المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/journal_contribution/Times_of_birth_for_Caesarean_section_deliveries_associated_with_biopsies_from_RNA-seq_second_cohorts_/17050428

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s007

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_shared_and_unique_down-regulated_FC_1_5_DEGs_relative_to_TNL_for_all_labour_classifications_of_interest_/17050425

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s006

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_shared_and_unique_up-regulated_FC_1_5_DEGs_relative_to_TNL_for_all_labour_classifications_of_interest_/17050422

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s005

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_up-_and_down-regulated_FC_1_5_DEGs_for_TEaL_vs_TNL_and_TEsL_vs_TNL_comparisons_/17050410

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s001

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_up-_and_down-regulated_FC_1_5_DEGs_for_TL-ROM_vs_TNL_and_TL_ROM_vs_TNL_comparisons_/17050413

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s002

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_enriched_GO_terms_for_up-_and_down-regulated_FC_1_5_DEGs_at_TL-ROM_vs_TNL_and_TL_ROM_vs_TNL_comparisons_/17050419

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s004

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/figure/PCA_for_RNA-seq_of_myometrium_biopsies_from_term_pregnant_women_at_different_stages_of_labour_/17050431

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.g001

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Patient_demographics_for_myometrium_placenta_biopsies_of_the_RNA-seq_cohort_Grouped_by_status_of_fetal_membrane_rupture_ROM_/17050455

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t003

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Lists_of_enriched_GO_terms_for_up-_and_down-regulated_FC_1_5_DEGs_at_TEaL_vs_TNL_and_TEsL_vs_TNL_comparisons_/17050416

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.s003

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/figure/Relative_mRNA_abundance_determined_by_qPCR_for_transcriptomics-identified_myometrial_DEGs_common_to_TEaL_in_second_cohort_tissues_/17050443

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.g004

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/figure/Relative_mRNA_abundance_determined_by_qPCR_for_transcriptomics-identified_myometrial_DEGs_common_to_four_labour_classifications_in_RNA-seq_cohort_tissues_/17050437

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.g003

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/figure/Grouping_human_myometrium_FC_1_5_DEGs_according_to_cervical_dilatation_or_ROM_status_at_labour_/17050434

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.g002

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Patient_demographics_for_myometrium_placenta_biopsies_of_the_RNA-seq_cohort_Grouped_by_phases_of_labour_as_determined_by_cervical_dilatation_/17050452

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t002

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Patient_demographics_for_myometrium_placenta_choriodecidua_biopsies_used_as_independent_second_cohort_for_qPCR_validation_of_RNA-seq_findings_/17050458

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t004

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Top_five_enriched_gene_ontology_biological_processes_terms_for_human_myometrium_in_different_labour_states_/17050464

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t006

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Primers_for_qPCR_/17050449

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t001

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/Number_of_differentially_expressed_genes_in_human_myometrium_identified_by_RNA-seq_for_different_labour_states_/17050461

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t005

المؤلفون: Pei F. Lai (6741833), Kaiyu Lei (117773), Xiaoyu Zhan (7548134), Gavin Sooranna (11731071), Jonathan K. H. Li (11731074), Ektoras X. Georgiou (11731077), Ananya Das (1838386), Natasha Singh (9706948), Qiye Li (3282765), Zachary Stanfield (6531962), Guojie Zhang (146963), Rachel M. Tribe (9465126), Sam Mesiano (10570), Mark R. Johnson (117795)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Physiology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, high throughput sequencing, fetal membrane rupture, enriched signalling networks, assessed whether differences, alternative omics approaches, lower degs frequency, div >< p, seq limitations associated, rom negative myometrium, seq data, human myometrium, ≤ 3, truly contributes, transcriptomic changes, transcriptome changes, tissue heterogeneity, singular state, rom ), present study, potentially altered, per3 <, labouring state, gene transcription, future data

Relation: https://figshare.com/articles/dataset/RNA-seq_summary_for_differentially_expressed_genes_common_to_four_labour_classifications_in_human_myometrium_/17050467

الاتاحة: https://doi.org/10.1371/journal.pone.0260119.t007