المؤلفون: Mark E. Layton (1443547), Jeffrey C. Kern (2399026), Timothy J. Hartingh (1503232), William D. Shipe (1514749), Izzat Raheem (14370322), Monika Kandebo (10947802), Robert P. Hayes (9220508), Sarah Huszar (14370325), Donnie Eddins (14370328), Bennett Ma (14370331), Joy Fuerst (5175641), Gordon K. Wollenberg (14370334), Jing Li (10611), Jeff Fritzen (7491188), Georgia B. McGaughey (1270989), Jason M. Uslaner (1514734), Sean M. Smith (1514728), Paul J. Coleman (1834798), Christopher D. Cox (1514737)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Mental Health, Hematology, Chemical Sciences not elsewhere classified, rational design led, potentially novel means, normalize dysfunctional activity, selective pde10a inhibitor, pde10a inhibition represents, developing pde10a inhibitors, dysfunctional striatal activity, isomeric pyrimidine series, 18 , striatal signaling, schizophrenia pde10a, target activities, physicochemical properties, liabilities seen, important regulator, highly potent, fragment hit, early optimization, earlier compounds

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_MK-8189_a_Highly_Potent_and_Selective_PDE10A_Inhibitor_for_the_Treatment_of_Schizophrenia/21856102

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01521.s001

المؤلفون: Mark E. Layton (1443547), Jeffrey C. Kern (2399026), Timothy J. Hartingh (1503232), William D. Shipe (1514749), Izzat Raheem (14370322), Monika Kandebo (10947802), Robert P. Hayes (9220508), Sarah Huszar (14370325), Donnie Eddins (14370328), Bennett Ma (14370331), Joy Fuerst (5175641), Gordon K. Wollenberg (14370334), Jing Li (10611), Jeff Fritzen (7491188), Georgia B. McGaughey (1270989), Jason M. Uslaner (1514734), Sean M. Smith (1514728), Paul J. Coleman (1834798), Christopher D. Cox (1514737)

مصطلحات موضوعية: Biochemistry, Cell Biology, Neuroscience, Pharmacology, Biotechnology, Developmental Biology, Mental Health, Hematology, Chemical Sciences not elsewhere classified, rational design led, potentially novel means, normalize dysfunctional activity, selective pde10a inhibitor, pde10a inhibition represents, developing pde10a inhibitors, dysfunctional striatal activity, isomeric pyrimidine series, 18 , striatal signaling, schizophrenia pde10a, target activities, physicochemical properties, liabilities seen, important regulator, highly potent, fragment hit, early optimization, earlier compounds

Relation: https://figshare.com/articles/dataset/Discovery_of_MK-8189_a_Highly_Potent_and_Selective_PDE10A_Inhibitor_for_the_Treatment_of_Schizophrenia/21856105

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01521.s002