المؤلفون: Rodney A. Fernandes, Dashrath Jangid, Dnyaneshwar A. Gorve

مصطلحات موضوعية: Microbiology, Immunology, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, unanticipated bicyclic etherification, simple acid hydrolysis, asymmetric total syntheses, luche reduction conditions, diospongin b based, luche reduction, trans <, several analogues, practical applicability, h <, >- pyran, >- disubstituted, 6 -<

Relation: https://figshare.com/articles/journal_contribution/Unanticipated_Bicyclic_Etherification_in_Luche_Reduction_Asymmetric_Total_Syntheses_of_Diospongins_A_and_B_and_Tetraketide/24962374

الاتاحة: https://doi.org/10.1021/acs.orglett.3c03313.s001
https://figshare.com/articles/journal_contribution/Unanticipated_Bicyclic_Etherification_in_Luche_Reduction_Asymmetric_Total_Syntheses_of_Diospongins_A_and_B_and_Tetraketide/24962374

المؤلفون: Julia Beveridge (6693530), Eric Tran (234607), Girdhar Singh Deora (1676818), Fei Huang (9205), Yuzhi Wang (690944), Kieran Stockton (14375508), Ignacio Cotillo (685738), Maria Santos Martinez Martinez (14375511), Silvia Gonzalez (1322532), Pablo Castañeda (1662799), Julian Sherman (7372811), Ana Rodriguez (266842), Albane Kessler (2148916), Jonathan B. Baell (115410)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, promising new chemotype, observed excellent activity, novel diarylthioether compounds, diarylthioether compounds represent, cell phenotypic screen, chagas disease herein, chagas disease, vivo <, vitro <, several analogues, parasite responsible, mice infected, investigations led, hit optimization, hit compound, efficacy studies, chemical class

Relation: https://figshare.com/articles/journal_contribution/Novel_Diarylthioether_Compounds_as_Agents_for_the_Treatment_of_Chagas_Disease/21861573

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01725.s001

المؤلفون: Gaurav Sheth (14253980), Shailesh R. Shah (9235026), Prabal Sengupta (14253983), Tushar Jarag (14253986), Sabbirhusen Chimanwala (14253989), Kalapatapu V. V. M. Sairam (14253992), Vaibhav Jain (184214), Rashmi Talwar (5231093), Avinash Dhanave (14253995), Mehul Raviya (14253998), Soumya Menon (14254001), Shivangi Trivedi (14254004), Trinadha Rao Chitturi (14254007)

مصطلحات موضوعية: Biochemistry, Microbiology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pancreatic ductal adenocarcinoma, molecular docking studies, hence therapeutic targeting, cell viability assay, arrest tumor growth, >< sup ><, ><, selective me3 inhibitor, >/ me2 <, 50 , 16b , reported me1 inhibitor, >, viz <, smad4 <, me2 <, several analogues, ol amides, me3 takes

Relation: https://figshare.com/articles/journal_contribution/In_the_Quest_for_Potent_and_Selective_Malic_Enzyme_3_Inhibitors_for_the_Treatment_of_Pancreatic_Ductal_Adenocarcinoma/21720131

الاتاحة: https://doi.org/10.1021/acsmedchemlett.2c00369.s001

المؤلفون: Sameer Urgaonkar (1266348), Kamil Nosol (11857962), Ahmed M. Said (11857965), Nader N. Nasief (1828309), Yahao Bu (2973327), Kaspar P. Locher (1975069), Johnson Y. N. Lau (10319473), Michael P. Smolinski (10319467)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Mental Health, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, remained poorly absorbed, structure guided us, improve oral bioavailability, minimally absorbed p, >, dual p, 3a , vivo <, oral absorption, em structure, dual potency, dual inhibitors, human p, starting point, several analogues, prudently decorate, promising approach, pan inhibitions, em analysis, common substrates

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Characterization_of_Potent_Dual_P_Glycoprotein_and_CYP3A4_Inhibitors_Design_Synthesis_Cryo-EM_Analysis_and_Biological_Evaluations/17297457

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01272.s001

المؤلفون: Dickson Mambwe (6179453), Malkeet Kumar (3104340), Richard Ferger (10263608), Dale Taylor (1463830), Mathew Njoroge (1463821), Dina Coertzen (2587168), Janette Reader (1484494), Mariëtte van der Watt (6116213), Lyn-Marie Birkholtz (1484512), Kelly Chibale (503778)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Physiology, Pharmacology, Sociology, Developmental Biology, Chemical Sciences not elsewhere classified, amide compound 46, Chinese hamster ovary, LG, AST, Plasmodium falciparum, drug repositioning, 46 analogues, Several analogues, Pf NF 54 IC 50, late-stage gametocytes, antiplasmodium activity, compounds 21, IV, 100 μ M, SI, asexual blood stage parasites

Relation: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_Studies_Reveal_New_Astemizole_Analogues_Active_against_Plasmodium_falciparum_In_Vitro/15094087

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00328.s001

المؤلفون: Haoting Li (11668435), Anne E. Mattingly (9247975), Leigh A. Jania (6597362), Richard Smith (45265), Roberta J. Melander (1751032), Robert K. Ernst (127237), Beverley H. Koller (11668438), Christian Melander (1751038)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, resistant bacterial infections, identified several analogues, β inhibitor imd, 0354 analogues incorporating, several gram, recently disclosed, negative strains, negative bacteria, known ikk, global threat, generation library, benzimidazole moiety, benzimidazole isosteres, amide isostere

Relation: https://figshare.com/articles/journal_contribution/Benzimidazole_Isosteres_of_Salicylanilides_Are_Highly_Active_Colistin_Adjuvants/16965364

الاتاحة: https://doi.org/10.1021/acsinfecdis.1c00463.s001

المؤلفون: Julia Beveridge (6693530), Eric Tran (234607), Girdhar Singh Deora (1676818), Fei Huang (9205), Yuzhi Wang (690944), Kieran Stockton (14375508), Ignacio Cotillo (685738), Maria Santos Martinez Martinez (14375511), Silvia Gonzalez (1322532), Pablo Castañeda (1662799), Julian Sherman (7372811), Ana Rodriguez (266842), Albane Kessler (2148916), Jonathan B. Baell (115410)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, promising new chemotype, observed excellent activity, novel diarylthioether compounds, diarylthioether compounds represent, cell phenotypic screen, chagas disease herein, chagas disease, vivo <, vitro <, several analogues, parasite responsible, mice infected, investigations led, hit optimization, hit compound, efficacy studies, chemical class

Relation: https://figshare.com/articles/dataset/Novel_Diarylthioether_Compounds_as_Agents_for_the_Treatment_of_Chagas_Disease/21861576

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01725.s002

المؤلفون: Sameer Urgaonkar (1266348), Kamil Nosol (11857962), Ahmed M. Said (11857965), Nader N. Nasief (1828309), Yahao Bu (2973327), Kaspar P. Locher (1975069), Johnson Y. N. Lau (10319473), Michael P. Smolinski (10319467)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Mental Health, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, remained poorly absorbed, structure guided us, improve oral bioavailability, minimally absorbed p, >, dual p, 3a , vivo <, oral absorption, em structure, dual potency, dual inhibitors, human p, starting point, several analogues, prudently decorate, promising approach, pan inhibitions, em analysis, common substrates

Relation: https://figshare.com/articles/dataset/Discovery_and_Characterization_of_Potent_Dual_P_Glycoprotein_and_CYP3A4_Inhibitors_Design_Synthesis_Cryo-EM_Analysis_and_Biological_Evaluations/17297460

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01272.s002