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المصدر: Regenerative Therapy, Vol 18, Iss, Pp 117-126 (2021)
Regenerative Therapyمصطلحات موضوعية: 0301 basic medicine, Medicine (General), ESC, embryonic stem cell, Adipose tissue, KSR, knockout serum replacement, 0302 clinical medicine, ATP4B, ATPase H+/K+ transporting beta subunit, Induced pluripotent stem cell, DMEM, Dulbecco's modified Eagle's medium, HE, hematoxylin and eosin, LIF, leukemia inhibitory factor, RLU, relative light units, Induced pluripotent stem cells, medicine.anatomical_structure, ssDNA, single stranded DNA, Differentiation, RT, room temperature, Original Article, medicine.drug, iPSC, induced pluripotent stem cell, Embryonic stem cells, PCNA, proliferating cell nuclear antigen, Biomedical Engineering, Immature teratoma, Biology, α-SMA, α-smooth muscle actin, Biomaterials, Andrology, 03 medical and health sciences, R5-920, PBS, phosphate buffered saline, Gastric mucosa, medicine, RAG, recombination activating gene, Cisplatin, CR, chemotherapeutic retroconversion, ALP, alkaline phosphatase, QH573-671, medicine.disease, Embryonic stem cell, MEF, mouse embryonic fibroblast, Transplantation, 030104 developmental biology, FCS, fetal calf serum, Cytology, 030217 neurology & neurosurgery, Immunostaining, Developmental Biology
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المؤلفون: Xianglin Zhang, Qi Zhang, Wenqing Tian, Chunqing Meng, Xiaodong Guo, Tingfang Sun, Keda Yu, Qiuyue Ding, Zekang Xiong, Bin Wu, Wancheng Zhang
المصدر: Bioactive Materials, Vol 6, Iss 11, Pp 4163-4175 (2021)
Bioactive Materialsمصطلحات موضوعية: Scaffold, Aptamer, QH301-705.5, Apt19s, aptamer 19s, BMD, bone mineral density, 0206 medical engineering, Biomedical Engineering, BMP2, Controlled delivery, CSD, critical-sized calvarial defect, 02 engineering and technology, Matrix (biology), Bone morphogenetic protein 2, Article, SIS, small intestine submucosa, Biomaterials, PVDF, polyvinylidene difluoride, BMP2, bone morphogenic protein 2, FBS, fetal bovine serum, Tissue engineering, ssDNA, single-stranded DNA, Biology (General), Rh6G, rhodamine 6G, Bone regeneration, Materials of engineering and construction. Mechanics of materials, BMSC, bone marrow-derived mesenchymal stem cell, Decellularization, FDA, US Food and Drug Administration, Chemistry, 3D, three-dimensional, Mesenchymal stem cell, CLSM, confocal laser scanning microscopy, ECM, decellularized matrix, PCL, polycaprolactone, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Cell recruitment, Cell biology, Transplantation, FTIR, Fourier transform infrared, H&E, hematoxylin and eosin, HA, hydroxyapatite, TA401-492, FITC, fluorescein isothiocyanate, Bone regeneration in situ, 0210 nano-technology, pBMP2, PlGF-2123-144*-fused BMP2, Biotechnology
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المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden
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المؤلفون: Taku Ozaki, Takumi Abe, Ken Itoh, Mayu Sugawara, Shuya Kasai
المصدر: Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101101-(2021)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: CPP, cell penetrating peptide, Proteases, QH301-705.5, Short Communication, Biophysics, PBS, phosphate-buffered saline, Mitochondrial calpain-1, Peptide, QD415-436, Mitochondrion, DMEM, Dulbecco's Modified Eagle Medium, Biochemistry, Oxytosis, Hippocampal HT22 cells, medicine, Neurodegeneration, Biology (General), BBB, blood–brain barrier, Hn-μCL, polyhistidine-conjugated μCL, chemistry.chemical_classification, Cell penetrating peptide, biology, MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, Glutamate receptor, Calpain, medicine.disease, Cell biology, AIF, apoptosis-inducing factor, ssDNA, single stranded DNA, chemistry, Cytoplasm, Cell-penetrating peptide, biology.protein, DAPI, 4′,6-diamidino-2-phenylindole
