المؤلفون: Shiwei Liu, Fukang Yuan, Hui Dong, Jiaqi Zhang, Xinyu Mao, Yangsui Liu, Huansong Li

المصدر: Biology Direct, Vol 19, Iss 1, Pp 1-17 (2024)

مصطلحات موضوعية: PTGES3, Peptide proteolysis-targeting chimera, Liposome, Hepatocellular Carcinoma, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1745-6150

URL الوصول: https://doaj.org/article/9cfe5a839eb84c7ea8f53f5bc47a387d

المؤلفون: Minseo YU, Ra Eun KIM, Yurim JEONG, Hyewon JANG, Se Been KIM, Jung-Yeon LIM

المصدر: Korean Journal of Clinical Laboratory Science, Vol 56, Iss 3, Pp 198-206 (2024)

مصطلحات موضوعية: apoptosis, burkitt’s lymphoma, enhancer of zeste homolog 2 protein, mettl3 protein, proteolysis targeting chimera, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2024.56.3.198; https://doaj.org/toc/1738-3544

URL الوصول: https://doaj.org/article/895f40d17ec04b28897d1c8e64b227bb

المؤلفون: Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng

المصدر: Frontiers in Drug Discovery, Vol 5 (2025)

مصطلحات موضوعية: protein-protein interaction (PPI), proteolysis targeting chimera (PROTAC), non-enzymatic protein targeting agents, targeted protein degradation (TPD), DNA damage repair (DDR), P53/MDM2 pathway, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fddsv.2025.1520734/full; https://doaj.org/toc/2674-0338

URL الوصول: https://doaj.org/article/1200de3939b04a4e915dbd777c7473c2

المؤلفون: Xiaowei Huang, Fengbo Wu, Jing Ye, Lian Wang, Xiaoyun Wang, Xiang Li, Gu He

المصدر: Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2402-2427 (2024)

مصطلحات موضوعية: Targeted protein degradation, Proteolysis targeting chimera, Endocytosis, Autophagy, Proximity-inducing modality, Post-translational modification, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524000133; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/dadeb76a64ec4253b040e28101ee915d

المؤلفون: Wang, Yuxin, Morisseau, Christophe, Takamura, Akihiro, Wan, Debin, Li, Dongyang, Sidoli, Simone, Yang, Jun, Wolan, Dennis W, Hammock, Bruce D, Kitamura, Seiya

المصدر: ACS Chemical Biology. 18(4)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Biotechnology, 2.1 Biological and endogenous factors, Cytosol, Epoxide Hydrolases, Proteolysis Targeting Chimera, Endoplasmic Reticulum Stress, Organic Chemistry, Biological sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8zx7s4f6
https://escholarship.org/content/qt8zx7s4f6/qt8zx7s4f6.pdf

المؤلفون: Pance, Katarina, Gramespacher, Josef A, Byrnes, James R, Salangsang, Fernando, Serrano, Juan-Antonio C, Cotton, Adam D, Steri, Veronica, Wells, James A

المصدر: Nature biotechnology. 41(2)

مصطلحات موضوعية: Cell Membrane, Receptors, Cytokine, Interleukin-2, Signal Transduction, Chemokine CXCL12, Proteolysis, Proteolysis Targeting Chimera, Biotechnology, Generic health relevance

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1bd0b1dm
https://escholarship.org/content/qt1bd0b1dm/qt1bd0b1dm.pdf

المؤلفون: Tran, Nathan L, Leconte, Georges A, Ferguson, Fleur M

المصدر: Current Protocols. 2(12)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Biotechnology, Genetics, Proteolysis, Proteins, compound optimization, medicinal chemistry, PROTAC, proteolysis-targeting chimera, targeted protein degradation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4bz2v5qh
https://escholarship.org/content/qt4bz2v5qh/qt4bz2v5qh.pdf

المؤلفون: Linyao Fan, Yingqiu Qi, Xi Yang, Yarui Xu, Yana Zhang, Longdi Wang, Anying Zhu, Lirong Zhang, Jian Song, Shengnan Du, Guangjun Nie, Huan Min

المصدر: Asian Journal of Pharmaceutical Sciences, Vol 19, Iss 4, Pp 100941- (2024)

