المؤلفون: Anthony J. Roecker (2283145), Mark E. Layton (1443547), Joseph E. Pero (1443532), Michael J. Kelly (1443562), Thomas J. Greshock (2178438), Richard L. Kraus (2245585), Yuxing Li (263516), Rebecca Klein (310566), Michelle Clements (3448511), Christopher Daley (1779979), Aneta Jovanovska (10906887), Jeanine E. Ballard (2413057), Deping Wang (1992346), Fuqiang Zhao (494277), Andrew P. J. Brunskill (8727768), Xuanjia Peng (8063972), Xiu Wang (591762), Haiyan Sun (201818), Andrea K. Houghton (5340860), Christopher S. Burgey (2397964)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Biotechnology, Sociology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target modulation, compound 19, Lead optimization efforts, side effects, Selectivity Profile, Na v 1.7 electrophysiology protocols, novel multiparameter optimization, Na v 1.6, Na v 1.5, novel series, IVIVC, arylsulfonamide Na v 1.7 inhibitors, pain afflictions, vivo correlations, side effects preclinically, MPO Methods, target selectivity profile, voltage-gated sodium channel Na v 1.7

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Arylsulfonamide_Na_sub_v_sub_1_7_Inhibitors_IVIVC_MPO_Methods_and_Optimization_of_Selectivity_Profile/14714148

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00218.s002

المؤلفون: Anthony J. Roecker (2283145), Mark E. Layton (1443547), Joseph E. Pero (1443532), Michael J. Kelly (1443562), Thomas J. Greshock (2178438), Richard L. Kraus (2245585), Yuxing Li (263516), Rebecca Klein (310566), Michelle Clements (3448511), Christopher Daley (1779979), Aneta Jovanovska (10906887), Jeanine E. Ballard (2413057), Deping Wang (1992346), Fuqiang Zhao (494277), Andrew P. J. Brunskill (8727768), Xuanjia Peng (8063972), Xiu Wang (591762), Haiyan Sun (201818), Andrea K. Houghton (5340860), Christopher S. Burgey (2397964)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Molecular Biology, Pharmacology, Biotechnology, Sociology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target modulation, compound 19, Lead optimization efforts, side effects, Selectivity Profile, Na v 1.7 electrophysiology protocols, novel multiparameter optimization, Na v 1.6, Na v 1.5, novel series, IVIVC, arylsulfonamide Na v 1.7 inhibitors, pain afflictions, vivo correlations, side effects preclinically, MPO Methods, target selectivity profile, voltage-gated sodium channel Na v 1.7

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Arylsulfonamide_Na_sub_v_sub_1_7_Inhibitors_IVIVC_MPO_Methods_and_Optimization_of_Selectivity_Profile/14714145

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00218.s001