المؤلفون: Masatsune Shibutani, Hideki Tanda, Hiroaki Kasashima, Tatsunari Fukuoka, Shinichiro Kashiwagi, Kiyoshi Maeda

المصدر: Scientific Reports, Vol 15, Iss 1, Pp 1-7 (2025)

مصطلحات موضوعية: Colorectal cancer, Trifluridine/thymidine phosphorylase inhibitor, Bevacizumab, Neutropenia, Renal function, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/b9cbed4524fb410aba9a6f847720986b

المؤلفون: Aknin, Karen, Bontemps, Alexis, Farce, Amaury, Merlet, E., Belmont, P., Helissey, P., Chavatte, Philippe, Sari, Marie-Agnès, Giorgi-Renault, S., Desbène-Finck, S.

المساهمون: Université de Lille, Inserm, CHU Lille, Cibles Thérapeutiques et conception de médicaments CiTCoM - UMR 8038, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques LCBPT - UMR 8601

مصطلحات موضوعية: Thymidine phosphorylase inhibitor, multicomponent reactions, molecular docking, pyrido[2, 3-d]pyrimidinedione, pyrimido[4, 5-b]quinoline-2, 4-dione

وصف الملف: application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf

Relation: Journal of Enzyme Inhibition and Medicinal Chemistry; J Enzyme Inhib Med Chem; http://hdl.handle.net/20.500.12210/100983

الاتاحة: https://hdl.handle.net/20.500.12210/100983

المؤلفون: Karen Aknin, Alexis Bontemps, Amaury Farce, Eric Merlet, Philippe Belmont, Philippe Helissey, Philippe Chavatte, Marie-Agnès Sari, Sylviane Giorgi-Renault, Stéphanie Desbène-Finck

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 252-268 (2022)

مصطلحات موضوعية: thymidine phosphorylase inhibitor, multicomponent reactions, molecular docking, pyrido[2,3-d]pyrimidinedione, pyrimido[4,5-b]quinoline-2,4-dione, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/1c7dc5e7c7d94f0b8e312f4d2f4c2263

المؤلفون: Eiji Oki, Akitaka Makiyama, Yuji Miyamoto, Masahito Kotaka, Hirofumi Kawanaka, Keisuke Miwa, Akira Kabashima, Tomohiro Noguchi, Kotaro Yuge, Tomomi Kashiwada, Koji Ando, Mototsugu Shimokawa, Hiroshi Saeki, Yoshito Akagi, Hideo Baba, Yoshihiko Maehara, Masaki Mori

المصدر: Cancer Medicine, Vol 10, Iss 2, Pp 454-461 (2021)

مصطلحات موضوعية: bevacizumab, colorectal cancer, elderly, thymidine phosphorylase inhibitor, Trifluridine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-7634

URL الوصول: https://doaj.org/article/13e4f89644bc4c1e85fd861d81c0eaa6

المؤلفون: Karen Aknin (11866749), Alexis Bontemps (1737199), Amaury Farce (655567), Eric Merlet (11866752), Philippe Belmont (1554853), Philippe Helissey (2440639), Philippe Chavatte (655568), Marie-Agnès Sari (112021), Sylviane Giorgi-Renault (2440645), Stéphanie Desbène-Finck (2440636)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Virology, Chemical Sciences not elsewhere classified, Thymidine phosphorylase inhibitor, multicomponent reactions, molecular docking, pyrido[2,3-d]pyrimidinedione, pyrimido[4,5-b]quinoline-2,4-dione

Relation: https://figshare.com/articles/journal_contribution/Polycyclic_nitrogen_heterocycles_as_potential_thymidine_phosphorylase_inhibitors_synthesis_biological_evaluation_and_molecular_docking_study/17371887

