المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/journal_contribution/S1_Raw_images_-/14688771

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.s004

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/L136P_disturbs_cell_spreading_and_filopodia_formation_/14688780

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.g003

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/FMNL2_L136P_protein_regulation_is_dysfunctional_/14688774

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.g001

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/media/Live_cell_spreading_of_NIH_3T3_fibroblasts_expressing_FMNL2_L136P_/14688768

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.s003

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/media/Live_cell_spreading_of_NIH_3T3_fibroblasts_expressing_FMNL2_WT_/14688765

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.s002

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/FMNL2_L136P_expressing_NIH_3T3_Fibroblasts_show_reduced_cell_area_after_90_minutes_of_spreading_/14688762

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.s001

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/FMNL2_L136P_shows_an_altered_localization_pattern_/14688777

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.g002

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/FMNL2_L136P_affects_podosome-like_structures_in_THP-1_macrophages_/14688783

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.g004

المؤلفون: Raphael Trefzer (10884855), Orly Elpeleg (324361), Tatyana Gabrusskaya (10884858), Polina Stepensky (759105), Hagar Mor-Shaked (7547588), Robert Grosse (441122), Dominique T. Brandt (10884861)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, actin nucleation, IBD, actin dynamics, filopodia formation, FMNL 2 L 136P protein, subcellular mislocalization, FMNL 2 L 136P, FMNL 2 p.L 136P mutation, bowel disease Diaphanous, L 136P mutation, protein autoinhibition, THP, assembly factors, gain-of-function mechanism, Formin-like 2, dysregulated podosome formation, bowel disease, matrix degradation

Relation: https://figshare.com/articles/figure/The_formin_mutant_disturbs_matrix_degradation_in_THP-1_macrophages_/14688786

الاتاحة: https://doi.org/10.1371/journal.pone.0252428.g005