المؤلفون: Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R. Schneider, Xin Zhang, Lena M. Berger, Benedict-Tilman Berger, Martin P. Schwalm, Nick A. Klopp, Jens T. Siveke, Stefan Knapp, Andreas C. Joerger

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target activity translated, nut midline carcinoma, future translational studies, could also show, choosing starting scaffolds, 100 nm range, guided optimization bromodomain, different cancer models, pancreatic cancer cells, potent dual bet, available dual bet, 50 , pancreatic cancer, dual bet, guided modification, cancer therapy, tp63 <, p57 <, myc <, hexim1 <, bet inhibition, two functionalities, tumor suppressor, treat tumors

Relation: https://figshare.com/articles/journal_contribution/Development_of_Potent_Dual_BET_HDAC_Inhibitors_via_Pharmacophore_Merging_and_Structure-Guided_Optimization/25117159

الاتاحة: https://doi.org/10.1021/acschembio.3c00427.s001