الاتاحة: https://doi.org/10.6084/m9.figshare.17371887.v1

المؤلفون: Nathalia D. de Moura Sperotto, Rodrigo Braccini Madeira Silva, Marcia Alberton Perelló, Ana Flávia Borsoi, Adilio da Silva Dadda, Candida Deves Roth, Raquel Dal Sasso Freitas, Ana Paula Duarte de Souza, Deise do Nascimento de Freitas, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Débora Dreher Nabinger, Stefani Altenhofen, Carla Denise Bonan, Valnês S. Rodrigues-Junior, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado

المصدر: Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111672- (2021)

مصطلحات موضوعية: Colorectal cancer, Tumor xenograft model, Pharmacokinetics, Thymidine phosphorylase inhibitor, Toxicity, Therapeutics. Pharmacology, RM1-950

Relation: http://www.sciencedirect.com/science/article/pii/S0753332221004546; https://doaj.org/toc/0753-3322; https://doaj.org/article/6974146b079f4acc9c3fe70b9fb77449

الاتاحة: https://doi.org/10.1016/j.biopha.2021.111672
https://doaj.org/article/6974146b079f4acc9c3fe70b9fb77449

المؤلفون: Aknin, Karen, Bontemps, Alexis, Farce, Amaury, Merlet, Eric, Belmont, Philippe, Helissey, Philippe, Chavatte, Philippe, Sari, Marie-Agnès, Giorgi-Renault, Sylviane, Desbène-Finck, Stéphanie

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 252-268 (2022)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

مصطلحات موضوعية: Thymidine Phosphorylase, Dose-Response Relationship, Drug, Molecular Structure, Cell Survival, Nitrogen, multicomponent reactions, molecular docking, RM1-950, Cell Line, pyrimido[4,5-b]quinoline-2,4-dione, Molecular Docking Simulation, thymidine phosphorylase inhibitor, Structure-Activity Relationship, pyrido[2,3-d]pyrimidinedione, Heterocyclic Compounds, Humans, Polycyclic Compounds, Therapeutics. Pharmacology, Enzyme Inhibitors, Research Article, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d61c4525f3baca97f535bcc1f70d025
https://doaj.org/article/1c7dc5e7c7d94f0b8e312f4d2f4c2263

المؤلفون: Hideki Kazuno, Norihiko Suzuki, Shingo Yano, Tomohiro Emura, Tsutomu Sato, Yukio Tada

المصدر: Chem-Bio Informatics Journal. 2017, 17:19

المؤلفون: Bijnsdorp, I. V., Capriotti, F., Kruyt, F. A. E., Losekoot, N., Fukushima, M., Griffioen, A. W., Thijssen, V. L., Peters, G. J.

المصدر: Bijnsdorp , I V , Capriotti , F , Kruyt , F A E , Losekoot , N , Fukushima , M , Griffioen , A W , Thijssen , V L & Peters , G J 2011 , ' Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors ' , British Jounal of Cancer , vol. 104 , no. 7 , pp. 1185-1192 . https://doi.org/10.1038/bjc.2011.74

مصطلحات موضوعية: thymidine phosphorylase, thymidine phosphorylase inhibitor, angiogenesis, deoxyribose, GROWTH FACTOR/THYMIDINE PHOSPHORYLASE, TUMOR-NECROSIS-FACTOR, DIHYDROPYRIMIDINE DEHYDROGENASE, FLUOROPYRIMIDINE SENSITIVITY, GASTRIC-CANCER, COLON-CANCER, EXPRESSION, 2-DEOXY-L-RIBOSE, INHIBITION, 2-DEOXY-D-RIBOSE

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/f3f21e3d-c7d6-4dd8-a195-e309d1b6354c

الاتاحة: https://hdl.handle.net/11370/f3f21e3d-c7d6-4dd8-a195-e309d1b6354c
https://research.rug.nl/en/publications/f3f21e3d-c7d6-4dd8-a195-e309d1b6354c
https://doi.org/10.1038/bjc.2011.74
https://pure.rug.nl/ws/files/62238653/Thymidine_phosphorylase_in_cancer_cells.pdf

المؤلفون: Bijnsdorp, I.V., Azijli, K., Jansen, E.E., Wamelink, M.M., Jakobs, C., Struys, E.A., Fukushima, M., Kruyt, F.A.E., Peters, G.J.

