المؤلفون: Guerrero Vargas, Jacky Michelle

المساهمون: Alméciga Diaz, Carlos Javier

مصطلحات موضوعية: Enfermedad de Tay-Sachs, Terapia génica, CRISPR/nCas9, Vectores no virales, β hexosaminidasa A, Polímero PP6D5, Tay-Sachs disease, Gene therapy, Non-viral vectors, β hexosaminidase A, PP6D5 polymer, Maestría en ciencias biológicas - Tesis y disertaciones académicas, Terapia de gen, Proteína 9 Asociada a CRISPR

Time: 2022-2024

وصف الملف: PDF; application/pdf

Relation: http://hdl.handle.net/10554/68334; instname:Pontificia Universidad Javeriana; reponame:Repositorio Institucional - Pontificia Universidad Javeriana; repourl:https://repository.javeriana.edu.co

الاتاحة: http://hdl.handle.net/10554/68334

المؤلفون: Lemaitre Gómez, Paloma

المساهمون: Alméciga Díaz, Carlos Javier, Leal Bohorquez, Andrés Felipe, Rodríguez Arias, Edwin Alexander

مصطلحات موضوعية: Mucopolisacaridosis IIIB, CRISPR/nCas9, Terapia génica, Edición genómica, CRISPR/Cas9, Mucopolysaccharidosis IIIB, Gene therapy, Genome editing, Microbiología industrial - Tesis y disertaciones académicas, Terapia de gen - Bogotá (Colombia), Mucopolisacaridosis, Genómica

جغرافية الموضوع: Colombia, Bogotá (Colombia)

Time: 2021-2022

وصف الملف: PDF; application/pdf

Relation: http://hdl.handle.net/10554/60402; instname:Pontificia Universidad Javeriana; reponame:Repositorio Institucional - Pontificia Universidad Javeriana; repourl:https://repository.javeriana.edu.co

الاتاحة: http://hdl.handle.net/10554/60402

المؤلفون: Olivo Yepez, Alvaro

المساهمون: Linares Márquez, Pascual

المصدر: Universidad Veracruzana
UV
Repositorio Institucional de la UV

مصطلحات موضوعية: Responsabilidad, Bioética, Terapia de gen

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::506920ae077f62c44974b008cc4b6a69
http://cdigital.uv.mx/handle/1944/50308

المؤلفون: Ortiz, Raúl, Prados, José, Melguizo, Consolación, Arias, José L, Ruiz, M Adolfina, Alvarez, Pablo J, Caba, Octavio, Luque, Raquel, Segura, Ana, Aránega, Antonia

المساهمون: Ortiz,R, Prados,J, Melguizo,C, Alvarez,PJ, Caba,O, Aránega,A Institute of Biopathology and Regenerative Medicine (IBIMER). Arias,JL, Ruiz, MA Department of Pharmacy and Pharmaceutical Technology, University of Granada, Granada, Spain. Caba,O Department of Health Science, University of Jaén, Jaén, Spain. Luque,R Service of Medical Oncology, Virgen de las Nieves Hospital, Granada, Spain. Segura,A CSIC-Estacion Experimental del Zaidin, Department of Environmental Protection, Granada, Spain., This study was supported by the Department of Health of the Autonomous Government of Andalusia, Spain (project nos PI-0338 and PE-2008-FQM-3993).

مصطلحات موضوعية: colon cancer, combined therapy, 5-fluorouracil, gene therapy, E gene, poly (ε-caprolactone), Neoplasias del Colon, Terapia de Gen, Humanos, Fluorouracilo, Nanopartículas, Antineoplásicos, Apoptosis, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Colonic Neoplasms, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Gene Therapy, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidinones::Uracil::Fluorouracil, Medical Subject Headings::Technology, Industry, Agriculture::Technology, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents

وصف الملف: application/pdf

Relation: http://www.dovepress.com/5-fluorouracil-loaded-polyepsilon-caprolactone-nanoparticles-combined--peer-reviewed-article-IJN; Ortiz R, Prados J, Melguizo C, Arias JL, Ruiz MA, Álvarez PJ, et al. 5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer. Int J Nanomedicine. 2012;7:95-107; http://hdl.handle.net/10668/569; PMC3260954

الاتاحة: http://hdl.handle.net/10668/569
https://doi.org/10.2147/IJN.S26401

المؤلفون: Bittar Yepes, Amaury Fernando

المساهمون: Bloch Morel, Natasha Ivonne, Reyes Barrios, Luis Humberto, Bernal Giraldo, Adriana Jimena

مصطلحات موضوعية: Terapia de gen, Enfermedad de Parkinson, Plásmidos, Microbiología

وصف الملف: 26 hojas; application/pdf

Relation: http://hdl.handle.net/1992/51326; 23490.pdf; instname:Universidad de los Andes; reponame:Repositorio Institucional Séneca; repourl:https://repositorio.uniandes.edu.co/

الاتاحة: http://hdl.handle.net/1992/51326

المؤلفون: Herrera Mejía, María Juliana

المساهمون: Alméciga-Díaz, Carlos Javier

مصطلحات موضوعية: Mucopolisacaridosis IV, Terapia de gen, Microbiología industrial - Tesis y disertaciones académicas

وصف الملف: PDF; application/pdf

Relation: http://hdl.handle.net/10554/11812; instname:Pontificia Universidad Javeriana; reponame:Repositorio Institucional - Pontificia Universidad Javeriana; repourl:https://repository.javeriana.edu.co

الاتاحة: http://hdl.handle.net/10554/11812

المؤلفون: Salamanca Valero, David Julián

المساهمون: Moreno Durán, Carmen Helena

مصطلحات موضوعية: Terapia génica, HLA, Adenovirus recombinante, Métodos de inmunoterapia, Licenciatura en Biología - Tesis y disertaciones académicas, Cáncer - Tratamiento - Terapia de gen, Inmunoterapia, Inmunología, Gene therapy, Recombinant adenovirus, Immunotherapy methods

وصف الملف: pdf; application/pdf

Relation: http://hdl.handle.net/11349/26250

الاتاحة: http://hdl.handle.net/11349/26250

المؤلفون: Sánchez Daza, Anamaría Constanza

Thesis Advisors: Asenjo de Leuze, Juan, Andrews Farrow, Barbara, Caviedes Fernández, Pablo, Gerdtzen Hakim, Ziomara, Salazar Aguirre, Oriana

مصطلحات موضوعية: Alcoholismo, Terapia de gen, Genoma humano, Terapia génica

الاتاحة: http://repositorio.uchile.cl/handle/2250/147444

المؤلفون: Arango Saavedra, Mariana

المساهمون: Lattig Matiz, María Claudia, Garavito Aguilar, Zayra Viviana, Velásquez Toledo, María Marcela

المصدر: instname:Universidad de los Andes ; reponame:Repositorio Institucional Séneca

مصطلحات موضوعية: Terapia de gen - Investigaciones - Colombia, Enfermedades genéticas - Tratamiento - Investigaciones - Colombia, Adenovirus - Investigaciones, Microbiología

وصف الملف: 42 hojas; application/pdf

Relation: http://hdl.handle.net/1992/18946; u728415.pdf; instname:Universidad de los Andes; reponame:Repositorio Institucional Séneca; repourl:https://repositorio.uniandes.edu.co/

الاتاحة: http://hdl.handle.net/1992/18946

المؤلفون: Lucero Baeza, Alicia Trinidad

Thesis Advisors: Asenjo de Leuze, Juan, Andrews Farrow, Bárbara, Caviedes Fernández, Pablo, Salazar Aguirre, Oriana, Gerdtzen Hakim, Ziomara

مصطلحات موضوعية: Alcoholismo, Genoma humano, Terapia de gen, Terapia génica

الاتاحة: http://repositorio.uchile.cl/handle/2250/143630

المؤلفون: Veloso Chacón, Felipe

المساهمون: Holes, David S.

