المؤلفون: Yu Zou (547570), Lulu Guan (11735738), Jingwang Tan (12530897), Bote Qi (12530900), Ying Wang (11406), Qingwen Zhang (294089), Yunxiang Sun (517700)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, intracellular fibrillary inclusions, interaction analyses show, including alzheimer ’, chronic traumatic encephalopathy, residue tyrosine 310, atom molecular dynamics, associated protein tau, 311 , 306 , underlying inhibitory mechanism, inhibited tau aggregation, inhibit tau aggregation, inhibitory mechanism, tyrosine phosphorylation, systematically investigated, sheet oligomers, sheet aggregates, rich aggregates, r3 plays, performing extensive, oligomerization dynamics, important role, hydrogen bonding

Relation: https://figshare.com/articles/journal_contribution/Atomistic_Insights_into_the_Inhibitory_Mechanism_of_Tyrosine_Phosphorylation_against_the_Aggregation_of_Human_Tau_Fragment_PHF6/21806067

الاتاحة: https://doi.org/10.1021/acs.jpcb.2c07568.s001

المؤلفون: Nan Zhang (46264), Chaoren Yan (7296704), Changji Yin (4340092), Xiaoling Hu (5499059), Ping Guan (515305), Yuan Cheng (72244)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, reduced solvent exposure, peptide chains within, multisite binding patterns, molecule drug candidate, mediating conformational rearrangement, induced remodeling mechanism, fibrillary aggregates cannot, experimental studies confirmed, abundant benzene ring, structural remodeling mechanism, random coil structure, egcg ), extracted, 17 , underlying inhibitory, therefore restarted, suspended due, structural features, small molecules, rich oligomers, protein structure, promising small

Relation: https://figshare.com/articles/journal_contribution/Structural_Remodeling_Mechanism_of_the_Toxic_Amyloid_Fibrillary_Mediated_by_Epigallocatechin-3-gallate/21717205

الاتاحة: https://doi.org/10.1021/acsomega.2c05995.s001