المؤلفون: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall, Laura B. Duvall

المصدر: Parasites & Vectors, Vol 17, Iss 1, Pp 1-12 (2024)

مصطلحات موضوعية: Mosquito, Aedes aegypti, Neuropeptide Y, Host-seeking, Small-molecule agonist, Structure-guided design, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-3305

URL الوصول: https://doaj.org/article/b21dceefdf9643779d97fcff213cb8ff

المؤلفون: Yue Tang, Zijian Zhong, Huijin Mao, Yihua Chen

المصدر: Clinical and Translational Medicine, Vol 14, Iss 11, Pp n/a-n/a (2024)

مصطلحات موضوعية: across kingdom, ALPK1, HBE, innate immune, NDP‐β‐d‐manno‐heptose, small molecule agonist, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2001-1326

URL الوصول: https://doaj.org/article/6916107fc3854ba4a33ce4275dd47d4b

المؤلفون: Robert Ardecky, Daniela G. Dengler, Kaleeckal G. Harikumar, Mathew M. Abelman, Jiwen Zou, Bryan A. Kramer, Santhi Reddy Ganji, Steve Olson, Alina Ly, Nikhil Puvvula, Chen-Ting Ma, Raghuveer Ramachandra, Eduard A. Sergienko, Laurence J. Miller

المصدر: SLAS Discovery, Vol 29, Iss 6, Pp 100176- (2024)

مصطلحات موضوعية: Secretin receptor, G protein-coupled receptor, Structure-activity relationships, Small molecule agonist, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555224000388; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/3eddfc13db42404aa4f87b29244f0ab2

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/journal_contribution/S1_File_-/19067182

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.s008

المؤلفون: Emma D Deeks (4985300)

مصطلحات موضوعية: Medicine, Chiglitazar, non-thiazolidinedione small-molecule agonist, Pan-PPAR agonist, type 2 diabetes, non-alcoholic steatohepatitis, Adis Insight Report, Adis Drug Reviews

Relation: https://figshare.com/articles/online_resource/Chiglitazar_First_Approval/16992856

الاتاحة: https://doi.org/10.6084/m9.figshare.16992856.v1

المؤلفون: Sanju Narayanan (2449750), Shaobin Wang (1554541), Vineetha Vasukuttan (5202884), Ravi Kumar Vyas Devambatla (10291090), Donghua Dai (10291093), Chunyang Jin (1327155), Rodney Snyder (1331475), Lucas Laudermilk (9655858), Scott P. Runyon (1315095), Rangan Maitra (1893976)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Compound 13, weight loss, apelinergic system, liver microsome stability, compound, liver steatosis, novel pyrazole-based agonist scaffold, pharmacokinetic profile, agonist potency, ADME properties, glucose utilization, apelin receptor, Metabolic Syndrome, disease-associated biomarkers, vivo investigation, cAMPi EC 50, apelin peptides, diet-induced obesity, mouse model, DIO, syndrome, small-molecule agonist, Systematic modification

Relation: https://figshare.com/articles/journal_contribution/Pyrazole_Agonist_of_the_Apelin_Receptor_Improves_Symptoms_of_Metabolic_Syndrome_in_Mice/14200009

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01448.s001

المؤلفون: Leila Motedayen Aval, James E. Pease, Rohini Sharma, David J. Pinato

المصدر: Journal of Clinical Medicine; Volume 9; Issue 10; Pages: 3323

مصطلحات موضوعية: cGAS, STING, immune checkpoint inhibitors (ICI), cyclic dinucleotides (CDNs), small molecule agonist, STING agonists, immune therapy, drug delivery systems (DDS)

وصف الملف: application/pdf

Relation: Oncology; https://dx.doi.org/10.3390/jcm9103323

الاتاحة: https://doi.org/10.3390/jcm9103323

المؤلفون: Tom Van Loy, Steven De Jonghe, Karolien Castermans, Wouter Dheedene, Reinout Stoop, Lars Verschuren, Matthias Versele, Patrick Chaltin, Aernout Luttun, Dominique Schols

مصطلحات موضوعية: Pharmacology, Receptors, CXCR, Pulmonary Fibrosis, Endothelial Cells, Preclinical models, Cell Biology, Fibrosis, Chemokine CXCL12, Atypical chemokine receptor 3, Cellular and Molecular Neuroscience, Mice, Liver, Molecular Medicine, Animals, Small molecule agonist, Molecular Biology, Lung, beta-Arrestins

وصف الملف: Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6527aa3bd4c5a21248fefd1cffeb2c55
https://lirias.kuleuven.be/handle/20.500.12942/695730

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Western_blotting_validation_of_rabbit_anti-TRPA1_antibody_from_St_John_s_laboratory_STJ193121_/19066422

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.s001

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/dataset/S2_Data_-/19067170

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.s005

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Bladder_VEGF_sub_A_sub_instillations_caused_changes_in_mRNA_expression_in_TRPA1_and_nNOS_genes_in_lumbosacral_DRG_/19067197

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g004

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Intravesical_instillation_of_VEGF_sub_A_sub_led_to_visceral_mechanical_hypersensitivity_/19067188

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g002

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Intravesical_instillation_of_VEGF_sub_A_sub_did_not_affect_spontaneous_voiding_behavior_in_awake_mice_/19067185

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g001

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Intravesical_instillation_of_VEGF_sub_A_sub_did_not_affect_intrinsic_detrusor_contractility_but_enhanced_RTX-sensitive_nerve-mediated_detrusor_strip_contractility_in_female_mice_/19067191

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g003

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Bladder_VEGF_sub_A_sub_instillation_led_to_an_up-regulation_of_TRPA1_in_lumbosacral_DRG_/19067206

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g005

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Pharmacogenetic_inhibition_of_lumbosacral_sensory_neurons_alleviated_VEGF-induced_visceral_hypersensitivity_in_vivo_/19067218

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g007

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Pharmacogenetic_inhibition_of_lumbosacral_DRG_neurons_via_AAV-mediated_Gi-DREADD_expression_led_to_visceral_mechanical_analgesia_/19067212

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.g006

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/dataset/Primary_and_secondary_antibodies_used_/19067230

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.t002

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/dataset/Primer_sequences_used_in_qPCR_experiments_/19067224

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.t001

المؤلفون: Alison Xiaoqiao Xie (6196883), Nao Iguchi (11999295), Taylor C. Clarkson (11999298), Anna P. Malykhina (558073)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Physiology, Biotechnology, Cancer, Science Policy, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, work also aimed, small molecule agonist, sensitive detrusor contractility, reversing peripheral sensitization, peripheral nervous system, mediated neuronal silencing, associated viral vector, lumbosacral sensory neurons, urinary bladder led, strong therapeutic potential, induced visceral hypersensitivity, lumbosacral drg neurons, div >< p, ), completely reversed vegf, alleviating ucpps symptoms, visceral hypersensitivity, lumbosacral drg

Relation: https://figshare.com/articles/figure/Anti-TRPA1_antibody_validation_using_immunofluorescence_labeling_in_mouse_DRGs_/19066425

الاتاحة: https://doi.org/10.1371/journal.pone.0262769.s002