المساهمون: Department Medical Oncology, VU University Medical Center Amsterdam, Department of Clinical Chemistry, Tokushima research center, Department of Medical Oncology, University Medical Center Groningen Groningen (UMCG)

المصدر: ISSN: 0006-2952.

مصطلحات موضوعية: thymidine phosphorylase, angiogenesis, deoxyribose, thymidine phosphorylase inhibitor

Relation: hal-00608939; https://hal.archives-ouvertes.fr/hal-00608939; https://hal.archives-ouvertes.fr/hal-00608939/document; https://hal.archives-ouvertes.fr/hal-00608939/file/PEER_stage2_10.1016%252Fj.bcp.2010.05.009.pdf

الاتاحة: https://hal.archives-ouvertes.fr/hal-00608939
https://hal.archives-ouvertes.fr/hal-00608939/document
https://hal.archives-ouvertes.fr/hal-00608939/file/PEER_stage2_10.1016%252Fj.bcp.2010.05.009.pdf
https://doi.org/10.1016/j.bcp.2010.05.009

المؤلفون: de Bruin, M, van Capel, T, Van der Born, K, Kruyt, FA, Fukushinna, M, Hoekman, K, Pinedo, HM, Peters, G. J.

المصدر: de Bruin , M , van Capel , T , Van der Born , K , Kruyt , FA , Fukushinna , M , Hoekman , K , Pinedo , HM & Peters , G J 2003 , ' Role of platelet-derived enclothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity ' , British Jounal of Cancer , vol. 88 , no. 6 , pp. 957-964 . https://doi.org/10.1038/sj.bjc.6600808

مصطلحات موضوعية: thymidine phosphorylase, 5-fluorouracil, 5-deoxyfluorouridine, ftorafur, trifluorothymidine, thymidine phosphorylase inhibitor, PYRIMIDINE NUCLEOSIDE PHOSPHORYLASES, THYMIDINE-PHOSPHORYLASE, IN-VITRO, THYMIDYLATE SYNTHASE, COLORECTAL-CANCER, ANGIOGENIC FACTOR, EXPRESSION MEASUREMENT, URIDINE PHOSPHORYLASE, TUMOR ANGIOGENESIS, GASTRIC-CARCINOMA

وصف الملف: application/pdf

Relation: https://research.rug.nl/en/publications/a90a2e6a-6edd-43b4-bf43-6dce32466fee

الاتاحة: https://hdl.handle.net/11370/a90a2e6a-6edd-43b4-bf43-6dce32466fee
https://research.rug.nl/en/publications/a90a2e6a-6edd-43b4-bf43-6dce32466fee
https://doi.org/10.1038/sj.bjc.6600808
https://pure.rug.nl/ws/files/41917960/Role_of_platelet_derived_endothelial_cell_growth_factorthymidine_phosphorylase_in_fluoropyrimidine_sensitivity.pdf

المؤلفون: Akihiro Kojima, Hideyuki Yamamoto, Hiroshi Sunaga, Myungmi Oh, Norihiko Narita, Shigeharu Fujieda, Takechiyo Yamada, Tetsuji Takabayashi

المصدر: Allergology International. 2011, 60(1):79

المؤلفون: M. Suenaga, M. Schirripa, S. Cao, W. Zhang, D. Yang, V. Dadduzio, L. Salvatore, B. Borelli, F. Pietrantonio, Y. Ning, S. Okazaki, M. D. Berger, Y. Miyamoto, R. Gopez, A. Barzi, T. Yamaguchi, F. Loupakis, H. Lenz

المساهمون: M. Suenaga, M. Schirripa, S. Cao, W. Zhang, D. Yang, V. Dadduzio, L. Salvatore, B. Borelli, F. Pietrantonio, Y. Ning, S. Okazaki, M.D. Berger, Y. Miyamoto, R. Gopez, A. Barzi, T. Yamaguchi, F. Loupaki, H. Lenz