وصف الملف: application/pdf
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المؤلفون: Alexander Hergovich, Angeliki Ditsiou, Juan Jose Garcia-Gomez, Fumiko Esashi, Ramazan Gundogdu, Valenti Gomez, Victoria J. Spanswick, M. Kadir Erdogan, John A. Hartley
المصدر: Cellular Signalling
مصطلحات موضوعية: TCGA, The Cancer Genome Atlas, DSB, DNA double-strand break, PARP, poly(ADP-ribose) polymerase, DNA Repair, DNA repair, DNA damage, Poly ADP ribose polymerase, SSB, DNA single-strand break, Biology, Poly(ADP-ribose) Polymerase Inhibitors, IR, Ionising radiation, Article, DDR, DNA damage response, chemistry.chemical_compound, Homologous recombination DNA repair, Cell Line, Tumor, Neoplasms, medicine, ssDNA, single-stranded DNA, Humans, Homologous Recombination, MMC, mitomycin C, NDR, Nuclear Dbf2-related, DNA damage response signalling, MRN, MRE11-RAD50-NBS1, Cancer, Cell Biology, medicine.disease, Personalised PARP inhibitor treatments, NHEJ, non-homologous end-joining, MOB, Mps one binder, RNAi, RNA interference, chemistry, Cancer cell, PARP inhibitor, Cancer research, HR, homologous recombination, Homologous recombination, Mps one binder 2 (MOB2), DNA, DNA Damage
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المؤلفون: Susanne N. Weber, Frank Lammert
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1546-1547 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Cyt C, cytochrome c, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 8-OHdG, 8-hydroxy-2’-deoxyguanosine, C5, complement component-5, RC799-869, Ab, antibody, Anaphylatoxin, Con-A, concanavalin A, ALF, acute liver failure, ALT, alanine aminotransferase, ssDNA, single-stranded DNA, Humans, Medicine, mAb, monoclonal antibody, TNF-α, tumor necrosis factor α, Original Research, Membrane Attack Complex (MAC: C5b-9), KO, knockout, Hepatology, business.industry, C5aR, C5a receptor, Gastroenterology, Liver failure, D-GalN, d-galactosamine hydrochloride, ELISA, enzyme-linked immunosorbent assay, Liver Failure, Acute, Eculizumab, Diseases of the digestive system. Gastroenterology, WT, wild-type, IL, interleukin, Complement (complexity), Immunology, JNK, c-jun N-terminal kinase, LPS, lipopolysaccharide, MAC, membrane attack complex, HMGB-1, high-mobility group box-1, business, IgG, immunoglobulin
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المؤلفون: Soledad Marsile-Medun, Sam J. Wilson, Joshua B Singer, William Marciel de Souza, Tristan P.W. Dennis, Robert J. Gifford
المصدر: Virus Research
مصطلحات موضوعية: Circovirus, Cancer Research, Evolution, In silico, Virus Integration, viruses, animal diseases, Genome, Viral, Biology, Rep, replication associated protein, Genome, DNA sequencing, Article, Paleovirology, Evolution, Molecular, 03 medical and health sciences, ORF, open reading frame, Phylogenetics, Virology, biology.animal, ssDNA, single-stranded DNA, Animals, Circoviridae Infections, Phylogeny, 030304 developmental biology, CVe, endogenous circoviral element, Taxonomy, 0303 health sciences, 030306 microbiology, Endogenous, Vertebrate, Genetic Variation, virus diseases, biology.organism_classification, Infectious Diseases, Cap, capsid, Evolutionary biology, Metagenomics, Vertebrates
وصف الملف: application/pdf
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المؤلفون: Jin Inoue, Yuya Nishida, Yutaka Ito, Teppei Ikeya, Yasunori Shintani, Seiji Takashima, Tsutomu Mikawa, Ryoji Masui, Seiki Kuramitsu
المصدر: Biochemistry and Biophysics Reports