مصطلحات موضوعية: Investigaciones genéticas, Biología Computacional, Chile, Terapia de gen

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2990::31d1249217ad94028fbe3ac0499bf158
http://repositorio.unab.cl/xmlui/handle/ria/16971

المؤلفون: Barrera, Luis Alejandro, Gutiérrez, Mónica A., García Vallejo, Felipe, Tomatsu, Shunji, Cerón, Flavio, Alméciga Díaz, Carlos J., Domínguez, Martha C.

المصدر: Biomedica; Vol. 28 No. 3 (2008); 448-459 ; Biomédica; Vol. 28 Núm. 3 (2008); 448-459 ; 2590-7379 ; 0120-4157

مصطلحات موضوعية: mucopolisacaridosis IV A [genética], dependovirus, terapia de gen, técnicas de transferencia de gen, cultivo de virus, técnicas de cultivo, Mucopolysaccharidosis IV [genetics], gene therapy, gene transfer techniques, virus cultivation, culture techniques

وصف الملف: application/pdf

Relation: https://revistabiomedica.org/index.php/biomedica/article/view/85/83; Neufeld E, Muenzer J. The mucopolysaccharidosis. En: Scriver C, Beaudet A, Sly W, Valle D, editores. The metabolic and molecular bases of inherited diseases. New York: McGraw-Hill; 2001. p. 3421-52. 2. Montaño AM, Tomatsu S, Gottesman G, Smith M, Orii T. International Morquio A registry: Clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis. 2007;30:165-74. 3. Tomatsu S, Montaño A, Nishioka T, Gutiérrez M, Peña O, Trandafirescu G, et al. Mutation and polymorphism spectrum of the GALNS gene in mucopolysaccharidosis IVA (Morquio A). Hum Mutat. 2005;26:500-12. 4. Northover H, Cowie RA, Wraith JE. Mucopoly-saccharidosis type IVA (Morquio syndrome): a clinical review. J Inherit Metab Dis. 1996;19:357-65. 5. Cheng SH, Smith AE. Gene therapy progress and prospects: gene therapy of lysosomal storage disorders. Gene Ther. 2003;10:1275-81. 6. Tomatsu S, Fukuda M, Masue K, Sukegawa T, Fukao A, Yamagishi T, et al. Morquio disease: isolation, characterization and expression of full-length cDNA for human N-acetylgalactosamine-6-sulfate sulfatase. Biochem Biophys Res Commun. 1991;181:677-83. 7. Cooper D, Ball E, Stenson P, Phillips A, Howells K, Mort M. The Human Gene Mutation Data Base at the Institute of Medical Genetics in Cardiff. Consultado: los autores deben colocar la fecha de consulta. Disponible en: http://www.hgmd.cf.ac.uk. 8. Kato Z, Fukuda S, Tomatsu S, Vega H, Yasunaga T, Yamahishi A, et al. A Novel Common Missense Mutation G301C in the N-Acetylgalactosamine-6-sulfate Sulfatase Gene in Mucopolysaccharidosis IVA. Hum Genet. 1997;101:97-101. 9. Bernal J, Briceño I. Genetic and other diseases in the pottery of Tumaco-La Tolita culture in Colombia-Ecuador. Clin Genet. 2006;70:188-91. 10. Herzog RW, Hagstrom JN, Kung SH, Tai SJ, Wilson JM, Fisher KJ, et al. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus. Proc Natl Acad Sci U S A. 1997;94:5804-9. 11. Snyder RO, Miao CH, Patijn GA, Spratt SK, Danos O, Nagy D, et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet. 1997;16:270-6. 12. Rutledge EA, Russell DW. Adeno-associated virus vector integration junctions. J Virol. 1997;71:8429-36. 13. Xiao W, Berta SC, Lu MM, Moscioni AD, Tazelaar J, Wilson JM. Adeno-associated virus as a vector for liver-directed gene therapy. J Virol. 1998;72:10222-6. 14. Xiao X, Li J, Samulski R. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol. 1998;72:2224-32. 15. Fisher KJ, Kelley WM, Burda JF, Wilson JM. A novel adenovirus-adeno-associated virus hybrid vector that displays efficient rescue and delivery of the AAV genome. Hum Gene Ther. 1996;7:2079-87. 16. Vincent KA, Piraino ST, Wadsworth SC. Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products. J Virol. 1997;71:1897-905. 17. Samulski RJ, Chang LS, Shenk T. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression. J Virol. 1989;63:3822-8. 18. Sands M, Davidson B. Gene therapy for lysosomal storage diseases. Mol Ther. 2006;13:839-49. 19. Daly TM, Vogler C, Levy B, Haskins ME, Sands MS. Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease. Proc Natl Acad Sci USA. 1999;96:2296-300. 20. McEachern K, Nietupski J, Chuang W, Armentano D, Johnson J, Hutto E, et al. AAV8-mediated expression of glucocerebrosidase ameliorates the storage pathology in the visceral organs of a mouse model of Gaucher disease. J Gene Med. 2006;8:719-29. 