يعرض 1 - 20 نتائج من 25 نتيجة بحث عن '"selection impacts LD"', وقت الاستعلام: 0.40s تنقيح النتائج
  1. 1
    Academic Journal
    Predicted effect of negative selection on linkage disequilibrium decay.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/journal_contribution/Predicted_effect_of_negative_selection_on_linkage_disequilibrium_decay_/15069395

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s018

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  2. 2
    Academic Journal
    Effect of negative selection and complex demography on LD.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/journal_contribution/Effect_of_negative_selection_and_complex_demography_on_LD_/15069398

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s019

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  3. 3
    Image
    Demographic models for simulations.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Demographic_models_for_simulations_/15069344

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s001

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  4. 4
    Image
    Decay of mean r 2 for different recombination and dominance parameters.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Decay_of_mean_i_r_i_sup_2_sup_for_different_recombination_and_dominance_parameters_/15069347

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s002

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  5. 5
    Image
    Doubletons in a sample of 50 individuals are more deleterious than higher frequency variants.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Doubletons_in_a_sample_of_50_individuals_are_more_deleterious_than_higher_frequency_variants_/15069350

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s003

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  6. 6
    Image
    Pictorial representation of variants in coupling and repulsion.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Pictorial_representation_of_variants_in_coupling_and_repulsion_/15069353

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s004

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  7. 7
    Image
    Mean r 2 for simulated nonsynonymous doubletons within 10kb of each other across different recombination and dominance parameters.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Mean_i_r_i_sup_2_sup_for_simulated_nonsynonymous_doubletons_within_10kb_of_each_other_across_different_recombination_and_dominance_parameters_/15069356

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s005

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  8. 8
    Image
    Decay of D from simulated NS and S doubletons.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Decay_of_i_D_i_from_simulated_NS_and_S_doubletons_/15069359

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s006

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  9. 9
    Image
    Decay of D for simulated NS and S doubletons in scenarios with migration.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Decay_of_i_D_i_for_simulated_NS_and_S_doubletons_in_scenarios_with_migration_/15069362

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s007

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  10. 10
    Image
    Mean selection coefficient of deleterious doubletons in our simulated samples and their population of origin.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Mean_selection_coefficient_of_deleterious_doubletons_in_our_simulated_samples_and_their_population_of_origin_/15069365

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s008

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  11. 11
    Image
    Pictorial representation of n AB and H R (1) .

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Pictorial_representation_of_n_sub_AB_sub_and_HR_1_/15069371

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s010

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  12. 12
    Image
    Spearman’s rank correlation coefficient (⍴) between H R (j) and D ’.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Spearman_s_rank_correlation_coefficient_between_HR_j_and_i_D_i_/15069374

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s011

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  13. 13
    Image
    Simulations under demographic Model 2 predict NS pairs of doubletons are more often in complete repulsion than S pairs of doubletons.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Simulations_under_demographic_Model_2_predict_NS_pairs_of_doubletons_are_more_often_in_complete_repulsion_than_S_pairs_of_doubletons_/15069368

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s009

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  14. 14
    Image
    Flow chart of the matched-pairs permutation test.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Flow_chart_of_the_matched-pairs_permutation_test_/15069377

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s012

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  15. 15
    Image
    Matching rules for features and their distribution across NS variants and S variants in empirical data.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Matching_rules_for_features_and_their_distribution_across_NS_variants_and_S_variants_in_empirical_data_/15069380

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s013

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  16. 16
    Image
    Matched-pairs permutation test on various LD summary statistics in simulations without negative selection.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Matched-pairs_permutation_test_on_various_LD_summary_statistics_in_simulations_without_negative_selection_/15069383

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s014

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  17. 17
    Image
    Mean normalized difference in D across genetic distance quantiles for multiple 1KGP populations.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Mean_normalized_difference_in_i_D_i_across_genetic_distance_quantiles_for_multiple_1KGP_populations_/15069386

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s015

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  18. 18
    Image
    Summary statistics of D ’ across allele counts for neutral (S) and deleterious (NS) variants.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Summary_statistics_of_i_D_i_across_allele_counts_for_neutral_S_and_deleterious_NS_variants_/15069389

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s016

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  19. 19
    Image
    Summary of empirical data used in the figures.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Summary_of_empirical_data_used_in_the_figures_/15069392

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.s017

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  20. 20
    Image
    Mean D’ for simulated NS doubletons within 10kb from each other across different recombination and dominance parameters.

    المؤلفون: Jesse A. Garcia (11198585), Kirk E. Lohmueller (8026796)

    مصطلحات موضوعية: Genetics, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, nonsynonymous SNPs, selection impacts LD, recessive mutations, statistic H R, allele, genome sequences, background selection, shape genome-wide patterns, unphased genotypes, 10 kb, influences genome-wide patterns, haplotype, Negative linkage disequilibrium, Hill-Robertson interference, dominance coefficients, selection coefficients, additive effects, forward-in-time simulations, variant, genome Evolutionary forces, 1000 Genomes Project, LD decay, linkage disequilibrium

    Relation: https://figshare.com/articles/figure/Mean_i_D_i_for_simulated_NS_doubletons_within_10kb_from_each_other_across_different_recombination_and_dominance_parameters_/15069401

    الاتاحة: https://doi.org/10.1371/journal.pgen.1009676.g001

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