المؤلفون: Jan Elsner (1562344), Dan Cashion (4539784), Dale Robinson (4539790), Sogole Bahmanyar (1562314), Lida Tehrani (845395), Kimberly E. Fultz (1562359), Rama Krishna Narla (1562347), Xiaohui Peng (528779), Tam Tran (522680), Julius Apuy (1562326), Laurie LeBrun (845401), Katerina Leftheris (2459563), John F. Boylan (11355218), Dan Zhu (139675), Jennifer R. Riggs (1278165)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, strong antiproliferative activity, showed significant single, cyp inhibition profile, 9 nm ), tumor cell proliferation, ttk protein inhibitors, selective ttk inhibitors, guided optimization provides, 6 , 25 , tnbc xenograft model, 50 , 0 nm ), 0 nm, tumor types, ttk selectivity, ttk ic, optimization campaign, wide range, vivo efficacy, recently reported, many organisms

Relation: https://figshare.com/articles/journal_contribution/Structure-Guided_Optimization_Provides_a_Series_of_TTK_Protein_Inhibitors_with_Potent_Antitumor_Activity/16539698

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00635.s001

المؤلفون: Jan Elsner (1562344), Dan Cashion (4539784), Dale Robinson (4539790), Sogole Bahmanyar (1562314), Lida Tehrani (845395), Kimberly E. Fultz (1562359), Rama Krishna Narla (1562347), Xiaohui Peng (528779), Tam Tran (522680), Julius Apuy (1562326), Laurie LeBrun (845401), Katerina Leftheris (2459563), John F. Boylan (11355218), Dan Zhu (139675), Jennifer R. Riggs (1278165)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, strong antiproliferative activity, showed significant single, cyp inhibition profile, 9 nm ), tumor cell proliferation, ttk protein inhibitors, selective ttk inhibitors, guided optimization provides, 6 , 25 , tnbc xenograft model, 50 , 0 nm ), 0 nm, tumor types, ttk selectivity, ttk ic, optimization campaign, wide range, vivo efficacy, recently reported, many organisms

Relation: https://figshare.com/articles/dataset/Structure-Guided_Optimization_Provides_a_Series_of_TTK_Protein_Inhibitors_with_Potent_Antitumor_Activity/16539701

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00635.s002