المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/journal_contribution/Primers_used_for_real-time_PCR_in_this_study_/25292161

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s010
https://figshare.com/articles/journal_contribution/Primers_used_for_real-time_PCR_in_this_study_/25292161

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/Only_microtubule_destabilizers_boosted_cGAMP-meditated_immune_responses_in_THP1-Lucia_ISG_cells_/25292134

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s001
https://figshare.com/articles/figure/Only_microtubule_destabilizers_boosted_cGAMP-meditated_immune_responses_in_THP1-Lucia_ISG_cells_/25292134

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_enhanced_the_antiviral_effects_of_cGAMP_in_a_STING-dependent_manner_i_in_vivo_i_/25292155

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s008
https://figshare.com/articles/figure/MMAE_enhanced_the_antiviral_effects_of_cGAMP_in_a_STING-dependent_manner_i_in_vivo_i_/25292155

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_amplified_the_STING_signaling_cascade_by_increasing_the_number_of_STING_puncta_induced_by_CDNs_/25292143

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s004
https://figshare.com/articles/figure/MMAE_amplified_the_STING_signaling_cascade_by_increasing_the_number_of_STING_puncta_induced_by_CDNs_/25292143

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_directly_enhanced_the_cGAMP-STING_signaling_pathway_/25292140

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s003
https://figshare.com/articles/figure/MMAE_directly_enhanced_the_cGAMP-STING_signaling_pathway_/25292140

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_enhanced_cGAMP-mediated_antiviral_activity_i_in_vitro_i_/25292149

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s006
https://figshare.com/articles/figure/MMAE_enhanced_cGAMP-mediated_antiviral_activity_i_in_vitro_i_/25292149

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/Multiple_microtubule_destabilizers_altered_STING_trafficking_pattern_during_cGAMP-mediated_STING_activation_/25292146

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s005
https://figshare.com/articles/figure/Multiple_microtubule_destabilizers_altered_STING_trafficking_pattern_during_cGAMP-mediated_STING_activation_/25292146

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_specifically_increased_cGAMP-mediated_immune_response_in_a_STING-dependent_manner_/25292137

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s002
https://figshare.com/articles/figure/MMAE_specifically_increased_cGAMP-mediated_immune_response_in_a_STING-dependent_manner_/25292137

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/media/STING-GFP_trafficking_/25292158

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s009
https://figshare.com/articles/media/STING-GFP_trafficking_/25292158

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_boosted_the_cGAMP-mediated_STING_pathway_by_increasing_STING-containing_membrane_puncta_numbers_and_the_extent_of_STING_oligomerization_/25292173

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g004
https://figshare.com/articles/figure/MMAE_boosted_the_cGAMP-mediated_STING_pathway_by_increasing_STING-containing_membrane_puncta_numbers_and_the_extent_of_STING_oligomerization_/25292173

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MDAs_including_MMAE_enhanced_the_cGAMP-mediated_STING_pathway_/25292164

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g001
https://figshare.com/articles/figure/MDAs_including_MMAE_enhanced_the_cGAMP-mediated_STING_pathway_/25292164

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_changed_STING_trafficking_routes_and_promoted_cGAMP-mediated_STING_activity_/25292176

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g005
https://figshare.com/articles/figure/MMAE_changed_STING_trafficking_routes_and_promoted_cGAMP-mediated_STING_activity_/25292176

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_synergized_with_cGAMP-mediated_STING_signaling_to_show_potent_and_broad_antiviral_activity_i_in_vitro_i_/25292152

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.s007
https://figshare.com/articles/figure/MMAE_synergized_with_cGAMP-mediated_STING_signaling_to_show_potent_and_broad_antiviral_activity_i_in_vitro_i_/25292152

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_relied_on_the_host_STING_pathway_to_enhance_cGAMP_antiviral_immune_response_/25292182

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g007
https://figshare.com/articles/figure/MMAE_relied_on_the_host_STING_pathway_to_enhance_cGAMP_antiviral_immune_response_/25292182

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_specifically_enhanced_the_cGAMP-STING-mediated_NF-kB_immune_response_/25292167

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g002
https://figshare.com/articles/figure/MMAE_specifically_enhanced_the_cGAMP-STING-mediated_NF-kB_immune_response_/25292167