مصطلحات موضوعية: LRG1, Renal fibrosis, Proteolysis targeting chimera, Targeting peptide, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1818087624000588; https://doaj.org/toc/1818-0876

URL الوصول: https://doaj.org/article/7c5d685097444fa1801f287319c7903f

المؤلفون: Yulu Zhang, Annan Ming, Junyan Wang, Wenmin Chen, Zhiqing Fang

المصدر: Pharmacological Research, Vol 205, Iss , Pp 107234- (2024)

مصطلحات موضوعية: Proteolysis targeting chimera (PROTAC), Castration-resistant prostate cancer (CRPC), Androgen receptor (AR), Cancer therapy, Drug target, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824001798; https://doaj.org/toc/1096-1186

URL الوصول: https://doaj.org/article/364ce6bf959a46618f61dcba2c1d960b

المؤلفون: André T. S. Vicente, Jorge A. R. Salvador

المصدر: MedComm, Vol 5, Iss 6, Pp n/a-n/a (2024)

مصطلحات موضوعية: bifunctional molecule, degrader, hematological malignancy, leukemia, PROteolysis‐TArgeting Chimera (PROTAC), targeted protein degradation, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2688-2663

URL الوصول: https://doaj.org/article/bf8c0c69d4d841d6a744bc6d0947a707

المؤلفون: Katharina Hilbig, Russell Towers, Marc Schmitz, Martin Bornhäuser, Petra Lennig, Yixin Zhang

المصدر: Molecules, Vol 29, Iss 12, p 2779 (2024)

مصطلحات موضوعية: cyclophilin A (CypA), cyclosporin A (CsA), protein degradation, protein–protein interactions, proteolysis targeting chimera (PROTAC), Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/12/2779; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/2280eb9fe3dd431299ddbb6b6607044b

المؤلفون: Patricia Muschong, Khader Awwad, Edward Price, Mario Mezler, Manuel Weinheimer

المصدر: Pharmaceutics, Vol 16, Iss 7, p 846 (2024)

مصطلحات موضوعية: Caco-2, beyond rule of five (bRo5), proteolysis targeting chimera (PROTAC), absorption, permeability, in vitro assay, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4923/16/7/846; https://doaj.org/toc/1999-4923

URL الوصول: https://doaj.org/article/a94c5963141f476788baf6d1cae2be35

المؤلفون: Deborah Grifagni, Elena Lenci, Alessia De Santis, Andrea Orsetti, Carlo Giorgio Barracchia, Filomena Tedesco, Raffaele Bellini Puglielli, Francesca Lucarelli, Angela Lauriola, Michael Assfalg, Francesca Cantini, Vito Calderone, Daniele Guardavaccaro, Andrea Trabocchi, Mariapina D’Onofrio, Simone Ciofi-Baffoni

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Immunology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, reversible covalent bond, proteolysis targeting chimera, crystallographic data complemented, cellular studies showed, pro , peptidomimetic molecule able, 3 ‑ chymotrypsin, cov ‑ 2, 2 3, peptidomimetic protacs, protac molecule, sulfur atom, study paves, pomalidomide moiety, pomalidomide cereblon, like protease, high degree, future applicability

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_GC-376_Based_Peptidomimetic_PROTAC_as_a_Degrader_of_3_Chymotrypsin-like_Protease_of_SARS-CoV_2/24975448

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00498.s001
https://figshare.com/articles/journal_contribution/Development_of_a_GC-376_Based_Peptidomimetic_PROTAC_as_a_Degrader_of_3_Chymotrypsin-like_Protease_of_SARS-CoV_2/24975448

المؤلفون: Mengdie Hu, Xiaomei Li, Lin Wang, Yanping Zhang, Yujie Sun, Hui Hua, Huina Liu, Ting Cai, Dongsheng Zhu, Qiuping Xiang

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Cancer, Chemical Sciences not elsewhere classified, ubiquitin – proteasome, proteolysis targeting chimera, attractive therapeutic strategy, attractive intervention strategy, dependent lipid peroxidation, significantly degraded gpx4, 5i , thereby inducing ferroptosis, gpx4 inducing ferroptosis, inducing ferroptosis, dependent manner, ferroptosis presents, study provides, related diseases, prostate cancer, novel form, molecule degrader, human diseases, ht1080 cells, efforts led, degraders using, cancer cells, breast cancer, biological evaluation