مصطلحات موضوعية: 0301 basic medicine, Conformational change, Biophysics, NAP, nucleoid-associated protein, Circular dichroism, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, HU, Transcription (biology), ssDNA, single-stranded DNA, Nucleoid, Thermus, NMR, nuclear magnetic resonance, CD, circular dichroism, Protein secondary structure, SLBP, stem-loop binding protein, dsDNA, double-stranded DNA, HSQC, heteronuclear single quantum coherence, Nucleoid-associated protein, Thermus thermophilus, biology.organism_classification, Molecular biology, NMR, genomic DNA, TtHU, Thermus thermophilus HU, 030104 developmental biology, chemistry, Structural change, Single-stranded DNA, DNA, Research Article
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المؤلفون: Gururaj Rao Kidiyoor, Amit Kumar, Marco Foiani
المصدر: DNA Repair
مصطلحات موضوعية: 0301 basic medicine, DNA Repair, Nuclear Envelope, Nucleolus, DNA repair, DNA damage, Cell Plasticity, Ataxia Telangiectasia Mutated Proteins, Biology, Biochemistry, Article, DDR, DNA damage response, PIKK, Phosphatidylinositol 3-Kinase-related Kinases, 03 medical and health sciences, PIKK, PTM, Post Translation Modification, medicine, Humans, ATR, Ataxia Telangiectasia and Rad3-related, NE, Nuclear Envelope, Molecular Biology, Centrosome, ATRIP, ATR interacting protein, Kinase, RPA, Replication Protein A, FAT, domainFRAP-ATM-TRRAP domain, DNA, Cell Biology, Cellular plasticity, medicine.disease, Cell biology, Eukaryotic Cells, ssDNA, single stranded DNA, ATR, 030104 developmental biology, Ataxia-telangiectasia, HEAT, Huntingtin, Elongation factor 3 Alpha-regulatory subunit of protein phosphatase 2A and TOR1, Cell Nucleolus, DNA Damage
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المؤلفون: Kamila K. Myka, Jan-Gert Brüning, Peter McGlynn
المصدر: Journal of Molecular Biology
مصطلحات موضوعية: 0301 basic medicine, DNA, Single-Stranded, Gene Expression, DNA repair, Biology, DNA replication, Pre-replication complex, Origin of replication, Article, 03 medical and health sciences, Minichromosome maintenance, Control of chromosome duplication, Structural Biology, Escherichia coli, ssDNA, single-stranded DNA, Molecular Biology, dnaB helicase, disease, Escherichia coli Proteins, Molecular biology, RNA Helicase A, DnaA, 3. Good health, 030104 developmental biology, bacteria, transcription, dnaC, DnaB Helicases, genome stability, DAPI, 4′,6-diamidino-2-phenylindole
وصف الملف: application/pdf
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المصدر: Chemical Engineering Journal
مصطلحات موضوعية: SODIS, Solar water disinfection, General Chemical Engineering, BCoV, Bovine Enteric Coronavirus), HKU1, Human CoV1, SBR, Sequential Batch Reactor, RNA, Ribose nucleic acid, βCoV, Betacoronavirus, T99.9, First order reaction time required for completion of 99.9%, 02 engineering and technology, WWT, Wastewater Treatment, 01 natural sciences, MERS-CoV, Middle East Respiratory Syndrome Coronavirus, FIPV, Feline infectious peritonitis virus, ORF, Open Reading Frame, PPE, Personal Protective Equipment, ASP, Activate Sludge Process, WBE, Wastewater-Based Epidemiology, PCR, Polymerase Chain Reaction, PAA, Para Acetic Acid, Coronavirus, AOPs, Advanced Oxidation Processes, HAV, Hepatitis A virus (HAV), Cl−, Chlorine, NCoV, Novel coronavirus, HCoV, Human CoV, virus diseases, ds, Double Stranded, Enteric virus, BoRv, Bovine Rotavirus Group A, ssDNA, Single Stranded DNA, PEG, Polyethylene Glycol, ClO2, Chlorine dioxide, 0210 nano-technology, DMEM, Dulbecco’s Modified Eagle Medium, TGEV, Transmissible Gastroenteritis, MHV, Murine hepatitis virus, EV, Echovirus 11, US-EPA, United States Environmental Protection