مصطلحات موضوعية: Metastatic colorectal cancer, TAS-102, Thymidine phosphorylase inhibitor, Transporter, Trifluridine, Antineoplastic Agent, California, Colorectal Neoplasm, Disease-Free Survival, Drug Combination, Equilibrative Nucleoside Transporter 1, Female, Gene Frequency, Genotype, Human, Italy, Japan, Male, Neoplasm Metastasi, Organic Cation Transport Protein, Organic Cation Transporter 2, Pharmacogenetic, Pharmacogenomic Testing, Phenotype, Predictive Value of Test, Retrospective Studie, Treatment Outcome, Uracil, Pharmacogenomic Variant, Polymorphism

Relation: info:eu-repo/semantics/altIdentifier/pmid/28992563; info:eu-repo/semantics/altIdentifier/wos/WOS:000414850400021; volume:86; firstpage:197; lastpage:206; numberofpages:10; journal:EUROPEAN JOURNAL OF CANCER; http://hdl.handle.net/2434/564008; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85030693408

الاتاحة: http://hdl.handle.net/2434/564008
https://doi.org/10.1016/j.ejca.2017.08.033

المؤلفون: Masakazu Fukushima, Godefridus J. Peters, Michiel de Bruin, Klaas Hoekman, Kees Smid, Toni Van Capel, Herbert M. Pinedo

المساهمون: VU University medical center, Medical Biology, AII - Infectious diseases, AII - Inflammatory diseases

المصدر: de Bruin, M, van Capel, T, Smid, K, Fukushima, M, Hoekman, K, Pinedo, H M & Peters, G J 2004, ' The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase. ', European Journal of Pharmacology, vol. 491, no. 2-3, pp. 93-9 . https://doi.org/10.1016/j.ejphar.2004.03.025
European Journal of Pharmacology, 491(2-3), 93-9. Elsevier
European journal of pharmacology, 491(2-3), 93-99. Elsevier

مصطلحات موضوعية: Thymidine phosphorylase activity, Biology, Gene Expression Regulation, Enzymologic, chemistry.chemical_compound, Trifluorothymidine, Cell Line, Tumor, 5′-Deoxyfluorouridine, parasitic diseases, Humans, Enzyme Inhibitors, Thymidine phosphorylase, Nucleotide salvage, Phosphorolysis, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Thymidine phosphorylase inhibitor, Fluorine, Molecular biology, Thymine, Pyrimidines, Enzyme, chemistry, Biochemistry, Cell culture, Thymidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133a7d9348b719ccc677d4d4438c06fa
https://doi.org/10.1016/j.ejphar.2004.03.025

المصدر: Cancer Research. 59(8):1911-1916

مصطلحات موضوعية: thymidine phosphorylase inhibitor, angiogenesis, platelet-derived endothelial cell growth factor, parasitic diseases, apoptosis, thymidine phosphorylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f4dc6a317f86968d971ef8dc2ce0c8e
http://hdl.handle.net/10232/12200

المؤلفون: Sun, L., Li, J., Bera, H., Dolzhenko, A.V., Chiu, G.N.C., Chui, W.K.

المساهمون: PHARMACY

المصدر: Scopus

مصطلحات موضوعية: 5-Chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines, Fragment-based drug design, Mixed-type enzyme inhibition kinetics, Thymidine phosphorylase inhibitor

Relation: Sun, L., Li, J., Bera, H., Dolzhenko, A.V., Chiu, G.N.C., Chui, W.K. (2013). Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1, 5-a][1,3,5]triazines as thymidine phosphorylase inhibitors. European Journal of Medicinal Chemistry 70 : 400-410. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejmech.2013.10.022; http://scholarbank.nus.edu.sg/handle/10635/105967; 000330554400036

