المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/16812172

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.s005

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Fine_motor_and_gait_changes_using_PCA_/16812163

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.s002

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Rhes_did_not_modulate_mTOR_signaling_at_12_months_in_mixed_gender_Q175_mice_/16812169

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.s004

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/S1_Raw_images_-/16812175

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.s006

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Body_weight_of_Q175_RhesKO_female_mice_from_21_to_54_weeks_of_age_/16812178

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g001

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Discriminant_vector_bar_graph_of_principal_component_PC_analysis_/16812181

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g002

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Overall_gait_score_in_Q175_female_mice_/16812184

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g003

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/MRI_analysis_of_Q175_Rhes_female_mice_at_6_12_months_of_age_/16812187

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g004

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Fig_5_-/16812190

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g005

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/RhesKO_did_not_modulate_autophagy_in_female_Q175_mice_/16812196

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g007

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/RhesKO_did_not_modulate_mTOR_signaling_in_female_Q175_/16812202

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g009

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/RhesKO_did_not_modulate_HTT_levels_in_female_Q175_/16812199

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g008

المؤلفون: Taneli Heikkinen (112431), Timo Bragge (9914696), Juha Kuosmanen (11564851), Teija Parkkari (570172), Sanna Gustafsson (3572969), Mei Kwan (108819), Jose Beltran (108823), Afshin Ghavami (108826), Srinivasa Subramaniam (11564854), Neelam Shahani (11564857), Uri Nimrod Ramírez-Jarquín (11564860), Larry Park (366213), Ignacio Muñoz-Sanjuán (11564863), Deanna M. Marchionini (4977116)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Science Policy, Mental Health, related small gtp, characterize multiple behavioral, whether rhes reduction, q175 phenotypic features, affect mtor signaling, global rhes knockout, genetic rhes knockout, mutant huntingtin levels, mutant huntingtin, modulate mtor, kinematic features, global rhesko, genetic rhesko, ubiquitously expressed, subtle attenuation, substantially ameliorate, severe pathology, polyglutamine tract, molecular endpoints, ko ), expansion mutation, detrimental effects, although huntingtin

Relation: https://figshare.com/articles/figure/Rhes_is_downregulated_in_the_striatum_of_mixed_gender_Q175_/16812205

الاتاحة: https://doi.org/10.1371/journal.pone.0258486.g010