Agency, AH, Absolute Humidity, TGEV, Porcine Coronavirus Transmissible Gastroenteritis Virus, dsDNA, Double Stranded DNA, H3N2, InfluenzaA, WWTPs, Wastewater Treatment Plants, DBP, Disinfection by-products, O2, Singlet Oxygen, Article, T90, First order reaction time required for completion of 90%, (h+), Photoholes, NTP, Non-Thermal Plasma, CVE, Coxsackievirus B5, H2O2, Hydrogen Peroxide, MWCNTs, Multiwalled Carbon Nanotubes, Enveloped virus, HEV, Hepatitis E virus, PFU, Plaque Forming Unit, CCA, Carbon Covered Alumina, Tyr, Tyrosine, H6N2, Avian influenza virus, ssRNA, Single Stranded RNA, Outbreak, PVDF, Polyvinylidene Fluoride, Qβ, bacteriophages, Virology, 0104 chemical sciences, NGS, Next generation sequencing, RONS, Reactive Oxygen and/or Nitrogen Species, Betacoronavirus, RH, Relative Humidity, viruses, SARS-CoV-1, Severe Acute Respiratory Syndrome Coronavirus 1, medicine.disease_cause, Industrial and Manufacturing Engineering, PMMoV, Pepper Mild Mottle Virus, dPCR, Digital PCR, FC, Free Chlorine, Trp, Tryptophan, E gene, Envelope protein gene, BVDV1, Bovine Viral Diarrhea Virus Type 1, MALDI-TOF MS, Mass Spectrometry, Pandemic, CNT, Carbon Nanotubes, N gene, Nucleocapsid protein gene, ICC-PCR, Integrated Cell Culture with PCR, DNA, deoxyribose nucleic acid, UV, Ultraviolet, Sewage, JCV, JCV polyomavirus, biology, PV-3, Poliovirus 3, Transmission (medicine), BSL, Biosafety Level, 021001 nanoscience & nanotechnology, RVA, Rotaviruses A, PTAF, Photocatalytic Titanium Apatite Filter, COVID-19, Coronavirus Disease 2019, CRFK, Crandell Reese feline kidney cell line (CRFK), qRT-PCR, quantitative RT-PCR, A-WWTS, Algal-WWTS, Cys, Cysteine, Middle East respiratory syndrome coronavirus, Context (language use), 010402 general chemistry, Airborne transmission, PMR, Photocatalytic Membrane Reactors, ACE2, Angiotensin-converting enzyme 2, PEC, Photoelectrocatalytical, medicine, Environmental Chemistry, FFP3, Filtering Face Piece, Met, Methionine, ComputingMethodologies_COMPUTERGRAPHICS, Aerosols, DBT, L2 and Delayed Brain Tumor Cell Cultures, COVID-19, PV-1, Polivirus-1, αCoV, Alphacoronavirus, MNV-1, Murine Norovirus, General Chemistry, log10, logarithm with base 10, ss, Single Stranded, HAdV, Human Adenovirus, biology.organism_classification, MBR, Membrane Bioreactor (MBR), Disinfection, BVDV2, Bovine Viral Diarrhea Virus Type 2, GI, Gastrointestinal tract, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2, O3, Ozone, RT-PCR, Real Time Polymerase Chain Reaction, STP, Sewage Treatment Plant, +ssRNA, Positive Sense Single-Stranded RNA
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المؤلفون: Alexander Holbrook, Halle Mallard, Meghan Biegert, Natasha Kreiling, Grace Su, Manohar Kodavati, Megan Perry, Gargi Ghosal, Sai Sundeep Kollala
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, DNA Repair, SPRTN, TOP1, topoisomerase I, DPC, DNA–protein cross-link, Biochemistry, Deubiquitinating enzyme, chemistry.chemical_compound, Transcription (biology), DSB, double-stranded DNA breaks, TOP2, topoisomerase II, deubiquitination, TOP2-ccs, TOP2 cleavage complexes, DNMT1, DNA methyl transferase 1, dsDNA, double-stranded DNA, biology, DUB, deubiquitinase, RADAR, rapid approach to DNA adduct recovery, DPC, Chromatin, Cell biology, DNA-Binding Proteins, Cross-Linking Reagents, Co-IP, Co-Immunoprecipitations, SFB, S-FLAG-streptavidin binding peptide, TAP-MS, tandem-affinity purification and mass spectrometry, embryonic structures, CPT, camptothecin, DPC repair, MMC, mitomycin c, Research Article, DNA repair, USP, ubiquitin specific protease, TOP1-ccs, Genomic Instability, Cell Line, 03 medical and health sciences, RJALS, Ruijs–Aalfs