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1Academic JournalCrystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase
المؤلفون: Huiying Li, Christine D. Hardy, Cory T. Reidl, Qing Jing, Fengtian Xue, Maris Cinelli, Richard B. Silverman, Thomas L. Poulos
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, nitric oxide synthase, undergo conformational changes, substantial dynamic differences, computational results show, second inhibitor molecule, tighter dimer interface, conserved tyrosine near, subtle structural differences, develop inhibitors selective, nos inhibitor binding, dimer interface, conserved tyrosine, selective inhibitors, structural basis, nos isoforms, changes conformation, selective dynamics, computational methods, computational insights, inhibitor binding
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2Academic JournalCrystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase
المؤلفون: Huiying Li, Christine D. Hardy, Cory T. Reidl, Qing Jing, Fengtian Xue, Maris Cinelli, Richard B. Silverman, Thomas L. Poulos
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, nitric oxide synthase, undergo conformational changes, substantial dynamic differences, computational results show, second inhibitor molecule, tighter dimer interface, conserved tyrosine near, subtle structural differences, develop inhibitors selective, nos inhibitor binding, dimer interface, conserved tyrosine, selective inhibitors, structural basis, nos isoforms, changes conformation, selective dynamics, computational methods, computational insights, inhibitor binding