , Meijer , DKF & Groothuis , GMM 2005 , ' Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies ' , Drug Metabolism and Disposition , vol. 33 , no. 11 , pp. 1613-1620 . https://doi.org/10.1124/dmd.105.005686
مصطلحات موضوعية: TESTOSTERONE-METABOLISM, CYTOCHROME-P450 ENZYMES, MUCOSAL CELLS, EVERTED SACS, LIVER, MICROSOMES, INVITRO, 7-ETHOXYCOUMARIN, TRANSFERASE, INHIBITION
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/d1680951-36bc-4777-868c-8aa70f77b64f
https://research.rug.nl/en/publications/d1680951-36bc-4777-868c-8aa70f77b64f
https://doi.org/10.1124/dmd.105.005686
https://pure.rug.nl/ws/files/196871358/Characterization_of_rat_small_intestinal_and_colon_precision_cut_slices_as_an_in_vitro.pdf