syndrome, Cell Line, Tumor, NER, nucleotide excision repair, TOP1-ccs, TOP1 cleavage complexes, ssDNA, single-stranded DNA, Humans, SSB, single-stranded DNA breaks, TLS, translesion synthesis, monoubiquitinated SPRTN, Molecular Biology, Ub-SPRTN, monoubiquitinated SPRTN, 030102 biochemistry & molecular biology, Ubiquitination, Cell Biology, USP11, 030104 developmental biology, chemistry, Proteolysis, biology.protein, DNMT1, IR, ionizing radiation, Thiolester Hydrolases, HR, homologous recombination, Homologous recombination, HU, hydroxyurea, DNA, Nucleotide excision repair
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المؤلفون: Hari S. Misra, Neha Pandey, Reema Chaudhary, Ganesh Kumar Maurya
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: DNA Replication, 0301 basic medicine, chromosomes, DNA Repair, DNA replication initiation, DNA repair, Mutant, radiation biology, PIR, post irradiation recovery, Origin of replication, Radiation Tolerance, FRET, fluorescence resonance energy transfer, Biochemistry, Genome, BACTH, bacterial two-hybrid, 03 medical and health sciences, Plasmid, Bacterial Proteins, Chromosome Segregation, ChrI, chromosome I, ssDNA, single-stranded DNA, ATPase, Protein Interaction Domains and Motifs, Molecular Biology, Ploidies, dsDNA, double-stranded DNA, 030102 biochemistry & molecular biology, biology, CTD, C-terminal deletion, Deinococcus radiodurans, Cell Biology, biology.organism_classification, Cell biology, origin of replication, protein–protein interaction, 030104 developmental biology, DNA Gyrase, Deinococcus, bacterial genetics, metabolic regulation, Trans-acting, DNA–protein interaction, Cell Division, Genome, Bacterial, ChrII, chromosome II, Plasmids, Research Article
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المؤلفون: David Cortez, Vaughn Thada
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Cell cycle checkpoint, DNA Repair, TOPBP1, DNA topoisomerase II binding protein 1, replication stress response, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, DNA damage response, Biochemistry, phosphatidylinositol 3-kinase related protein kinase, MRN, MRE11/RAD50/NBS1 complex, Phosphorylation, ATRIP, ATR interacting protein, ATM, ataxia telangiectasia mutated, Chemistry, Nuclear Proteins, ATR-Interacting Protein, ETAA1, ETAA1 activator of ATR kinase, BRCT, BRCA1 C terminus, Cell biology, DNA-Binding Proteins, FKBP, FK-506 binding protein, FKBP, ATR, ataxia telangiectasia and Rad3-related, Antigens, Surface, cell cycle checkpoint, AAD, ATR activation domain, CPT, camptothecin, TOPBP1, biological phenomena, cell phenomena, and immunity, Dimerization, RPA, Protein Binding, Signal Transduction, Research Article, DNA Replication, DNA damage, DNA repair, RPA, replication protein A, 03 medical and health sciences, Protein Domains, stomatognathic system, Cell Line, Tumor, ssDNA, single-stranded DNA, Humans, Molecular Biology, Replication protein A, Protein kinase B, Adaptor Proteins, Signal Transducing, 030102 biochemistry & molecular biology, AKT, AKT serine/threonine kinase 1, ATR activation domain, Cell Biology, ATR, 030104 developmental biology, MBP, maltose binding protein, ETAA1, Carrier Proteins, HU, hydroxyurea, Ataxia telangiectasia and Rad3 related, DNA Damage
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المؤلفون: Michael A. Trakselis, Shivasankari Gomanthinayagam, David R. McKinzey, Elizabeth P. Jeffries, Kathleen N. Klinzing, Wezley C Griffin, Aleksandar Rajkovic