الاتاحة: http://scholarbank.nus.edu.sg/handle/10635/105967

المؤلفون: Tufan, Ahmet Çevik, Satıroğlu-Tufan, Naciye Lale

مصطلحات موضوعية: mitogen activated protein kinase p38, cell migration, kininogen, 1,4 phenylenebis(methylene)selenocyanate, suramin derivative, capillary, angiopoietin receptor, squalamine, cytokine, endothelium cell, cell adhesion molecule antagonist, transforming growth factor beta, Neovascularization, Pathologic, basic fibroblast growth factor antibody, steroid, cortisone, protein function, spironolactone, retinoid, fenretinide, purine derivative, carbohydrate derivative, protamine, anthracycline derivative, doxorubicin, saquinavir, in vivo study, ornithine decarboxylase inhibitor, transforming growth factor alpha, nitric oxide, thalidomide, metastasis, Humans, fibroblast growth factor 2, indole derivative, gm 1474, standardization, prothrombin, vasculotropin, goniodomin A, indinavir, scoring system, homocysteine, arylsulfatase inhibitor, assay, stromelysin, protein family, cyclosporin, cell proliferation, monoclonal antibody, validation process, ruthenium red derivative, platelet derived growth factor, kininostat, alpha cyclodextrin, scatter factor, amiloride, endostatin, protein tyrosine kinase inhibitor, Drug Evaluation, Preclinical, vasculotropin antibody, Angiogenesis Inhibitors, Chick Embryo, heparin, apomorphine, matrix metalloproteinase inhibitor, protamine sulfate, kininogen derivative, Chorioallantoic Membrane, angiogenesis, metastatin, Neoplasms, cell growth, vasculotropin receptor 2, motuporanine, bleomycin, tamoxifen, morphometrics, angiogenin antibody, apoptosis, thrombocyte factor 4, unclassified drug, hyaluronic acid binding protein, tumor growth, heparan sulfate, titanocene dichloride, cancer invasion, alpha thymosin peptide, vasculotropin diphtheria toxin conjugate, review, somatostatin, somatostatin derivative, interleukin 2, Models, Biological, angiotensinogen derivative, peptide derivative, chorioallantois, organ culture, pentosan polysulfate, microsomal aminopeptidase inhibitor, tumor vascularization, fibroblast growth factor, mesoderm, sulindac, drug mechanism, Animals, Neoplasm Invasiveness, cell viability, suramin, cell culture, angiostatin, model, nonhuman, DNA synthesis, proteasome inhibitor, cost effectiveness analysis, embryo development, acetylsalicylic acid, fetus membrane, u 995, thymidine phosphorylase inhibitor, angiogenesis inhibitor, angiotensinogen, beta cyclodextrin, heparanase inhibitor, chemokinesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3566::0c1e536e221d12826b693412fc6cd476
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4858

المؤلفون: HRIDAY BERA

المساهمون: PHARMACY, CHUI WAI KEUNG

مصطلحات موضوعية: 1,3,5-triazine, thymidine phosphorylase inhibitor, 3D-QSAR, mixed type inhibition, breast cancer, anti-angiogenesis

Relation: HRIDAY BERA (2012-01-20). SYNTHESIS AND BIOLOGICAL EVALUATION OF THE DERIVATIVES OF 1,3,5-TRIAZIN-2,4-DIONES AND THEIR FUSED ANALOGUES. ScholarBank@NUS Repository.; http://scholarbank.nus.edu.sg/handle/10635/33403; NOT_IN_WOS

الاتاحة: http://scholarbank.nus.edu.sg/handle/10635/33403

المؤلفون: 松下, 茂人, マツシタ, シゲト, Matsushita, Shigeto

مصطلحات موضوعية: thymidine phosphorylase, thymidine phosphorylase inhibitor, angiogenesis, apoptosis, platelet-derived endothelial cell growth factor

Time: 493

وصف الملف: application/pdf

Relation: http://id.ndl.go.jp/bib/000000339357; http://dl.ndl.go.jp/info:ndljp/pid/3154165; Cancer Research; 59; 1911; 1916; AA00598557; https://ir.kagoshima-u.ac.jp/record/10758/files/000000339357.pdf

الاتاحة: https://ir.kagoshima-u.ac.jp/record/10758/files/000000339357.pdf