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_enhanced_the_activation_of_STING_pathways_mediated_by_distinct_CDNs_in_a_direct_STING-IRF3_dependent_manner_/25292170

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g003
https://figshare.com/articles/figure/MMAE_enhanced_the_activation_of_STING_pathways_mediated_by_distinct_CDNs_in_a_direct_STING-IRF3_dependent_manner_/25292170

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/MMAE_alone_had_antiviral_effects_and_also_further_amplified_the_cGAMP-mediated_antiviral_immune_response_/25292179

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g006
https://figshare.com/articles/figure/MMAE_alone_had_antiviral_effects_and_also_further_amplified_the_cGAMP-mediated_antiviral_immune_response_/25292179

المؤلفون: Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Evolutionary Biology, Ecology, Immunology, Science Policy, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, protective innate immunity, play critical roles, innate immune response, antiviral immune strategy, antiviral immune responses, inhibit viral propagation, microtubule disruption synergizes, downstream signaling cascades, spectrum antiviral activity, div >< p, sting agonist cgamp, antiviral cytokines, viral infections, spectrum activities, sting signaling, signaling induces, microtubule network, microtubule destabilizer, vivo <, vitro <

Relation: https://figshare.com/articles/figure/A_graphic_model_for_MMAE_enhanced_cGAMP-mediated_antiviral_immunity_/25292185

الاتاحة: https://doi.org/10.1371/journal.ppat.1012048.g008
https://figshare.com/articles/figure/A_graphic_model_for_MMAE_enhanced_cGAMP-mediated_antiviral_immunity_/25292185

المؤلفون: Mollen, Erik W. J., Ient, Jonathan, Tjan-Heijnen, Vivianne C. G., Boersma, Liesbeth J., Miele, Lucio, Smidt, Marjolein L., Vooijs, Marc A. G. G.

المصدر: Mollen , E W J , Ient , J , Tjan-Heijnen , V C G , Boersma , L J , Miele , L , Smidt , M L & Vooijs , M A G G 2018 , ' Moving Breast Cancer Therapy up a Notch ' , Frontiers in Oncology , vol. 8 , 518 . https://doi.org/10.3389/fonc.2018.00518

مصطلحات موضوعية: breast cancer, Notch, personalized precision treatment, treatment resistance, resensitisation, GAMMA-SECRETASE INHIBITORS, MAMMARY STEM-CELLS, ESTROGEN-RECEPTOR-ALPHA, COMPREHENSIVE MOLECULAR PORTRAITS, EPITHELIAL-MESENCHYMAL TRANSITION, ACUTE LYMPHOBLASTIC-LEUKEMIA, SIGNALING INDUCES APOPTOSIS, ADVANCED SOLID TUMORS, REGULATORY T-CELLS, CARCINOMA IN-SITU

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/939b29ef-0be1-43ec-a4f2-90487220a1dc
https://doi.org/10.3389/fonc.2018.00518

المؤلفون: Yu-Fen Lu (171691), Da-Wei Liu (215185), I-Chen Li (171694), Jamie Lin (4903615), Chien-Ming Wang (11883858), Kuo-Chang Chu (11883861), Hsiao-Hui Kuo (11883864), Che-Yi Lin (218292), Ling-Huei Yih (11883867), Yun-Jin Jiang (43148), Sheng-Ping L. Hwang (9931949)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, div >< p, mediated lateral inhibition, >< sup ><, >- positive (<, epidermal mucous cells, notch signaling induces, >- overexpressing embryos, mucous cells, zebrafish embryos, mediated activation, >, notch signaling, living cells, 3 signaling, >- overexpressing, teleosts live, teleost epidermis, secretase inhibitors, secret mucus, results indicate, remains unclear, reduced numbers

Relation: https://figshare.com/articles/dataset/Data_underlying_S2Ac_S2Af_S2Be_S2Cd_S2Ch_S3Ac_S3Af_S3Bf_S3Cc_S3Dc_S3Df_S4Ac_S4B_S4Cc_S4Cf_S4Dc_S4Dg_S4Ed_S4Ee_S4Ei_S4Ej_S5Ad_S5Bd_S5Dc_S5Df_S5Dk_S5Dl_S5Do_and_S5Dr_Figs_/17700648

الاتاحة: https://doi.org/10.1371/journal.pgen.1009969.s007