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: WT, wild type, 0301 basic medicine, PARP, poly(ADP-ribose) polymerase, RAD51, homologous recombination, BRCA1, breast cancer type 1 susceptibility protein, Biochemistry, DMEM, Dulbecco’s modified Eagle’s medium, GST, glutathione S-transferase, CTE, C-terminal extension, PVDF, polyvinylidene difluoride, BME, β-mercaptoethanol, DAPI, 4’,6-diamindino-2-phenylindole, IPTG, isopropyl β-D-thiogalactopyranosidase, BRCA2, breast cancer type 2 susceptibility protein, MCM9, BER, base excision repair, CD, circular dichroism, FA, Fanconi anemia, SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, mitomycin C, GFP, green fluorescent protein, U2OS, human bone osteosarcoma epithelial cells, Antibiotics, Antineoplastic, dsDNA, double-stranded DNA, Minichromosome Maintenance Proteins, biology, Chemistry, XRCC, X-ray repair cross complementing, BRC variant motif, HRP, horseradish peroxidase, MMC, mitomycin-C, cNLS, classic NLS, Cell biology, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, HEK, human embryonic kidney (cells), EBV, Epstein–Barr virus, DNA mismatch repair, Research Article, BRC, breast cancer, DNA damage, DNA repair, Mitomycin, LPEI, linear polyethyleneimine, PBS, phosphate-buffered saline, NLS, pNLS, putative NLS, MMR, mismatch repair, TEV, tobacco etch virus, RPA, replication protein A, 03 medical and health sciences, FBS, fetal bovine serum, Cell Line, Tumor, BRCv, BRC variant motif, NER, nucleotide excision repair, RPMI, Roswell Park Memorial Institute media, ssDNA, single-stranded DNA, Humans, DSB, double-strand break, NTD, N-terminal domain, TLS, translesion synthesis, pCHK1, phosphorylated checkpoint kinase 1, Molecular Biology, Replication protein A, KD, knockdown, KO, knockout, MCM8, EDTA, ethylenediaminetetraacetic acid, MRN, Mre11/ Rad50/ Nbs1 complex, 030102 biochemistry & molecular biology, Mitomycin C, Y2H, yeast two-hybrid, Helicase, OD, ocular density, Cell Biology, ICL, interstrand cross-link, Cis-Pt, cisplatin, HEK293 Cells, 030104 developmental biology, PMSF, phenylmethylsulfonyl fluoride, NLS, nuclear localization signal, Rad51, biology.protein, BSA, bovine serum albumin, Rad51 Recombinase, HEPES, hydroxyethyl piperazineethanesulfonic acid, MCM, minichromosomal maintenance, HR, homologous recombination, Homologous recombination, Nuclear localization sequence, DNA Damage, Nucleotide excision repair
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المؤلفون: Qu Lihua, Haitao Liu, Zhongbo Yu, Xiangchen Guan, Shuang Guo, Huang Wei, Fuping Sun, Huiru Zou, Lin Liang, Wei Zhang, Hongrui Yuan, Wang Zeyu
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Base pair, single-molecule biophysics, SPR, surface plasmon resonance, Computational biology, Biochemistry, Epigenesis, Genetic, Mixed Function Oxygenases, Magnetics, 03 medical and health sciences, chemistry.chemical_compound, CGI, CpG island (CGI), BP, base-pair, Proto-Oncogene Proteins, ssDNA, single-stranded DNA, Humans, Protein–DNA interaction, Epigenetics, Molecular Biology, Binding Sites, multiplexing, DNA methylation, dsDNA, double-stranded DNA, 030102 biochemistry & molecular biology, WLC, worm-like chain model, Cell Biology, Methylation, Single Molecule Imaging, molecular dynamics, DNA Demethylation, DNA-Binding Proteins, 030104 developmental biology, DNA demethylation, TET1, ten-eleven translocation enzyme, CpG site, chemistry, Multiprotein Complexes, protein–DNA interaction, CpG Islands, magnetic tweezers, DNA, Research Article
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المؤلفون: Antony W. Braithwaite, Annette Lasham, Ming-Wei Wang, Alexander Trevarton, Jack U. Flanagan, Yan Zhou, Gordon W. Rewcastle, Dehua Yang, Cristin G. Print, Peter R. Shepherd
المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 997-1007 (2019)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Original article, DMSO, dimethylsulfoxide, YBX1, Y-box binding protein gene 1, HTS, high-throughput screening, YB-1, cDNA, complementary DNA, 03 medical and health sciences, 0302 clinical medicine, AlphaScreen, EGR1, early growth response 1, ssDNA, single-stranded DNA, shRNA, short-hairpin RNA, YB-1, Y-box binding protein-1, E2F1, Luciferase, NTD, N-terminal domain, General Pharmacology, Toxicology and Pharmaceutics, E2F1, E2F transcription factor 1, Transcription factor, Cancer, 030304 developmental biology, siRNA, small-interfering RNA, 0303 health sciences, dsDNA, double-stranded DNA, Chemistry, Drug discovery, lcsh:RM1-950, Small molecule, CSD, cold shock domain, CTD, C-terminal domain, DNA binding site, lcsh:Therapeutics. Pharmacology, Targeted drug delivery, Biochemistry, 030220 oncology & carcinogenesis, Nucleic acid, Single-stranded DNA
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المؤلفون: Eliana M. Coccia, Angela Battistini
المصدر: Seminars in Immunology
مصطلحات موضوعية: Evasion mechanism, ssRNA, single-stranded RNA, DHX, DEAH box protein, IRF, IFN regulatory factor, miR, microRNA, TLRs, Toll-like receptors, TREX1, three prime repair exonuclease 1, CARD, caspase recruitment domain, MAM, mitochondrial associated membranes, tRNA, transfer RNA, PRR, pattern-recognition receptors, NSP, nonstructural protein, DDX, DEAD box protein, SIV, simian immunodeficiency virus, LRRFIP1, extrachromosomal histone, CypA, cyclophilin A, RT, reverse transcription, ASC, apoptosis-associated speck-like protein containing a CARD, CLRs, C-type lectin receptors, Acquired immune system, Virus, STAT, signal transducer and activator of transcription, iNOS, inducible nitric oxide synthase 1, Interferon Type I, MAVS, mitochondrial antiviral signaling protein, Interferon, JAK, Janus kinase, AIM2, absent in melanoma 2, dNTPase, deoxynucleotide triphosphate triphosphohydrolase, RLRs, (RIG)-I-like receptors, Immunology, IFN-α/β, IFN-I, JEV, Japanese encephalitis virus, H2B, leucine rich repeat (in FLII) interacting protein, TRAF, TNF receptor associated factor, CDNs, cyclic dinucleotides, cIAP, cellular inhibitors of apoptosis, Article, AIM2, APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like, ssDNA, single-stranded DNA, SLFN11, schlafen family member 11, SAMHD1, SAM domain and HD domain-containing protein 1, DAI, DNA-dependent activator of IFN-regulatory factors, SARS, severe acute respiratory syndrome, Immune Evasion, MDA5, melanoma differentiation-associated gene-5, NO, nitric oxide, Bacteria, ITIM, immunoreceptor tyrosine-based inhibition motif, MERS, Middle East respiratory syndrome, ISRE, IFN-stimulated response element, Virology, Signaling, RIG-I, retinoic acid-inducible gene 1, cGAS, cyclic GMP-AMP synthase, TRIF, TIR domain-containing adaptor inducing IFN-β, Viral replication, TBK1, TANK-binding kinase 1, ISG15, IFN-stimulated gene 15, NLRs, nucleotide-binding oligomerization domain-like receptors, SAMHD1, PACT, PKR-associated activator, TRIM, tripartite motif, DENV, dengue virus, ISGF3, interferon-stimulated gene factor 3, IFN-stimulated genes, MyD88, myeloid differentiation primary response gene 88, DNA, deoxyribonucleic acid, pDCs, plasmacytoid dendritic cells, CPSF6, cleavage and polyadenylation specificity factor subunit 6, PKR, double-stranded RNA-activated protein kinase, CoV, Coronavirus, Immunology and Allergy, IKK, inhibitor of kB kinase, MAPKs, mitogen-activated protein kinases, SOCS, suppressor of cytokine signaling, RIG-I, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, Pattern recognition receptor, IFITM, IFN-induced transmembrane protein, MDA5, Bacterial Infections, mRNA, messenger