21. Daly TM, Ohlemiller KK, Roberts MS, Vogler CA, Sands MS. Prevention of systemic clinical disease in MPS VII mice following AAV-mediated neonatal gene transfer. Gene Ther. 2001;8:1291-8. 22. Fraites TJ Jr, Schleissing MR, Shanely RA, Walter GA, Cloutier DA, Zolotukhin I, et al. Correction of the enzymatic and functional deficits in a model of Pompe disease using adeno-associated virus vectors. Mol Ther. 2002;5:571-8. 23. Park J, Murray GJ, Limaye A, Quirk JM, Gelderman MP, Brady RO, et al. Long-term correction of globotriaosylceramide storage in Fabry mice by recombinant adeno-associated virus-mediated gene transfer. Proc Natl Acad Sci USA. 2003;100:3450-4. 24. Hennig AK, Ogilvie JM, Ohlemiller KK, Timmers AM, Hauswirth WW, Sands MS. AAV-mediated intravitreal gene therapy reduces lysosomal storage in the retinal pigmented epithelium and improves retinal function in adult MPS VII mice. Mol Ther. 2004;10:106-116. 25. Daly TM, Okuyama T, Vogler C, Haskins ME, Muzyczka N, Sands MS. Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology inmucopolysa-ccharidosis type VII mice. Hum Gene Ther. 1999;10: 85-94. 26. Ponder K, Haskins M. Gene therapy for muco- polysaccharidosis. Expert Opin Biol Ther. 2007;7: 1333-45. 27. Miwa K, Matsui K, Terabe M, Ito K, Ishida M, Takagi H, et al. Construction of novel shuttle vectors and a cosmid vector for the glutamic acid-producing bacteria Brevibacterium lactofermentum and Corynebacterium glutamicum. Gene. 1985;39:281-6. 28. Grimm D, Kern A, Pawlita M, Ferrari F, Samulski R, Kleinschmidtl J. Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2. Gene Ther. 1999; 6: 1322-30. 29. Russell DW, Alexander IE, Miller AD. DNA synthesis and topoisomerase inhibitors increase transduction by adeno-associated virus vectors. Proc Natl Acad Sci USA. 1995;92:5719-23. 30. vanDiggelen O, Zhao H, Kleijer W, Janse H, Poorthuis B, Pelt JV, et al. A fluorometric enzyme assay for the diagnosis of Morquio type A. Clin Chem Acta. 1990;187:131-40. 31. Barrera L, Gutierrez M, Ceron F, Garcia L. Evaluation of an episomal expression construct containing the cDNA of iduronate sulfatase in (IDS) in fibroblasts from a patient with hunter syndrome. J Inherit Metab Dis. 2002;25(Suppl.1):160. 32. Zolotukhin S. Production of recombinant adeno-associated virus vectors. Hum Gene Ther. 2005; 16: 551-7. 33. Zolotukhin S, Byrne B, Mason E, Zolotukhin I, Potter M, Chesnut K, et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther. 1999;6:973-85. 34. Aucoin MG, Perrier M, Kamen AA. Critical assessment of current adeno-associated viral vector production and quantification methods. Biotechnol Adv. 2008;26:73-88. 35. Okoyama H, Chen C. Calcium phosphate mediated gene transfer into established cell lines. En: Murray EJ, editor. Methods in molecular biology: Gene transfer and expression protocols. Clifton: The Humana Press; 1991. p. 15-20. 36. Lu Y. Recombinant adeno-associated virus as delivery vector for gene therapy-a review. Stem Cells Dev. 2004;13:133-45. 37. Ward P, Clément N, Linden M. cis effects in adeno-associated virus type 2 replication. J Virol. 2007;81: 9976-89. 38. Summerford C, Samulski RJ. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol. 1998;72:1438-45. 39. Wu Z, Asokan A, Samulski R. Adeno-associated virus srotypes: vector toolkit for human gene therapy. Mol Ther. 2006;14:316-27. 40. Toietta G, Severini G, Traversari C, Tomatsu S, Sukegawa K, Fukuda S, et al. Various cells retrovirally transduced with N-acetylgalactosoamine-6-sulfate sulfatase correct Morquio skin fibroblasts in vitro. Hum Gene Ther. 2001;12:2007-16. 41. Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med. 2003;348:255-6. 42. Lewinski MK, Bushman FD. Retroviral DNA integration-mechanism and consequences. Adv Genet. 2005;55:147-81. 43. Landgrebe J, Dierks T, Schamidt B, Figura Kv. The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes. Gene. 2003;316:47-56. 44. Cosma M, Pepe P, Annunziata I, Newbold R, Grompe M, Parenti G, et al. The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell. 2003;113:445-56.; https://revistabiomedica.org/index.php/biomedica/article/view/85

