المؤلفون: György Szabó (2361280), Péter Erdélyi (1495210), Sándor Kolok (3803884), Mónika Vastag (2361268), Attila S. Halász (10916714), Istvánné Kis-Varga (10916717), György I. Lévay (4960555), Zoltán Béni (1313397), János Kóti (2178280), István Greiner (3803863), György M. Keserű (1269681)

مصطلحات موضوعية: Medicine, Biotechnology, Sociology, Cancer, Space Science, Biological Sciences not elsewhere classified, Fragment-Based Optimization, allosteric modulators, metabotropic glutamate receptor -2, druglike properties, high-affinity mGluR 2 PAMs, migraine disease model, suboptimal drug-like profiles, mGluR 2 PAMs, dihydropyrazino-benzimidazolone sca., compound 34, scaffold-hopping attempts, proof-of-concept studies, alternative fragment-based optimiza., infraorbital nerve ligation, pharmacophore-guided approach

Relation: https://figshare.com/articles/journal_contribution/Fragment-Based_Optimization_of_Dihydropyrazino-Benzimidazolones_as_Metabotropic_Glutamate_Receptor_2_Positive_Allosteric_Modulators_against_Migraine/14724278

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00563.s002

المؤلفون: György Szabó (2361280), Péter Erdélyi (1495210), Sándor Kolok (3803884), Mónika Vastag (2361268), Attila S. Halász (10916714), Istvánné Kis-Varga (10916717), György I. Lévay (4960555), Zoltán Béni (1313397), János Kóti (2178280), István Greiner (3803863), György M. Keserű (1269681)

مصطلحات موضوعية: Medicine, Biotechnology, Sociology, Cancer, Space Science, Biological Sciences not elsewhere classified, Fragment-Based Optimization, allosteric modulators, metabotropic glutamate receptor -2, druglike properties, high-affinity mGluR 2 PAMs, migraine disease model, suboptimal drug-like profiles, mGluR 2 PAMs, dihydropyrazino-benzimidazolone sca., compound 34, scaffold-hopping attempts, proof-of-concept studies, alternative fragment-based optimiza., infraorbital nerve ligation, pharmacophore-guided approach

Relation: https://figshare.com/articles/dataset/Fragment-Based_Optimization_of_Dihydropyrazino-Benzimidazolones_as_Metabotropic_Glutamate_Receptor_2_Positive_Allosteric_Modulators_against_Migraine/14724275

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00563.s001