RNA, RIP, receptor-interacting serine-threonine kinase, dsRNA, double-strand RNA, WNV, West Nile virus, Virus Diseases, HCV, hepatitis C virus, Viruses, HIV-1, human immunodeficiency virus 1, LPS, lipopolysaccharide, DCs, dendritic cells, PAMP, pathogen-associated molecular pattern, Signal Transduction, TIR, Toll-Interleukin-1 receptor, NLRP3, NACHT LRR and PYD domains-containing protein 3, Biology, PLP, papain-like protease, ER, endoplasmic reticulum, NOD, nucleotide-binding oligomerization domain, IRAK, IL-1R-associated kinases, IFI16, interferon gamma-interferon-inducible protein 16, IFN, interferon, IFI16, NADPH, nicotinamide adenine dinucleotide phosphate, STING, stimulator of IFN genes protein, IFIT, IFN-induced tetratricopeptide repeat proteins, RNA, ribonucleic acid, IPS1, IFN-β-promoter stimulator 1, Type II IFN, IFN-II, ISGs, IFN stimulated genes
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19
المؤلفون: Lydia Teboul, Heather Cater, Frances M. Ashcroft, Michelle Stewart, Chris Church, Gregor Sachse, Roger D. Cox
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: Male, 0301 basic medicine, WT, (wildtype), endocrine system diseases, MRI, (magnetic resonance imaging), DEXA, (Dual-energy X-ray absorptiometry), SOPF, (specific opportunistic pathogen-free), WAT, (white adipose tissue), Body composition, Mineralization (biology), FTO gene, Cas9, (CRISPR associated protein 9), CV, (calorific value), m6Am, (N6,2′-O-dimethyladenosine), Mice, BMI, (Body mass index), EE, (Energy expenditure), Demethylase activity, RER, (respiratory exchange ratio), Mice, Knockout, education.field_of_study, Chemistry, BMC, (bone mineral content), Body size, pathological conditions, signs and symptoms, CRISPR, (clustered regularly interspaced short palindromic repeats), 3. Good health, Normal bone, BMD, (bone mineral density), Molecular Medicine, Female, ELISA, (enzyme-linked immunosorbent assay), ssDNA, (single-stranded DNA), Bone mineralization, medicine.medical_specialty, Population, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Locus (genetics), FTO protein, Article, FTO, (Fat mass and obesity-associated protein), Mouse model, 03 medical and health sciences, Calcification, Physiologic, Internal medicine, medicine, Animals, Protein Methyltransferases, education, Molecular Biology, Messenger RNA, Bone Development, KO, (knockout), SEM, (standard error of the mean), EMPReSS, (European Phenotyping Resource for Standardised Screens from EUMORPHIA), nutritional and metabolic diseases, medicine.disease, Obesity, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Animals, Newborn
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20
المؤلفون: K. Muniyappa, Bhakti Basu, Shree Kumar Apte, Aman Kumar Ujaoney
المصدر: FEBS Open Bio, Vol 5, Iss 1, Pp 378-387 (2015)
FEBS Open Bioمصطلحات موضوعية: QH301-705.5, SsbC, C-terminal Ssb, Biology, Biochemistry, DNA-binding protein, EMSA, Article, General Biochemistry, Genetics and Molecular Biology, Single-stranded binding protein, chemistry.chemical_compound, OB fold, oligonucleotide/oligosaccharide binding fold, Oligosaccharide binding, Deinococcus radiodurans, RPA, Replication protein A, ssDNA, single-stranded DNA, Ssb protein, Biology (General), Replication protein A, SsbN, N-terminal Ssb without connector, RecA, Strand exchange, Oligonucleotide, Topoisomerase, Ssb, single-stranded DNA binding protein, biology.organism_classification, Molecular biology, SsbNC, N-terminal Ssb with connector, stomatognathic diseases, chemistry, Topoisomerase activity, biology.protein, ESDSA, extended synthesis-dependent strand annealing, OB folds, DNA
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