Relation: https://figshare.com/articles/journal_contribution/ZX703_A_Small-Molecule_Degrader_of_GPX4_Inducing_Ferroptosis_in_Human_Cancer_Cells/25225797

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00571.s001
https://figshare.com/articles/journal_contribution/ZX703_A_Small-Molecule_Degrader_of_GPX4_Inducing_Ferroptosis_in_Human_Cancer_Cells/25225797

المؤلفون: Yurim Jeong, Se Been Kim, Chae-Eun Yang, Min Seo Yu, Wan-Su Choi, Youngwoo Jeon, Jung-Yeon Lim

المصدر: Frontiers in Oncology, Vol 13 (2023)

مصطلحات موضوعية: Burkitt’s lymphoma, EZH2, Btk, Proteolysis-targeting chimera, miR29b, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1252658/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/9b203ac2db194302a5f5d02fc7901d81

المؤلفون: Vicente, André Toscano de Sousa

مصطلحات موضوعية: Proteolysis-targeting chimera (PROTAC), Mouse Double Minute 2 (MDM2), p53, Degradação Direcionada de Proteínas, Descoberta de Fármacos anticancerígenos, Targeted Protein Degradation, Anticancer Drug Discovery

الاتاحة: https://hdl.handle.net/10316/105645

المؤلفون: Matthiesen, Rune, Rodriguez, Manuel S, Carvalho, Ana Sofia

المساهمون: Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT), Manuel S. Rodriguez, Rosa Barrio

المصدر: The Ubiquitin Code ; https://hal.science/hal-04269366 ; Manuel S. Rodriguez; Rosa Barrio. The Ubiquitin Code, 2602, Springer US, pp.205-214, 2023, Methods in Molecular Biology, 978-1-0716-2858-4. ⟨10.1007/978-1-0716-2859-1_15⟩ ; https://link.springer.com/protocol/10.1007/978-1-0716-2859-1_15

مصطلحات موضوعية: Ubiquitin proteasome system, Ubiquitin enrichment, Mass spectrometry, R programming language, Ubiquitin branch statistics, Proximity drugs, Proteolysis targeting chimera, [SDV.BC]Life Sciences [q-bio]/Cellular Biology

Relation: hal-04269366; https://hal.science/hal-04269366; https://hal.science/hal-04269366/document; https://hal.science/hal-04269366/file/Matthiesen,%20A%20Computational%20Tool%20for%20Analysis,%202023.pdf

الاتاحة: https://hal.science/hal-04269366
https://hal.science/hal-04269366/document
https://hal.science/hal-04269366/file/Matthiesen,%20A%20Computational%20Tool%20for%20Analysis,%202023.pdf
https://doi.org/10.1007/978-1-0716-2859-1_15

المؤلفون: Se Yong Park, Raju Gurung, Jung Ho Hwang, Ju-Hee Kang, Hyun Jin Jung, Alam Zeb, Jong-Ik Hwang, Sung Jean Park, Han-Joo Maeng, Dongyun Shin, Seung Hyun Oh

المصدر: Redox Biology, Vol 64, Iss , Pp 102783- (2023)

مصطلحات موضوعية: Proteolysis-targeting chimera (PROTAC), KEAP1, NRF2, Oxidative stress, Liver, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231723001842; https://doaj.org/toc/2213-2317

URL الوصول: https://doaj.org/article/c914f61dd15f42f592f9ec9242d4d5fa

المؤلفون: Jinho Seo, Doo-Byoung Oh

المصدر: Animal Cells and Systems, Vol 26, Iss 3, Pp 84-91 (2022)

مصطلحات موضوعية: Mannose-6-phosphate, lysosome, glycan, enzyme replacement theraphy and lysosome-targeting chimera, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1976-8354; https://doaj.org/toc/2151-2485

URL الوصول: https://doaj.org/article/342e055b8122472eb5cb2014f9d389d7

المؤلفون: Kwang‐Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin

المصدر: Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)

مصطلحات موضوعية: BMI1, degrader, embryonic ectoderm development (EED), polycomb repressive complex 1 (PRC1), proteolysis targeting chimera (PROTAC), RING1B, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/5c133b6443db4c6c8875a050ae0d44cd