الاتاحة: https://revistabiomedica.org/index.php/biomedica/article/view/85

المؤلفون: Méndez Ortega, María Catalina

المصدر: Séneca: repositorio Uniandes
Universidad de los Andes
instacron:Universidad de los Andes

مصطلحات موضوعية: Terapia antirretroviral altamente activa - Investigaciones, Biología, VIH - Investigaciones, Terapia de gen - Investigaciones, Interferencia de ARN - Investigaciones

وصف الملف: 70 hojas; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::03ad2b6deba9cc8ed24105c55d541162

المؤلفون: Gutiérrez, Mónica A, García-Vallejo, Felipe, Tomatsu, Shunji, Cerón, Flavio, Alméciga-Díaz, Carlos J, Domínguez, Martha C, Barrera, Luis A

المصدر: Biomédica, Volume: 28, Issue: 3, Pages: 448-450, Published: SEP 2008

مصطلحات موضوعية: virus cultivation, mucopolisacaridosis IV A, terapia de gen, técnicas de transferencia de gen, cultivo de virus, técnicas de cultivo, Mucopolysaccharidosis IV, gene transfer techniques, culture techniques, gene therapy, dependovirus

وصف الملف: text/html

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______618::7ed7e444d04ed9684b607a74d17d71a6
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-41572008000300015&lng=en&tlng=en

المؤلفون: Ocaranza Osses, Paula

Thesis Advisors: Israel Jacard, Yedy, Facultad de Ciencias Químicas y Farmacéuticas, Departamento de Química Farmacológica y Toxicológica

مصطلحات موضوعية: Doctorado en Bioquímica, Alcoholismo, Terapia de gen, Aldehído deshidrogenasa

الاتاحة: http://repositorio.uchile.cl/handle/2250/105230